Special Issue Reviews and Accounts ARKIVOC 2007 (ii) 54-120
Treatment of 443 with DMSO, NaCl and water (140oC, 4 h) led to 444 (quantitatively). A rational mechanism is proposed.233
CO2Me
MeO2C CO2Me O OH
O O CO2Me
HO
MeO2C
CO2Me CO2Me
MeO2C
443 444
3. Conclusions Dealkoxycarbonylations of a wide variety of substrates have been accomplished using NaCN, NaCl or LiCl and water in dipolar aprotic solvents such as DMSO and DMF. This procedure will continue to be useful in the dealkoxycarbonylations of activated ester functionalities.
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