Orphan Drugs: In Development

DISEASE
Cancer, Colorectal
(continued)

DRUG NAME
Isovorin
1-leucovorin

SPONSOR
Lederle
(Wayne, NJ)

FDA OFFICIAL DESIGNATION
for use in combination with 5-FU in
the palliative treatment of
metastatic adenocarcinoma of the
colon and rectum

DEVELOPMENT
STATUS
application submitted

Roferon~-A Hoffmann-La Roche for use in combination with 5-FU Phase III
interferon alfa-2a (Nutley, NJ) for the treatment of advanced
(recombinant) colorectal carcinoma
trimetrexate U.S. Bioscience treatment of metastatic colorectal Phase III
glucuronate (West Conshohocken, PA) adenocarcinoma
XomaZyme~-791 Xoma treatment of metastatic colorectal Phase I

anti-TAP-72

(Berkeley, CA)

adenocarcinoma

immunotoxin
Cancer, Photofrin~ QLT Phototherapeutics photodynamic therapy in patients Phase III
Esophageal porfimer sodium (Pearl River, NY) with primary or recurrent obstructing (either partially or completely)
esophageal carcinoma
Cancer, ImmuRAID-AFP Immunomedics detection of alpha-fetoprotein- Phase II
Germ Cell technetium Tc-99m (Warren, NJ) producing germ cell tumors
murine MAb to
human AFP
ImmuRAID-HCG Immunomedics detection of HCG-producing tumors Phase II
technetium Tc-99m (Warren, NJ) such as germ cell and trophoblastic
murine MAb to hCG cell tumors
Cancer, trimetrexate U.S. Bioscience treatment of metastatic carcinoma Phase III
Head and Neck glucuronate (West Conshohocken, PA) of the head and neck (i.e., buccal
cavity, pharynx and larynx)
Cancer, Hepatic ImmuRAID-AFP Immunomedics detection of hepatocellular Phase II
technetium Tc-99m (Warren, NJ) carcinoma and hepatoblastoma
murine MAb to
human AFP
Cancer, Leukemia 2'-chloro-2'- St. Jude Children's treatment of acute mveloid Phase I/II

deoxyadenosine

Research Hospital
(Memphis, TN)

leukemia

5-AZA-2'- Pharmachemie B.V. treatment of acute leukemia Phase II
deoxycytidine (Haarlem,
The Netherlands)
Agrelin~ Roberts Pharmaceutical treatment of thrombocytosis in Phase III
anagrelide (Eatontown, NJ) chronic myelogenous leukemia (CML)
Amsidyl Warner-Lambert treatment of refractory and Phase III
amsacrine (Morris Plains, NJ) recurrent acute adult leukemia
chlorodeoxy- R.W. Johnson treatment of chronic lymphocytic Phase II
adenosine (2CdA) Pharmaceutical leukemia
Research Institute
(Raritan, NJ)
chlorodeoxy- R.W. Johnson treatment of hairy cell leukemia application submitted
adenosine (2CdA) Pharmaceutical
Research Institute
(Raritan, NJ)
Erwinase~ Porton Products Ltd. treatment of acute lymphocytic application submitted
erwinia L-asparaginase (Maidenhead, England) leukemia (ALL)
Idamycin Adria treatment of acute lymphoblastic Phase III
idarubicin HCL for (Columbus, OH) leukemia in pediatric patients
injection
ImmuRAIT-LL2 Immunomedics treatment of B-cell leukemia and Phase II
iodine 131-intact IgG (Warren, NJ) B-cell lymphoma
MAb
INTRON~ A Schering-Plough treatment of chronic myelogenous Phase III
interferon alfa-2b (Madison, NJ) leukemia (CML)
(recombinant)
MAb MDX-11 Medarex adjunctive treatment of acute Phase I/II

(Princeton, NJ)

myelogenous leukemia
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