Presidential Advisory Council on HIV/AIDS, International Issues Subcommittee [Transcript]

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1 how many different variants of the vaccine are in
2 development? The idea that only one vaccine would be used
3 around the world, that the different clades of the vaccine
4 and the virus require responses like --
5 DR. MANN: With the chairman's permission, I
6 would like to defer to the expert in my family, my wife,
7 Dr. (inaudible).
8 PARTICIPANT: Well, I think that one of the
9 first questions we have to answer really is -- a clade is a
10 family of viruses that seem to be found nominally in one
11 area of the world or another, and this is one of the first
12 questions you really want to answer with any vaccine. It
13 had to be answered with the polio vaccine, for instance.
14 It was found early in the trials for polio vaccine that you
15 actually needed three types of polio families in the
16 vaccine,
17 So one of the fundamental questions before we
18 can develop a vaccine that would be useful worldwide would
19 be to determine whether one vaccine, like the hepatitis B
20 vaccine, would work for the whole world, or are you going
21 to need a vaccine like rotovirus, where you need four types
22 of vaccines in the same vial.
23 So this is part of the iterative process. We
24 need to ask the question, can one vaccine work against
25 different types of viruses in the community, like we might
26 find in South Africa? Or do you need a vaccine, like the

FREILICHER & ASSOCIATES, COURT REPORTERS
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