Orphan Drugs: In Development

DISEASE
Acne Rosacea

DRUG NAME
MetroGel~
metronidazole
(topical) gel

COMPANY
Curatek Pharmaceuticals
(Elk Grove Village, IL)

INDICATION
treatment of acne rosacea

Acquired Immune Retrovir~ Burroughs Wellcome treatment of AIDS
Deficiency Syndrome zidovudine; AZT (Rsch. Triangle Park, NC)
(AIDS)
AIDS-Related Complex Retrovir~ Burroughs Wellcome treatment of AIDS-related complex (ARC)
(ARC) zidovudine; AZT (Rsch. Triangle Park, NC)
Alpha-1-Proteinase Prolastin~ Miles Inc. replacement therapy in the alpha-1-proteinase
Deficiency alpha-1-proteinase (Berkeley, CA) inhibitor congenital deficiency state
inhibitor
Amenorrhea Lutrepulse~ Ortho Pharmaceutical Corp. induction of ovulation in women with
gonadorelin acetate (Raritan, NJ) hypothalamic amenorrhea due to a deficiency or
absence in the quantity or pulse pattern of
endogenous GnRH secretion
Anemia EPOGEN~ Amgen treatment of anemia associated with chronic renal
epoetin alfa (Thousand Oaks, CA) failure, including patients on dialysis and not on
--- -- --- -- --- -- --- -- --- -- --- -- --- -- --- -- --- -- --- -- --- -. d ia ly s is
PROCRIT~ Ortho Biotech
epoetin alfa (Raritan, NJ)
EPOGEN~ Amgen treatment of anemia in AZT-treated HIV-infected
epoetin alfa (Thousand Oaks, CA) patients
PROCRIT~ Ortho Biotech
epoetin alfa (Raritan, NJ)
[PROCRIT~ was approved for marketing underAmgen's epoetin alfa PLA. Amgen manufactures the product
for Ortho Biotech. Under an agreement between the two companies, Amgen licensed to Ortho Pharmaceutical
the US. rights to epoetin alfa for indications for human use excluding dialysis and diagnostics.]
Antithrombin III ATnativ Kabi Pharmacia treatment of patients with hereditary AT-III
(AT-III) Deficiency antithrombin III (Piscataway, NJ) deficiency in connection with surgical or
(human) obstetrical procedures or when they suffer from
thromboembolism
THROMBATE~ III Miles Inc. replacement therapy in congenital deficiency of
antithrombin III (Berkeley, CA) AT-III for prevention and treatment of thrombosis
(human) and pulmonary emboli
Blepharospasm Oculinum~ Allergan treatment of blepharospasm
botulinum toxin type A (Irvine, CA)
Cancer, Bone leucovorin calcium Lederle for rescue use after high-dose methotrexate
(Wayne, NJ) therapy in the treatment of osteosarcoma
Methotrexate Lederle treatment of osteogenic sarcoma
methotrexate sodium (Wayne, NJ)
Cancer, Colorectal leucovorin calcium Lederle for use in combination with 5-FU for the
(Wayne, NJ) treatment of metastatic adenocarcinoma of the
colon and rectum
Cancer, INTRON~ A Schering-Plough treatment of AIDS-related Kaposi's sarcoma
Kaposi's Sarcoma interferon alfa-2b (Madison, NJ)
(recombinant)
Roferon~-A Hoffmann-La Roche treatment of AIDS-related Kaposi's sarcoma
interferon alfa-2a (Nutley, NJ)
(recombinant)
Cancer, Leukemia Fludara~ Berlex treatment of chronic lymphocvtic leukemia (CLL),

fludarabine phosphate

(Wayne, NJ)

including refractory CLL

Idamycin~ Adria treatment of acute myelogenous leukemia (AML),
idarubicin HCL (Columbus, OH) also referred to as acute nonlymphocytic
for injection leukemia (ANLL)
Nipent~ Warner-Lambert treatment of hairy cell leukemia
pentostatin (Morris Plains, NJ)

Novantrone~
mitoxantrone HCL

Lederle
(Wayne, NJ)

treatment of acute myelogenous leukemia (AML),
also referred to as acute nonlymphocytic
leukemia (ANLL)

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