Mathilde Krim, Mark Harrington, Scavalo’s Restaurant Following House Subcommittee Hearing on NIH Reauthorization

YOU DIDN"T HAVE PRIORITIES

109 no. we may come to that. first of all science does not answer questions,
it raises new ones. so?s broader...at same x fed. financed..should redirect
our lmtd resources to certain areas...now public policy amts to releasing
certain resources...amfar will become more of a lobbying effort...i think
we're ready already possible to design a program to answer a very specific
question or set of questions exploring maximizing drugs already have...all
elicit resistance..in combo have synergisitc...better early than late...on
basis of this alone could design clinical research, keep people alive and
well..already with the drugs we have using combination therpaies we could
people alive for 20 years...double
142 another area at the basic level is antisense molecules for
therapy...antisense molecules were not aborbed by cells efficiently..now we
know how to make them absorbed by cells...different viral vectors...these are
the two examples
171 you have to define the questions first and we could not define them five
years ago and the questions were not clear enough
186 this virus can probably go from cell to cell without floating through the
serum
193 protecting antisense from nucleases and making molecules that can go
through cel membrane either by themselves or put them through a vector
WHY MP a DIRTY WORD
201 it has to be defined, and the diferent between a mp in studies that
involve humans and vaccines has to be defined
HARRINGTON
213 The time isn't right for a Manhattan Project until there's a planning
process where people can evalute different models that are availabe and see
whether the targeted research model is appropriate for aids in toto. a lot of
us feel that there's a need for definite, discrete research projects with
clearly defined goals and time but to put the whole process under the aegis of
a Mp approach might be the worst of bureacratic over adminstration
micromanagement. so until there's, what we're trying to instead is create a
platform on which effective planning can take place. if a targeted initiative
is needed, if the s-l reforms go through, there will be a mechanism in place
to do targeted research. i don't think ther's any consensus about what mp
means in terms of biomedical--not physics, not industrial scale up, not
uranium procesing, not bomb fuselage technology, it's really different, it's
diferent from sending people to the moon. the only type of targeted programs
that have realy worked have been eradication programs like smallpox or
vaccinaton programs like polio, there's not a good model for a cure of an
infectious disease like hiv

WHY's POLIO MODEL DIFFERENT