The loynes and reynes haue ache and passion, that come somtime of swelling, Sometime of repletion of humoures, sometime of winde and ventositie, and sometime of the stone. All these bréede full great ache and griefe, and namely if heate be the cause: and the signe there∣of is the high coulour of vrine, sharpe ache and pricking. If colde be the cause, the vrine is rawe, and the ache slowe. The stone and grauell, and other diners superfluities breed osle in the reynes: & that commeth namely of drinke of sli∣mie water, and of grose dyet. For ther∣of commeth stoppings in the reynes or in the bladder, and sometime chaungeth into substaunce of stones or grauell, by working of strong heate. They yt haue the stone, haue manye disaduauntages, that is to wit, difficultie of pissing, with Colica passio, and other such: for by stop∣ping of the stone, the wayes of pissing be stopped, and then commeth Stranguria, when a man passeth with difficultie dropping meale. Sometime the wayes be all stopped, and pissing is all for∣bode, and that euill is called, Dissuria: for of gleymie humoures in the reynes and in the bladder commeth the stone, in young men, namely in the reynes, and in children in the bladder, for the necke of their bladder is straight, and letteth the passage of the matter, and so the stone is bred, as Costantine saith. Also in chil∣dren the vrine is thicke, because of glei∣mie dyet, and gleymie things is more a∣ble to be rouled & to cleaue togethers: and therefore ofte the stone bréedeth in small children. And if the stone or the matter be in the reynes, it is knowen by sléeping of the foote and leg on the lefte side. And if it be in the bladder, the ache is about the share and twiste, betwéene the genitours, and the hole at the ridge bones ende. Also the grauell that com∣meth of the reynes be redde, and if they come of the bladder they be white: and a stone that is bred of gleymie humour, is easely dissolued and brought out: and if it be bred of grauell, it is hard to dis∣solue and to be broken. And in women the stone bréedeth more seldome than in men, for the wayes be more large, and heate and drinesse more féeble, to make the humours rotlewe: and also oft pur∣gations, for they be purged of many su∣perfluities by mēstrual bloud. He yt hath this euill, shall be purged in this man∣ner: They shall be ofte bathed in hotte baths, that dissolue, and open: and they shall be fed with meate and drink that is easie for to desie, & cōforted with me∣dicines, that dissolue, and open, & cleanse: and they shall be occupied with some bu∣sinesse: and sometime they shall be ta∣ken to surgerie, and namely children, and then young folke, for in age cutting is perillous, for after fortie yeare this E∣uill is incurable, as it is sayd in Aphor. After fortie yeare, be that hath the stone is not saued. Sometime commeth vn∣willyng pissing, and that euill is called Diampnes, or Diabethica passio. And Constantine sayeth, that it commeth of default of vertue of with-holding: for there is great strong drawing of hu∣mours to the reynes, and great super∣fluitie commeth to the bladder, the which the bladder not being able to sustain, put∣teth out with pissing. Also sometime it commeth of softening of sinewes, and of slaking of brawnes in the necke of the bladder. Sometime of heauinesse of sléepe, and of multitude of humours, as it fareth in children that vnknowenlye pisse in their beddes, and in dronken people: and it is the propertie of them that haue this Euill, to bée a thrist alwaye, and maye vnneth haue wa∣ter inough, as Constantine sayeth: and therefore as they drinke the water, so they pisse it. Sometime it chaunceth of a humor that stoppeth sodainly yt wayes of the pisse and wringeth out by strength of pressing the moysture that is therein conteyned. To them that haue this foule euill, things that slake heate be néedfull, and sharpe sauouring things, that com∣fort and quench the heate of the reynes, and bringeth the sinewes that be softe∣ned to their owne due state, and this is done by drenches, electuaries, plaisters, & oyntments. But a wise leach and a re∣die, shall alway beware, that he lay not in this case, medicines that be too moyst, for they making it more softe shoulde