General Papers ARKIVOC 2008 (xi) 131-141
170.7. Mass (m/z): 362. Anal. (%) for C20H18N4O3, Calcd. C, 66.29; H, 5.01; N, 15.46; O, 13.25; Found: C, 66.29; H, 5.01; N, 15.46; O, 13.25. 6-(2-Furyl)-4[(4)-carboxyphenylazomethyl]-2-hydroxyl-1,6-dihydropyrimidine (3j). Yield 64%, mp. 236-238 ºC, IR (KBr) 1569 (C=C ring skeleton Ar. moiety), 1418 (C=C ring skeleton pyrimidine moiety), 1489 (N=N), 1701 (C=O of acid), 3210 (N-H), 3404 (OH); 1H–NMR (DMSO-d6): d 2.39 (s, 2H, CH2), 4.49 (d, 1H, NH-CH), 4.84 (s, 1H, OH), 5.14 (s, 1H, NH), 5.89 (d, 1H, CH), 6.32-8.29 (m, 7H, Ar-H, furyl), 12.30 (s, 1H, OH); 13C-NMR (CDCl3): d 48.2, 62.3, 107.3, 111.3, 118.6, 122.7, 127.6, 131.2, 139.8, 142.0, 153.6, 157.4, 163.7, 171.6. Mass (m/z): 326. Anal. (%) for C16H14N4O4, Calcd. C, 58.89; H, 4.32; N, 17.17; O, 19.61; Found: C, 58.89; H, 4.32; N, 17.17; O, 19.61. Acknowledgements
The authors wish to thank the Professor and Head, Department of Chemistry Saurashtra University, Rajkot for research facilities. Authors are thankful to CDRI Lucknow for spectral and analytical data. We thank the Tuberculosis Antimicrobial Acquisition and Coordinating Faculty (TAACF), www.taacf.org for the in vitro antimycobacterial screening.
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