Pharmaceutice rationalis: or, The operations of medicines in humane bodies. The second part. With copper plates describing the several parts treated of in this volume. By Tho. Willis, M.D. and Sedley Professor in the University of Oxford.

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Title
Pharmaceutice rationalis: or, The operations of medicines in humane bodies. The second part. With copper plates describing the several parts treated of in this volume. By Tho. Willis, M.D. and Sedley Professor in the University of Oxford.
Author
Willis, Thomas, 1621-1675.
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London :: printed for Thomas Dring, Charles Harper, and John Leigh, booksellers in Fleet-street,
1679.
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Materia medica -- Early works to 1800.
Pharmacology -- Early works to 1800.
Medicine -- Early works to 1800.
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"Pharmaceutice rationalis: or, The operations of medicines in humane bodies. The second part. With copper plates describing the several parts treated of in this volume. By Tho. Willis, M.D. and Sedley Professor in the University of Oxford." In the digital collection Early English Books Online 2. https://name.umdl.umich.edu/A71263.0001.001. University of Michigan Library Digital Collections. Accessed May 23, 2024.

Pages

CHAP. I. Of the Jaundies and the remedies thereof, and the manner and reason of their operations.

HItherto we have largely enough unfolded the Pathologie and curatory me∣thod of the Thorax; now it follows next to finish our task in like manner a∣bout the lower Belly. But we have in our former tract for the most part described already the medicines belonging to this region, and the manner and rea∣sons of their working, together with the Anatomy of the Stomach and Intestines: we have treated of remedies stomachical, dysenterical, and others belonging to the in∣testines, as also diureticks together with the reasons of them: Moreover we have sus∣sicently elsewhere handled the aetioligie of Hypochondriack, and Hysterical reme∣dies. What therefore remains, of Hepatical distempers as well proper, as of those vulgarly ascrib'd thereunto, and of their remedies we will discourse in this Section; notwithstanding in each of these, we will bestow more labour, about the curatory, than pathological part.

The chief diseases by which the Liver and the appendix thereof, are wont to be incumbred, are the Jaundies, and a Tumour, and under this latter many other affects, viz. obstruction, inflammation, induration, and schirrus are numbred; to all which are vulgarly appointed remedies commonly called Hepaticks, and which make up a great part of the Dispensatory.

The Jaundies is either a disease by it self, primarily beginning, which is here pro∣perly treated of: or it is an effect or product of another disease; as when it arises upon an intermitting Feaver, which oftentimes it puts an end to, of which also we will presently treat by the by.

An Icterical distemper by the common consent of most is judged to arise in as much as the yellow choler, not at all, or not enough received, from the ends of vena porta, into the passages of the cholerick pore, overflows into the mass of blood and pollutes it with its greenness, whereby also the very skin is discolour'd.

That obstruction is wont to happen after many manners and in various places. For sometimes it happens near the extream ends of either kind of vessels, viz. the end of the vena porta, and the porus bilarius; the interspaces whereof happen frequently to be compressed, and stopt by reason of the Parenchyma of the Liver being tume∣fied, or otherwise vitiated; wherefore the humour of the gall not being transferred out of the separating vessels of the porta into the other receiving vessels, turns back upon the blood. Secondly, the passage of the humour of the gall is sometimes intercept∣ed in the middle passages of the cholerick pore; for that the cavities of these are filled either with a viscous, or sandy, and sometimes with a stony matter; as is plainly discerned in the Livers of beasts in the winter senson, while they are fed with hay and straw. Thirdly, it is also manifest by Anatomical observation, some∣times an obstruction in the very bladder or the gall, or in the cystic passage is the cause of the Jaundies; for if at any time, it being filled with stones, receive not the choler, or being here shut up, or grown together, it restrains the descent of the choler towards the guts, that humour although well separated from the blood, is constrained to flow black into the mass thereof, and so propagates the Jundies.

Against this most received opinion, by which it is judged, that the cause of the Jaundies for the most part consists on this side the vesica fellis or about it towards the Liver: the most Renowned Sylvius altogether places it without this, viz. in the

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Cystic or common passage. For supposing the choler not to be separated from the blood, within the passages of the Liver, but in the very bladder of the Gall to be pro∣pagated of a humour brought thither by the Arteries; He judged the greatest part, being carried upwards by the passage of the pori bilarii, to be poured into the blood for some notable uses, and also another part to descend beneath to the Intestines, also for necessary uses: wherefore if this latter sluce be shut, all the choler is carried upwards into the blood, and filling it too much with this humour, perverts it from its genuine temper, into an Icterical.

