[Minutes, Advisory Committee to the Director GP-160 Meeting (1992: Bethesda, Maryland)]

60

1 first boosting, in the sense that after the boosting
2 we developed very good T-Cell responses after the
3 first gp-160 boost, and also these are stimulation
4 index in the 300-400 range; and this is to inactivated
5 HIV.
6 This is inactivated whole virus. If I put
7 up gp-160, all these numbers would double. So these
8 are impressive immune responses. These are Delta
9 CPMs. You hear of 80,000. And they do persist -- the
10 T-Cell responses -- for a decent period of time. In
11 fact, this is one year between this bar and this bar.
12 Then when we boost people again, we can
13 boost them up again. Hence, their T-Cell responses
14 appear to be pretty good with boosting and sustained
15 in seronegatives. Next slide.
16 The antibody responses were much more
17 transient. This is the antibody response that
18 occurred after the first boost. That wanes one year
19 later. You can say, just follow the yellow bars here
20 -- wanes one year later.
21 We boost them again. It pops up, and it
22 starts to wane. Now it's interesting that the level
NEAL R. GROSS
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