[AIDS Medicines in Development]

Anti-infectives
DRUG NAME COMPANY INDICATION U.S. DEVELOPMENT STATUS
Clindamycint with Upjohn PCP treatment Phase I/II
Primaquine (Kalamazoo, MI)
Dapsone with Jacobus Pharmaceuticals PCP prophylaxis Phase II/III
NebuPent~ (Princeton, NJ)
(Aerosol
Pentamidine
Isethionate)
Dapsone with Jacobus Pharmaceuticals PCP prophylaxis Phase III
Retrovir~ (AZT) (Princeton, NJ)
Daraprim~ Burroughs Wellcome toxoplasmosis prophylaxis Phase III
Pyrimethamine (Rsch. Triangle Park, NC)
Diclazuril Janssen Pharmaceutica cryptosporidiosis Phase I
(Piscataway, NJ)
Mycostatin~t Bristol-Myers Squibb prevention of oral candidiasis Phase III
Pastille (New York, NY)
Nystatin Pastille
NebuPent~ Fujisawa Pharmaceutical PCP treatment Phase III
Aerosol Pentamidine (Deerfield, IL) (Orphan Drug)
Isethionate
Nizoral~ Janssen Pharmaceutica candida esophagitis Phase III
Ketoconazole (Piscataway, NJ)
(suspension)
Piritrexim Burroughs Wellcome PCP treatment Phase I/II
(Rsch. Triangle Park, NC)
PneumopentTM Fisons Corporation PCP prophylaxis application submitted
Aerosol Pentamidine (Bedford, MA)
Isethionate
Rifabutin Adria Labs MAI prophylaxis Phase III
(Columbus, OH)
SCH39304/42427 Schering-Plough opportunistic fungal infections, Phase II/III
(Madison, NJ) including aspergillosis, candidiasis,
cryptococcal meningitis; empirical
treatment in neutropenic sepsis
Septra~ Burroughs Wellcome PCP prophylaxis Phase III
Trimethoprim and (Rsch. Triangle Park, NC)
Sulfamethoxazole
Spiramycin Rhone-Poulenc cryptosporidial diarrhea Phase II/III
Pharmaceuticals
(Princeton, NJ)
Sporanox~ Janssen Pharmaceutica maintenance therapy for Phase III
Itraconazole- (Piscataway, NJ) cryptococcal meningitis,
R51211 histoplasmosis
TLC-G-65 Liposome Co. MAI infection Phase I
Gentamicin (Princeton, NJ) (Orphan Drug)
Liposome
(injection)
Other
DRUG NAME COMPANY INDICATION U.S. DEVELOPMENT STATUS
Megace~ t Bristol-Myers Squibb treatment of anorexia and cachexia Phase II/III
Megestrol Acetate (New York, NY) associated with AIDS
Mesalamine Norwich Eaton inflammatory bowel syndrome Phase I/II

(Norwich, NY) associated with HIV infection, ARC,
AIDS
Sandostatin~ t Sandoz HIV-related diarrhea Phase II/III
Somatostatin (East Hanover, NJ)