But truly lest the stopping of the passage of the bladder, or of the common passage, (neither of which easily happens, or from any light occasion) may seem less effica∣cious to excite any Jaundies; therefore, whether such an obstruction hath place, or no, the most Renowned man ingeniously supposes besides, The choler while it is generated in the bladder does undergo sometimes a notable change, by which it is moved, and is born about more plentifully and impetuously, towards the blood, with which yet it is less mingled than is was wont to be, but only confounded together with it, and so more easily departs from it and infects and tinges the solid parts with its colour.

But that the choler in the Jaundies may be rendred unfit a mix with the other humours, or to be nearly united; he determines it to be done, by a spirit too valatile, mixed plentifully with it, and so making it more spirituous and immiscible with others. He confirms this assertion by two instances, viz. in as much as the most spirituous poison from the biting of a Viper, and the too much use of the more generous drinks, viz. Wine and Strong-waters, causes sometimes the Jaundies. Moreover he endeavours to procure credit to this Hypothesis, for that this disease is wont to be cured, not only by medicines opening obstructioins, but by them which blunt the force of a ra∣ging volatile salt (of which sort are the decoction of Hemp-seeds, also Venice soape with many other things of the same sort.)

It belongs not to this place, neither is it to our purpose to descend to end this con∣tention, nor dare I now rashly determine it (since it hath tired so many Renowned Wits of the Moderns) whether really the choler be made in the bladder of the Gall, or whether it be only separated from the blood in the Liver, the great organ of separation; I confess this latter opinion best pleases me. And weighing these things seriously I am induced to think the cause of the Jaundies to consist chiefly in this, that the choler be∣ing sever'd in the Liver, is not, by reason of the ways being obstructed, at all, or not enough conveyed to the bladder of the Gall, but that it must of necessity regurgi∣tate into the mass of blood; notwithstanding in the mean while we deny not, but this affect may sometime arise (although more rarely) from the Cystic passage or common pipe being obstructed. But also we think the fault of the blood to preceed in part and perhaps sometimes wholly for the morbific cause; when to wit from its sulphurous and fixt Saline Particles above measure exalted, the choler is more plenti∣fully, or quicklier generated in the mass of blood, than can be separated or discharged forth by the ordinary ways; wherefore this, separating every where from the blood with the Serum, is affixed to the solid parts, and impresses its tincture upon them. And without doubt it is for this reason that some poisons, and chiefly the biting of Vipers, and the dayly use of more generous drinks, induces the Jaundies in bodies be∣fore sound, for whose cure sometime Phlebotomie, and medicines reducing the blood to a right temper, are wont to profit more than those opening obstructions. More∣over it seems for this reason, that a tertian intermiting Feaver so frequently termi∣nates in the Jaundies; for we may not suspect the passages of the Liver can be by any means obstucted, since in all fits, so great an agitation of the blood and humours, by cold, and heat, and such an-evacuation of them happens either by vomit or sweat: and truly even as feaverish fits are caused, inasmuch as the sulphurous part of the blood being too much advanced, in the first place perverts the nutritious juice into a morbific matter, and afterwards being inflam'd consumes and exterminates it; so when the fixt salt is at last exalted together with the sulphur in the blood, and for that cause meer choler is abundantly engendered, the feaversh enkindling of the blood ceases, by reason of the restrictive force of the fixt salt, and in place thereof the distemper of the Jaundies doth succeed. But as the blood being too much advanced to a sulphureo∣saline distemperature causes the Jaundies in any, though least predispos'd to it; so in others very much disposed thereto, having the ways of choler obstructed & the sulphur of the blood being too much depressed, it produces a freedome from that disease; for I have known many cachectick and phlegmatick persons, to have been free from the Jaun∣dies

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though they have suffered under obstructions and indurations of the Liver, as to most of its passages.

It is not worth our labour to make more ample disquisition about the aetiologie of this disease; as to what respects the cure, there will be three primary indications, all which (for what may be the chiefest of them, and first to be exhibited, for the most part is concealed) we shall prosecute together; wherefore the intentions of healing shall be, 1. That the obstructions of the passages or choler-bearing vessels be opened, if perhaps any shall be either in the porus bilarius, in the Cystic passage, or in any place about the Liver. 2. That the blood be reduced to its due temperament and mixture, lest it ingender choler above measure, or render it unapt to be voided. 3. That the strength may be sustain'd, and the symptomes chiefly hurting them may be with∣stood.

