(a) To harass, rout, defeat, or annihilate (an adversary); harass (a person or people); (b) to frustrate (sb.); refl. defeat (oneself); (c) to harm or destroy (sth.); refute (a doctrine).

Theol. (a) To condemn or curse (sb.); also, put a curse on (sb. or sth.); (b) to lead (sb.) into sin or to perdition.

(a) To perplex or embarrass (sb.); bewilder or confuse (the mind, thought); (b) to encumber or beset (sb., the mind); also, overcome, prostrate; (c) to put (sb.) to shame; disgrace.

Misc. uses: (a) to mix (things); (b) to confuse (a situation); (c) to spoil (sth.); (d) to end.