[Fax to Alexandra Levine from Dani P. Bolognesi]

The vaccine field is one that is in crisis. It is so for several
reasons that are interconnected. The science base needed to develop a
vaccine is fragmentary. This in part derives from the obstacles that
HIV poses as a vaccine target but, importantly also because vaccine
research is unattractive and not well suDported. Consequently our best
minds and strongest efforts are not engaged in the quest for an HEV
vaccine.
Without a scientific base, it cannot be expected that private industry
become actively engaged in vaccine research and development. In fact,
the involvement of the private sector has been less than desirable and
is currently in sharp decline. This is also in part due to poor
economic incentives and perceived difficulties in working w.th
government agencies.
The offices of the Presi4ent and vice President can do a greac deal to
help invigorate this field. First and foremost a strong statement
must emerge that. vaccine against HIV is possible and has become a
national priority. The administration should also encourage our
leaders in government agencies to carry this message forward by making
vaccine research and development a scientific priority. The field must
be invigorated and fueled with sufficien: funds to meet the task.
Iinally, all means to encourage industry to participate, especially in
partnership with government, academia and private foundations is
paramount in importance. Inplicit in this statement is that
coordination and oversight of these activities is vital. To this end,
I would recommend that your group scrutinize the OAR repor:, not only
the vaccine section, but also related areas dealing with prevention
research and the role of animal models