1. That we may satisfie the first indication, cathartic evacuations notably con∣duce, as well by vomit, as siege, whereby the choler's descending towards the inte∣stines may be furthered, and vessels obstructed, by the great snaking of them, freed from their obstruction. 2. Sharp, bitter, salt medicines and others indued with a cer∣tain briskness ought also to be given, which provoke the motion of choler gathered in the Liver, and stagnating; hither also ought to be referred, what by similitude of substance, and as it were signature, in as much as they are indued with a yellow juice, have the report to help against the Jaundies; notwithstanding many of these may fitly be numbred under the same classis of evacuators, as the former, because they move urine or sweats.

The second indication altogether requires alteratives, viz. medicines which may depress the exaltations, or ragings of the Sulphur and fixt salt, and in the mean time provoke the restitution of the volatile salt depressed; for these ends remedies endued with an acid or volatile salt, besides chalybeats do principally bring help; from hence spirit of salt, of vitriol, juice of Lemons, also spirit of Harts-horn, also dung of Sheep, and Geese, crocus Martis and diverse other preparations thereof, are fre∣quently used with success in the Jaundies.

The third indication vital suggests more and sundry intentions of cure, procuring the strength to be restored, and the removing the symptomes whereby it is prejudiced, all or the chief particularly to enumerate, and prescribe would be a vast and tedi∣ous work; wherefore we will annex only certain general rules about diet, and some cordials and anodynes appropriate in this condition.

The curatory indications being appointed after this manner, it next lies upon us to acommodate the most select medicines, viz. as well the simple as the compound, to these now proposed intentions of curing, and to unfold the manner and reason of the operating of remedies which are accounted of special note in this disease. There∣fore first we propound the forms of evacuating medicines appropriate in the Jaun∣dies.

1. Vomits.

Vomiting medicines are frequently wont to help in the recent Jaundies, while the tone and strength of the bowels are firm; in as much as they alleviate the stomach always oppressed in this disease with an unprofitable burden of viscous phlegm; and moreover do free their infarctions by irritating the vasa choledocha, and by much shaking all the passages of the Liver, and make easie the passage of the cholet by the former accustomed ways.

Take of the infusion of Crocus Metallorum half an ounce to six drams, Wine of Squils an ounce, Oxymel simple half an ounce, make a vomit to be taken with government.

Sometimes it is convenient to exhibite, the evening before, the following preparatory medicine for the easier vomiting.

Take of the powder of Asarum roots, faeculae Aronis of each a scruple, of Tartar vitrio∣lated half a scruple, of Oxymel of Squils an ounce, mix them.

Take of Sulphur of Antimony seven grains, Scammony sulphurated eight grains, cream of Tartar half a scruple, make a powder, give it in a spoonful of panada.

Take nine Asarabacca leaves, cut and bruised put them into three ounces of white wine, press out the liquor, let it be taken in the morning with regiment.

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Take of Gambugia prepared eight grains, Tartar vitriolated seven grains, make a powder.

2. Catharticks.

Purgers take place in this disease, be it recent or inveterate, viz. that as well a more plentifull store of Excrements may be now and then withdrawn from the first passages, as that the vasa choledocha may be excited to Excretions.

Take of Electuary of juice of Roses three drams, Rhubarb a dram, Salt of Wormwood, Cream of Tartar, of each half a Scruple, Syrup of Rhubarb, make a Bolus.

Take of the roots of sharp-pointed Dock prepared one ounce, the tops of Roman Worm∣wood, of Centaury the less, of each P. ij. Gentian and Turmerick roots an. two drams, yellow Saunders one dram, boyl them in a pinte and a half of Spring-water to a pinte, ad∣ding towards the end Senna six drams, the best Rhubarb three drams, Agarick a dram and half, Coriander-seeds two drams, White-wine two ounces, let them boyl close two hours, after strain it and clarifie it by settling; the Dose from four ounces to six, with one ounce of Syrup of Rhubarb, the water of Earth-worms three drams; make a potion to be repeated every or every other day, for three or four dayes.

In a weaker Constitution.

