Ideas, either through its own passions, or other ex∣ternal accident, or deprav'd matter. So we say with Hel∣mont, that though there may be millions of irritative ma∣terial causes, or external accidents, yet the sole formal cause is the vital Spirit, which either being enrag'd, transport∣ed or suppressed, frame diseases accordingly. Patients are alter'd according to the energy and design of the Agents. Now in all bodies the vital Spirit must be the Agent, (as the Excellent Sir Francis Bacon saith in his Natural Histo∣ry, lib. 1. Exper. 98. being the only active part of the bo∣dy, the rest being but a dead lump when that is gone, or become unactive, absolutely insensible, and consequently uncapable of Disease or Cure. When this Agent acts vi∣gorously placidly, and without disturbance, he doth all things for the best; but if disturb'd, it stirreth up such a hurry and disorder in him, that he mouldeth pretern u∣ral Forms or Textures; and thence we affirm, that the cause of life and health, when in order, is the cause of sickness and death when in disorder. Now the vital Spi∣rit is the occasion of diseases of it self, as it admits of ill Impresses or Ideas, by the senses from without, as we see the same Spirit that is now pleasant and sedate, will on a sudden degenerate into passions of different, nay, con∣trary effects, according to the nature of the irritative cause from without, or the diseased matter disturbing the free exercise and government of the vital Spirits within variously, according to the quantity, quality, and tex∣ture of such morbifick matter; But it cannot be said, that they are first or last in point of time, they being as A∣gent and Patient, and therefore corival and co-existent, though in respect of the irritative cause, we compute them one before another. For the vitals can be no sooner from their duty, but matter will in some measure degenerate for want of its due preserver; and there can be no of∣fensive