[Memorandum from Daniel R. Lucey]

3. Mr Smith told Dr Vahey that she must understand that LCOL Redfield is under alot of pressure from the NIH and the scientific community (e.g. Dr Fauci was specifically mentioned) with regard to the gpl60 study. Mr Smith asked Dr Vahey if she is aware that the Army's HIV clinical trials are the best designed studies, and that some of the NIH's are poorly designed. 4. Mr Smith told Dr Vahey that she must understand that there are also financial pressures from the pharaceutical companies to consider. The outcome of LCOL Redfield's gpl60 study could influence the willingness and interest of other companies to work with LCOL Redfield, and other persons associated with this gpl 60 study, in the future. 5. Mr Smith also told Dr Vahey that she must understand that there are Congressional pressures on LCOL Redfield which must be considered with regard to his HIV vaccine trials. 6. Mr Smith also told Dr Vahey that she should present the HIV viral burden data on the same 15 patients that LCOL Redfield presented in Amsterdam, as well as the subgroup of the 7 patients that LCOL Redfield originally submitted on the abstract for the HIV vaccine meeting. Mr Smith also said Dr Vahey should look at the data by subgroups such as the patients in the Phase I study who were "early responders" compared with those who were "late responders". 7. Mr Smith said he wants Dr Vahey to get the data documenting the date of seroconversion for each of the patients. Mr Smith said this after Dr Vahey mentioned that patient #1 in the Phase I study had only been infected a relatively short time when he first started on the gpl160 injections and that this fact could possibly play a role in his clinical and laboratory evaluations. Dr Vahey referred to patient # 1 after Mr Smith asked her about patient # 1, as the patient that DrNelson Michael ad Dr Vahey had evaluated so extensively. Mr Smith asked Dr Vahey if she thought patient # 1 was an anomaly, compared with the other patients. Dr Vahey replied that patient # 1 was different than most of the other patients. At this point, Dr Vahey also mentioned that this patient was HIV-seropositive for a relatively short time before starting on the gpl60.

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Title
[Memorandum from Daniel R. Lucey]
Author
Lucey, Daniel R.
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Page 2
Publication
1992-08-24
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memorandums
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memorandums

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"[Memorandum from Daniel R. Lucey]." In the digital collection Jon Cohen AIDS Research Collection. https://name.umdl.umich.edu/5571095.0452.077. University of Michigan Library Digital Collections. Accessed June 3, 2025.
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