Take choice Rhubarb two drams, Agarick trochiscated, half a dram, Cinnamon half a scruple, Ginger half a scruple, make an infusion in White-wine and Cichory-water, of each three ounces, for three hours, in it strained dissolve one ounce of Syrup of Rhubarb, water of Earthworms two drams. Or Rhubarb from half a dram to a whole one, Salt of Worm∣wood a scruple, make a powder.

Take pil. Ruffi a scruple, Extr. Rudii half a scruple, make 4 Pills, take them in a morn∣ing with government, after 4 or 5 dayes repeat them.

In the third place follow Deoppilatives, which are also Diureticks, or Diaphoreticks, some whereof are accounted specifick, by reason of similitude of substance; Medicines of this sort, both promote the separation of choler from the blood, and urge the passage of it, being separated, through the passages and pores in the Liver open but little. Moreover, in the mean time, by dissolving the blood, they carry off the serosities and cholerick recrements thereof, sometimes by sweats and urine.

Take of Elixir Proprietatis one ounce, take 20 drops in the morning, and at Five in the afternoon, with a convenient vehicle: after the same manner are taken, Tincture of Antimony, or of Salt of Tartar, and the simple mixture in a greater Dose: for vehicles, Apo∣zemes, distilled Waters, and Juleps for this Intention of curing are convenient.

Take of the roots of Celandine the greater, stinging Nettles, Madder, of each one ounce, tops of Roman Wormwood, white Horehound, Agrimony, Germander, of each one hand∣full, Worm-seeds two drams, Shavings of Ivory and Harts-horn, of each two drams, yellow Sanders a dram and a half, Coriander-seeds two drams, boyl them in three pound of Spring∣water to two pound, adding of White-wine four ounces, strain it, and adde Syrup of Chi∣chory with Rhubarb two ounces, water of Earth-worms, an ounce and a half, make an Apozeme, the Dose four or six ounces twice in a day.

Take of white Horehound dryed, Centaury, of each one handful, Gentian and Turme∣rick-roots, of each three drams, Cinamon one dram, Saffron half a dram, being sliced put them into a Glass with two pound of White-wine or Rhenish-wine; make an infusion, the dose three ounces.

To this we will adde Gesners famous Antictericum.

Take of the roots of stinging Nettles a pound, Saffron one scruple, bruise them well, and draw off the tincture with White-wine, the dose three ounces 4 or 5 dayes.

Like to the former is that of Fr. Joel. Take the Roots of Celandine the greater, two handfuls, Juniper-berries a handfull, bruise them and pour on them a pound of Rhenish∣wine, and draw out the juice, the dose sour ounces twice a day.

The juice of white Horehound is mightily commended by Dioscorides, and the Syrup of the same by Forestus, for curing the yellow Jaundice.

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In lieu of an Elixir, and other chymical liquors, which to avoid nauseousness are to be taken in very small quantity; to others endued with a stronger Constitution, Electua∣ries, Powder and Pills may be administred with better success.

Take of Conserve of Roman Wormwood, of the yellow Rinds of Oranges and Limons, of each two ounces, Species Diacurcumae one dram and half, powder of Ivory, yellow Saun∣ders, of Lignum-Aloes, of each half a dram, Troches of Capers one dram, of Rhubarb half a dram, Salt of Wormwood two drams, with Syrup of Cichory with Rhubarb, make an Electuary, the dose the quantity of a Chesnut twice a day, drinking after it three ounces of the following Julep.

Take of the greater Celandine-water, Fumitory, Wormwood, Elder-flowers of each five ounces, Snail-water, water of Earth worms, compound, of each two ounces, Sugar half an ounce, mingle them and make a Julep. Or,

Take of the roots of stinging Nettles, Angelica, Gentian, of each four ounces, the greater Celandine leaves and roots, six handfuls, Wormwood, Tansie, Southern-wood of each four handfuls, the outer rinds of twelve Oranges and four Limons, prepared Worms and Snails of each one pound, Cloves bruised two ounces, being all cut and bruised pour upon them eight pound of White-wine, let them be distill'd in a cold still, and the whole water mixt. Or,

Take of filings of Steel one pound, fresh Strawberries six pound, put them into a gla∣zed pot, stirring them together, and let them stand a day, afterwards adde of English Rhubarb sliced one pound, the rinds of four Oranges sliced, pour upon them of White wine six pound, and distill them according to Art; let all the liquor be mixt together. The dose of this and of the former is three ounces twice in a day after the Electuary or any other medicine.

