ï~~JN rn ool the men had always enjoyed very good health, some of them havi never been ill, to their knowledge, in their lives. As to contact wit influenza patients since the early autumn, 18 men (42 per cent) ha not been exposed; 12 men (28 per cent) had experienced the casu contact of the ordinary walks of life, while 11 men (26 per cent) he had close contact with patients ill with influenza. Volunteer No.2 gave a history of an attack of influenza while at Deer Islaidi September, 1918. Another, No. 40, probably had an attack wh at Portsmouth, N. H., in October, 1918. The names, numbers, and ages of the men, with their historys regards exposure to influenza and the result of examination for su ceptibility to diphtheria by the Schick test, are given in Table I. During the first week of their sojourn on the island, the men we: quartered in large barracks, ate at the same mess and were allow to congregate at will. They entered into out-of-doors sports a did light chores about the station. For five days before the fir experiment was inaugurated their temperatures were taken at 8. in the morning and at 6.30 in the evening. During this period of observation, from February 5, 1919,1 February 10, 1919, 12 men reported at sick call with varying degre of tonsillitis. Of these, three were admitted to the hospital, co plaining of sore throat, headache and. malaise. One, No. 44, had fever (38.60 C.) for the first evening only; the temperature of ti others did not reach 37.8Â~ C., and all were discharged in 72 hours less, having completely recovered from their complaints. Another man, F. K. E., No. 18, presented a more perplexi syndrome. He became ill the day of his arrival on the islan having felt perfectly well before this. This volunteer, and No. 4 who had badly involved tonsils and fever of one afternoon's durati were not accepted as fit subjects for experimentation due to physic disabilities. The clinical data of this case are herewith given: F. K. E. (age 24, No. 18).-Not used in experiment. Diagnosis.-Daily intermittent fever of unknown origin a paroxysmal tachycardia. The patient said that he had always been healthy, with no serio illness except an attack of pleurisy and arthritis in February, 191 He stated that he had had no exposure to influenza. He came Gallups Island February 4, 1919, feeling well. On the afternoon of February 5, 1919, the day after his arriv the patient's temperature was 38.20 C. but he had no complai He turned into his bunk early and the following morning his te perature was 36.9Â~ C. The same evening, the temperature w 38.3 C., with the patient still feeling well, but he was admitted the hospital for observation. He had been constipated for the th previous days. The next morning (Feb. 7) the patient's temperature was 370 C. and he complained of some headache and vague pains in the epigastrium and chest. The headache was frontal, temporal, and occipital in distribution and was worse when the temperature was highest. There was but little lassitude, weakness, or depression at any time, and all subjective symptoms disappeared each morning with the subsidence of the fever. No vertigo, photophobia, cough, dyspnea, hemoptysis, vomiting, diarrhea, jaundice, nor any symptoms pointing to genito-urinary involvement developed. The patient never complained of sore throat. Physical examination on admission was negative. During his stay in the hospital, the patient's temperature inter'mitted daily, varying from 36.2Â~ in the morning to 39.2Â~ C. in the evening and gradually coming down on the seventh day to normal, but rising to 37.6Â~ on the ninth day and to 380 on the twelfth. The pulse (except as noted below) ranged from 72 to 100; the respirations from 18 to 24. The leucocyte count of February 9, was 15,800, dropping to 7,800 four days later. Urine analyses were negative. On February 13, 1919, a careful examination of the patient was made by Drs. Leake, Lake; and Richey. It was decided that, in view of the leucocytosis, the intermitting fever, continuing for a week or more without severe symptoms, and the absence of prostration, back pains, photophobia, flushing, or cough, the case could not be diagnosed as influenza, though the possibility of an atypical attack could not be entirely ruled out. On the evening of February 16,1919, after the temperature had been normal for five days, while the patient was lying quietly in bed, he became conscious of palpitation. On examination at this time it was found that the apex beat was 220 and quite regular. There were no signs of cardiac decompensation. In the course of 20 or 30 minutes, immediately after the application of an ice bag to the precordium, the heart rate returned to 72 as rapidly as it had increased. He said that he has had at least three such attacks, the last occurring four months ago. In the absence of gross irregularity and a pulse deficit, this attack was considered one of paroxysmal tachycardia. The patient was discharged from the hospital on February 17, 1919, having quite recovered. His nasopharyngeal flora at the time was pneumococcus, staphylococcus, a gram negative diplococcus and B. influenzae. In view of the bare possibility that this might have been an anomalous case of influenza and on account of the presence of a cardiac arrhythmia, the patient was considered as not a fit subject for experimentation.