Report on Poliomyelitis Vaccine Produced by the Cutter Laboratories

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Isolation of Poliomyelitis virus
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vaccine by Public Health Service or other laboratories over the 90-day A
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period of study..
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Within the study period poliomyelitis virus was isolated from the stools
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of 28 cases who had been vaccinated with Cutter vaccine from the six lots, - -
and from the stools of 32 cases developing in household contacts of persons
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vaccinated from these six lots. Type I virus was identified from 59 of
these 60 individuals; however, this finding by itself would not ordinarily
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be significant, because it is not unusual to isolate Type I virus from a
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high percentage of cases of poliomyelitis and their contacts in natural
outbreaks. The significance of the laboratory identification of Type I
virus lies in the correspondence between the type virus found in the
three lots of vaccine and in the stools of the 59 individuals.
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The data on the development of poliomyelitis among individuals who received
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Cutter vaccine from 6 of 17 distribution lots, on the development of the
disease among close associates of those who received that vaccine, and on _
the isolation of Type I poliomyelitis virus both from individuals who may I
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have been infected and from some of the 6 distribution lots, indicate that
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infective amounts of live virus were contained in some distribution lots
of Cutter vaccine. o
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Plant Production 0
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The plant study dealt with the two possible sources of infective amounts
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of live poliomyelitis virus in the vaccine -- contamination and inadequate