AIDS Medicines: In Development, Drugs and Vaccines

Cytokines
DRUG NAME COMPANY INDICATION U.S. DEVELOPMENT STATUS
Betaseron~ Triton Biosciences ARC, AIDS Phase I
(Recombinant (Alameda, CA)
Human Interferon
Beta) with
Retrovir* (AZT)
EPREXTM Ortho Pharmaceutical Corp. severe anemia assoc. w/AIDS Treatment IND
Recombinant (Raritan, NJ) and Retrovir therapy
Human
Erythropoietin
Granulocyte Immunex Kaposi's sarcoma Phase I/II
Macrophage Colony (Seattle, WA)
Stimulating Factor
(GM-CSF) with
Roferon~.At
(Interferon alfa-2a)
and Retrovir*
(AZT)
Granulocyte Sandoz leukopenia associated with Phase II/III
Macrophage Colony (East Hanover, NJ) HIV infection, ARC, AIDS
Stimulating Factor Genetics Institute
(GM-CSF) (licensor)
(Cambridge, MA)
Schering-Plough
(Madison, NJ)
Granulocyte Sandoz CMV retinitis Phase II/III
Macrophage Colony (East Hanover, NJ)
Stimulating Factor Genetics Institute
(GM-CSF) with (licensor)
Cytovene~ (Cambridge, MA)
(Ganciclovir) Schering-Plough
(Madison, NJ)
Granulocyte Sandoz AIDS Phase II/III
Macrophage Colony (East Hanover, NJ)
Stimulating Factor Genetics Institute
(GM-CSF) with (licensor)
Retrovir* (AZT) (Cambridge, MA)
Schering-Plough
(Madison, NJ)
Interleukin-2 Hoffmann-La Roche Kaposi's sarcoma, AIDS Phase II
(IL-2) with (Nutley, NJ)
Retrovir* (AZT)
Interleukin-2 Hoffmann-La Roche HIV, ARC, AIDS Phase I
(IL-2) with (Nutley, NJ)
Retrovir* (AZT) Immunex
(Seattle, WA)
Intron A~t Schering-Plough AIDS Phase II
(Interferon-alpha 2b) (Madison, NJ)
with Retrovir*
(AZT)
NeupogenTM Amgen ARC, AIDS Phase I
(Granulocyte (Thousand Oaks, CA)
Colony Stimulating
Factor) with
Retrovir* (AZT)
Roferon~-At Hoffmann-La Roche ARC, AIDS Phase II
(Interferon alfa-2a) (Nutley, NJ) (NIAID Trials)
with Retrovir*
(AZT)

Timunox' Immunobiology HIV infection Phase II
Thymopentin Research Institute
(TP/5) (Clinton, NJ)