[Minutes, Advisory Committee to the Director GP-160 Meeting (1992: Bethesda, Maryland)]

26

1 moderate immunosuppression. These are patients that
2 are still a significant time away from experiencing
3 clinical events, and one study examined the impact of
4 AZT on immune response. Next slide, please.
5 Now here is a summary, an almost
6 qualitative summary, of the data that has been
7 reported to date. Before we get into it, let me
8 provide a legend for the interpretation of this slide.
9 Across here are the four studies
10 previously described in design. Here are several of
11 the variables which have been measured in most of
12 these studies. The first four concentrate on immune
13 responses. Here's viral load and CD4 effect.
14 A positive connotes an increase, since in
15 all of these there is some -- in all of the immune
16 responses, natural infection -- natural infection, the
17 infecting virus, already produces some level of immune
18 response in each of these parameters.
19 Of course -- There is, of course, a
20 circulating viral load and a change in CD4 induced by
21 the natural infection. Therefore, a plus connotes
22 some increase in the parameter measured. A zero means
NEAL R. GROSS
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