Take of Turmerick-roots, Rhubarb, of each one dram and a half, the Bark of Caper-roots, of Asarum-roots, of each half a dram, Extract of Gentian, and Centaury, of each one dram and a half, Salt of Wormwood four scruples, Water-cress-seeds half a dram, of Rocket half a scruple, Elixir Proprietatis one dram, gum Ammoniacum dissolved in the water of Earth-worms what will suffice to make a mass, form it into small Pills, the dose is half a dram evening and morning, drinking after it three ounces of the distilled water.

Sylvius doth much magnifie for cure of the Jaundies, the Decoction of Hemp-seed in milk, and the solution of Sope, and from thence endeavours to establish his own Hypothesis (as we have above intimated) whereby he endeavours to deduce the Aetiolo∣gie of the Jaundies, rather from an alienation of the choler, than from the obstructi∣on of its passages.

2. The Second Indication respecting the altering or tempering of the blood, by which it may breed but moderately, and duly separate the choler, requires Medicines of that sort, which depress the Sulphur and fixt salt too much advanced. For these ends, I know not by what chance or conduct Medicines endowed with a volatile salt, as Worms, Snails, Millepedes, yea Lice, Dungs of fourfooted Beasts, and Fowl, are brought into practice for curing the Jaundies, and not only prescribed by Empiricks, but the more famous Physicians: These sometimes by themselves, but oftener joyn'd with Purgers and Deoppilatives, become the chief Ingredients in Compositions against the Jaun∣dies.

Fonseca prescribes Goose-dung gathered in the Spring-time and dryed, as also the white excrement of Pullets, of both which let the Powder be given in a convenient vehicle from half a dram to a whole one.

Take powder of Earth-worms prepared, of Goose-dung, of each three drams, Ivory, yellow Sanders, of each half a dram, Saffron one scruple, make a powder, divide it into six parts. One to be taken every morning with some appropriate liquor. To the Apozeme, or Anticterical Tincture prescribed above, Earth-worms, Goose-dung, and also Sheeps∣dung are profitably added.

Take Millepedes fresh and alive from 50 to 100. Saffron half a Scruple, Nutmeg a scruple, bruise them together, and infuse them in Water of Celandine four ounces, of Earth worms two ounces, express them strongly, and drink it: after this manner take it first once, then twice in a day for a week.

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The vulgar and Empirical remedy with us is, that Nine quick Lice be taken in a morning for five or six dayes, by which remedy they report to me many to be cu∣red (whenas other remedies effected little) which truly can help by no other means than by restoring the volatile Salt depressed in the blood.

Upon the same account of succour even in this disease the flowers of Sal Armoniac, the volatile Salts of Amber, Harts-horn, Soot, in like manner their Spirits are fre∣quently administred with great success.

Take powder of Earth-worms prepared two drams, Species Diacurcumae one dram, flower of Sal Armoniac half a dram, Salt of Amber a scruple, Extract of Gentian one dram, Saffron one scruple, Gum Ammoniacum dissolved in water of Earth-worms what suffices, make a mass, and form it into small Pills; the Dose is three or four, morning and evening, drinking after it three ounces of the Julep before prescribed.

Take Spirit of Harts-horn tinctured with Saffron three drams; Dose from 15 drops to 20. with the distilled water prescribed above.

In this Class of Medicines by which the icterical distempers of the blood are to be corrected, steel'd remedies do also challenge their place by right; for these afford notable help, not so much by unlocking the obstructions of the bowels, as by de∣pressing the rage of the Sulphur, and fixt Salt, and by volatilizing the blood, in the Jaun∣dies, no less than in other cachectical distempers.

Wherefore, to the Decoction, or Tincture, or Infusion above prescribed, is pro∣perly added the filings of Iron, or the prepared powder thereof (its mineral con∣sistence being some wayes opened) or the vitriolic Salt extracted; from hence it is, that Medicinal waters heal even to a miracle those sick of the Jaundies, that had been de∣spaired of; although these drunk in a very large quantity, inasmuch as they pass through all the vessels, do also open the passages of the Liver, however shut up.

Therefore also even Preparations of Steel are added to the Electuary, Pills and Powders above recited, one while this, another while that, in due proportion. More∣over the Syrup thereof given twice a day to one spoonfull, in three ounces of Apozeme or water against the Jaundies; also tincture of Steel to twelve or fifteen drops may be administred in the same manner.

