[Electronic mail from Delia Enria]

PRO/AH> 3:rgentinian hemorrhagic fever vaccine

http://www.healthnet.org/...ed-hma/9703/msgooo89.html

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PRO/AH> Argentinian hemorrhagic fever
vaccine
* To: [email protected]
* Subject: PRO/AH> Argentinian hemorrhagic fever vaccine
* From: "Dra. Delia Enr"a" <[email protected]>
* Date: Thu, 13 Mar 199710:41:28 -0500
* Reply-To: [email protected]
~ Sender: [email protected]
ARGENTINIAN HEMORRHAGIC FEVER VACCINE
[see: Orphan drugs & vaccines 970311115701]
Date: Thu, 13 Mar 97 08:41:30 ARG
From: "Dra. Delia Enria" <[email protected]>
AHF vaccine is a good example of what an orphan vaccine means to people.
Candid 1, a live attenuated Junin virus vaccine, was developed through an
international cooperative project involving the Government of Argentina,
the Pan American Health Organization, the United Nations Development
Programme, and the United States Army Medical Research and Development
Command.
After completion of preclinical testing, the safety and
immunogenicity of this vaccine was established between 1985 and 1988 in the
United States and Argentina. Between 1988 and 1990, a prospective,
randomized, double-blind, placebo-controlled trial established the efficacy
of Candid 1 in the prevention of AHF in human volunteers aged 14-65
years: 95.5 %.
Since 1991, vaccination of the population at highest risk for
the disease was initiated. Limited quantities of vaccine available
(produced at the Salk Institute) restricted the areas targeted. Up to 1997,
more than 160,000 persons have received this vaccine and current studies
continue to reinforce previous observations concerning safety and efficacy
of this vaccine for adults of both sexes, and show that Candid 1 is highly
immunogenic when administered under field conditions. Persistence of
neutralizing antibodies was shown in 91.5% of a sample up to 84 months
following immunization.
So we have here an excellent vaccine for a disease
with a case-fatality rate of 15-30% when untreated, but with a low
incidence in a restricted geographic area of one country. At risk population
is estimated at 3,500,000 inhabitants.
It was originally projected (1978)that a plant for vaccine
production would be constructed in Pergamino, personnel trained, and the

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