Orphan Drugs: In Development

DISEASE Acne Rosacea DRUG NAME MetroGel~ metronidazole (topical) gel COMPANY Curatek Pharmaceuticals (Elk Grove Village, IL) INDICATION treatment of acne rosacea Acquired Immune Retrovir~ Burroughs Wellcome treatment of AIDS Deficiency Syndrome zidovudine; AZT (Rsch. Triangle Park, NC) (AIDS) AIDS-Related Complex Retrovir~ Burroughs Wellcome treatment of AIDS-related complex (ARC) (ARC) zidovudine; AZT (Rsch. Triangle Park, NC) Alpha-1-Proteinase Prolastin~ Miles Inc. replacement therapy in the alpha-1-proteinase Deficiency alpha-1-proteinase (Berkeley, CA) inhibitor congenital deficiency state inhibitor Amenorrhea Lutrepulse~ Ortho Pharmaceutical Corp. induction of ovulation in women with gonadorelin acetate (Raritan, NJ) hypothalamic amenorrhea due to a deficiency or absence in the quantity or pulse pattern of endogenous GnRH secretion Anemia EPOGEN~ Amgen treatment of anemia associated with chronic renal epoetin alfa (Thousand Oaks, CA) failure, including patients on dialysis and not on --- -- --- -- --- -- --- -- --- -- --- -- --- -- --- -- --- -- --- -- --- -. d ia ly s is PROCRIT~ Ortho Biotech epoetin alfa (Raritan, NJ) EPOGEN~ Amgen treatment of anemia in AZT-treated HIV-infected epoetin alfa (Thousand Oaks, CA) patients PROCRIT~ Ortho Biotech epoetin alfa (Raritan, NJ) [PROCRIT~ was approved for marketing underAmgen's epoetin alfa PLA. Amgen manufactures the product for Ortho Biotech. Under an agreement between the two companies, Amgen licensed to Ortho Pharmaceutical the US. rights to epoetin alfa for indications for human use excluding dialysis and diagnostics.] Antithrombin III ATnativ Kabi Pharmacia treatment of patients with hereditary AT-III (AT-III) Deficiency antithrombin III (Piscataway, NJ) deficiency in connection with surgical or (human) obstetrical procedures or when they suffer from thromboembolism THROMBATE~ III Miles Inc. replacement therapy in congenital deficiency of antithrombin III (Berkeley, CA) AT-III for prevention and treatment of thrombosis (human) and pulmonary emboli Blepharospasm Oculinum~ Allergan treatment of blepharospasm botulinum toxin type A (Irvine, CA) Cancer, Bone leucovorin calcium Lederle for rescue use after high-dose methotrexate (Wayne, NJ) therapy in the treatment of osteosarcoma Methotrexate Lederle treatment of osteogenic sarcoma methotrexate sodium (Wayne, NJ) Cancer, Colorectal leucovorin calcium Lederle for use in combination with 5-FU for the (Wayne, NJ) treatment of metastatic adenocarcinoma of the colon and rectum Cancer, INTRON~ A Schering-Plough treatment of AIDS-related Kaposi's sarcoma Kaposi's Sarcoma interferon alfa-2b (Madison, NJ) (recombinant) Roferon~-A Hoffmann-La Roche treatment of AIDS-related Kaposi's sarcoma interferon alfa-2a (Nutley, NJ) (recombinant) Cancer, Leukemia Fludara~ Berlex treatment of chronic lymphocvtic leukemia (CLL), fludarabine phosphate (Wayne, NJ) including refractory CLL Idamycin~ Adria treatment of acute myelogenous leukemia (AML), idarubicin HCL (Columbus, OH) also referred to as acute nonlymphocytic for injection leukemia (ANLL) Nipent~ Warner-Lambert treatment of hairy cell leukemia pentostatin (Morris Plains, NJ) Novantrone~ mitoxantrone HCL Lederle (Wayne, NJ) treatment of acute myelogenous leukemia (AML), also referred to as acute nonlymphocytic leukemia (ANLL) 15

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Title
Orphan Drugs: In Development
Author
Pharmaceutical Research and Manufacturers of America
Canvas
Page 15
Publication
Pharmaceutical Manufacturers Association.
1992
Subject terms
reports
Item type:
reports

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"Orphan Drugs: In Development." In the digital collection Jon Cohen AIDS Research Collection. https://name.umdl.umich.edu/5571095.0504.010. University of Michigan Library Digital Collections. Accessed June 11, 2025.
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