Report on Poliomyelitis Vaccine Produced by the Cutter Laboratories

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The number of confirmed cases (4.6) observed in the 6 lots with the highwr
attack rate of poliomyelitis, was larger than the number of cases (5 --
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to 10) expected to have occurred naturally. During the 90-day period
of study, 46 of the 4 9 cases associated with the 6 lots occurred within
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the incubation period of the disease following vaccination. The site
of injection was the site of first paralysis in a high proportion of
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the cases. These facts warrant a presumption that the cause of the g =
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disease in some of the individuals who received vaccine from these 60
lots was infection with poliomyelitis virus contained in these lots of 0
vaccine produced by the Cutter Laboratories.
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Attack rates of the disease in individuals receiving vaccine from the
remaining 11 of the 17 lots were not higher than could be expected nor
1 -did the other data relating to the character of the disease suggest a
causal relation between vaccination with material from these lots and
the occurrence of poliomyelitis.0
Poliomyelitis in close associates of vaccinated children
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There were 90 cases of poliomyelitis in household contacts occurring
within 49 days after vaccination of a household associate with Cutter
vaccine. In 71 of these cases the occurrence of the disease could be--
associated with specific distribution lots of vaccine. Among the 71o
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cases, 57 were associates of persons who had been vaccinated with material
from the 6 distribution lots, while 14 cases were associates of persons
who had been vaccinated with material from the remaining 11 lots. These
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the ccurenc ofpolomyeiti.-0

data support the initial presumption that infective amounts of live
virus were contained in the six lots. (-C
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