[AIDS Medicines in Development]

Cytokines
DRUG NAME COMPANY INDICATION U.S. DEVELOPMENT STATUS
Neupogen'TM Amgen ARC, AIDS Phase I/II
(Granulocyte (Thousand Oaks, CA)
Colony Stimulating
Factor) with
Retrovir~ (AZT)
Proleukin~ Cetus ARC, AIDS Phase I/II
(IL-2) with (Emeryville, CA)
Retrovir~ (AZT)
Roferon~-At Hoffmann-La Roche Kaposi's sarcoma, AIDS Phase II
(Interferon alfa-2a) (Nutley, NJ) (NIAID Trials)
with Retrovir~
(AZT) ARC Phase I
(NIAID Trials)
Wellferon Burroughs Wellcome Kaposi's sarcoma Phase II/III
(Alpha Interferon) (Rsch. Triangle Park, NC)
with Retrovir~
(AZT)
Imm unomodulators
DRUG NAME COMPANY INDICATION U.S. DEVELOPMENT STATUS
AS-101 Wyeth-Ayerst ARC, AIDS Phase I/II
(Philadelphia, PA)
AS-101 with Wyeth-Ayerst ARC, AIDS Phase I/II
Retrovir~ (AZT) (Philadelphia, PA)
Bropirimine Upjohn Kaposi's sarcoma Phase II
ABPP (Kalamazoo, MI)
EL 10 Elan Corp. HIV infection Phase I/II
DHEA (Gainesville, GA)
Gamiune~-Nt Cutter Biological pediatric HIV infection Phase II/III
Human Serum (Berkeley, CA)
Globulin
Gamiune~-Nt Cutter Biological ARC, AIDS Phase II/III
(Human Serum (Berkeley, CA)
Globulin) with
Retrovir~ (AZT)
Imuthiol Connaught Laboratories HIV infection, ARC, AIDS Phase II/III
Diethyl- (Swiftwater, PA)
dithiocarbamate pediatric HIV infection Phase I/II
Lentinan Lenti-Chemico Pharmaceuticals HIV positive asymptomatic and Phase I/II
b-(1-3)glucan (Teaneck, NJ) symptomatic, ARC, AIDS, pediatric
AIDS
Thymic Humoral Adria Laboratories HIV positive Phase I
Factor (Dublin, OH)
TimunoxTM Immunobiology HIV infection Phase II/III
Thymopentin Research Institute
(TP/5) (Clinton, NJ)
Anti-infectives
DRUG NAME COMPANY INDICATION U.S. DEVELOPMENT STATUS
ABCD~ Liposome Technology PCP prophylaxis Phase I
Liposome- (Menlo Park, CA)
encapsulated
Amphotericin B

ABLC Liposome Co. cryptococcal meningitis Phase II
Amphotericin B (Princeton, NJ)
Lipid Complex
BW566C80 Burroughs Wellcome PCP treatment/prophylaxis, Phase II
(Rsch. Triangle Park, NC) toxoplasmosis treatment