In the last place we may annex to this classis of altering Medicines those things which not taken inwardly, but outwardly applyed, and by contact, used to the very urine of the Patient are held to cure this disease.

As to the former, a remedy often tryed by the vulgar, is a living Tench-fish, whose Scales and outer superficies do resemble a yellow colour, applyed to the right Hypochondria, or Stomach according to some, (to the soles of the feet, according to others) whence a sudden flight of this disease is expected; hence although many pro∣mise themselves a sure cure, it hath often deceived me.

Another cure of the Jaundies at a distance is said to be done by I know not what sympathy or secret manner of working.

Take the fresh Ʋrine of the Patient made at one time, of the ashes of the Ash-tree searced, as much as suffices to reduce it into Paste, which may be formed into three equal balls, to be placed in a place shut, near the hearth or Stove; as these dry and harden, the Jaundies will vanish; after this course, I have known this inveter ate disease happily cured, although resisting many other remedies; the practice thereof is very familiar with the Vulgar.

If of a certain it could be made manifest that this effect doth for the most part happen, and the reason of it be inquired into; in the first place we ought to sup∣pose a consent or sympathy of the spirits and other particles in the animated blood, with other symbols inmates of the fresh urine; and that they immediately are af∣fected in the like manner with these. Notwithstanding it is evident enough that a lixivial Salt mingled with urine, doth presently set free the volatile salt formerly sub∣dued or enwrapt in other particles; as is plainly seen in distillation of Urine, which if you urge by it self with a sand-heat, nothing but phlegm will arise; but adde the calx of Tartar, or Ashes, immediately the Spirit and volatile Salt will come forth: wherefore, that Empirical administration being administred, at the same time, both in the Icterical urine, and also in the blood of the Patient, the volatile Salt escapes out of the power of the fixt Salt and the Sulphur, and for that cause the icte∣rical

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distemper of the Blood is put to flight. Also upon the same reason is built ano∣ther sympathetical cure of the Jaundies, whereof Phil. Grulingius and Felix Platerus do make mention, viz. the sick party pissing upon Horse-dung while it is hot, hath cured many of the Jaundies; inasmuch as the fixt Salt of the Urine, and thereby the fixt Salt of the icterical blood of the patient, is altered by the volatile Salt of the fresh dung, and reduced into its due temperature.

3. The third Curatory indication vital institutes a convenient course of Diet, and moreover Cordials and Anodynes, of both which there is frequent need.

As to what relates to the former, Food in this disease, more than in any other ought to be medicinal. For Vegetables and their parts, styled commonly Hepatick remedies, are boyled in the broths of these Patients. And these also are wont to be made instead of other flesh, of Worms, or Snails, (which are accounted Antidotes against the Jaundies.) Moreover Ale, and other ordinary drinks are impregnated with infusion of Medicaments.

Take of the roots of stinging Nettles, of Strawberries, of each an ounce and half, Eriygo-roots candied one ounce, Ivory and Harts-horn, of each two drams, Earthworms cleansed twenty, a Crust of White-bread, Mace two drams, boyled in two pound of water to one pound, strain it through Hippocrates sleeve, to which adde Diasantalon half a dram, make broath, whereof take from four ounces to six, twice in a day: for ordinary drink, fill a Tub of four Gallons with Beer, after it hath wrought, put in the follow∣ing Bag.

Take the tops of Roman Wormwood, white Horehound dryed, of each two handfuls, the roots of sharp pointed Docks six ounces, of the Bark of Ash, of Barberries, of each 3 ounces, the outer Rinds of eight Oranges, and of four Limons, being sliced and bruised, let them be prepared according to Art.

Since many sick of the Jaundies are usually affected with a great languishing, and frequent faintings of the Spirits, they have also need of cordial Remedies.

Take of small Aqua Mirabilis eight ounces, water of Earth-worms four ounces, Syrup of Orange-peels two ounces, mingle them, the dose two or three ounces.

Moreover, they who are troubled with this disease, do very much suffer with pain sometimes very troublesome in the night, and are often obnoxious to waking; where∣fore also Anodynes come into use for administration.

Take of Aqua Mirabilis, water of Earth-worms, of each one ounce, Diacodium six drams, Tincture of Saffron half an ounce, the dose one or two spoonfuls late at night, if sleep be wanting.

Take of Laudanum tartarizated two drams, Aqua Mirabilis two ounces, Syrup of Clove-gilly-flowers one ounce, mix them, the dose is one spoonfull after the same man∣ner.

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