[Minutes, Advisory Committee to the Director GP-160 Meeting (1992: Bethesda, Maryland)]

166

1 may run into substantial problems.
2 So I think you're taking a chance just to
3 let that all sort itself out. That's the model of the
4 super simple trials that we have used in some
5 settings.
6 I understand in respect what has been
7 done, but I want to adopt what many speakers have
8 said. There are no simple trials in AIDS. Okay?
9 The aspirin models or the other things
10 that people use and flash up on the board I don't
11 think are really the right metaphor. I think that
12 trials that we will have to do will have to have some
13 sort of attention, whatever the balance is.
14 There may be multiple therapeutic options
15 that you permit, but you're going to have to have some
16 algorithm, either for stratifying or permitting
17 consistency among all of the populations that are in
18 the study.
19 DR. ELLENBERG: You may take --
20 CO-CHAIRMAN FAUCI: Excuse me, Susan.
21 Just to see if I could pose a question based on Dr.
22 Broder's concern, and I pose it to Dr. Yusuf and
NEAL R. GROSS
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