Summary Statement: ADARC Program Project on HIV/SIV Vaccine Development

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1 P01 AI43042-01 25 SEP
Ho, David D.
In summary, the strengths of the Primate Core include: (1) the excellent
research primate facility; (2) an exceptional expertise of the Principal
Investigator in non-human primate retrovirology; and (3) the well established
macaque models with SIV/SHIV infections. The impact on the achievement of the
stated objectives is rated as outstanding.
With regard to the budget, the costs for purchase of 170 new macaques for the
three projects, their per diem expenses, clinical studies, laboratory tests,
surgical biopsies, and necropsies, are not specifically described in the
primate core. In addition, the cost of some items, such as the total number
of animals per diem, blood draws, and clinical laboratories are not clear in
years 02-05 f the 5-year budget summary. Because of interactions (e.g., the
shared use of macaques, blood samples, or tissue specimens) and certain
laboratory supports (e.g., tests or assays) between the three projects and
central cores, there may be an overlap in the proposed budget.
REVIENER C: The primate animal core will provide support to investigators
from three projects in doing SIV/SHIV studies in rhesus macaques. Operation
of the facility, which is located in Tuexedo, NY, is being negotiated with
ADARC which has an active primate laboratory at this center since 1993. A
full-time staff consisting of animal research technicians and two
veterinarians provides animal care. Experimental protocols for the primates
are reviewed monthly, and the Institutional Animal Care and Use Committee
inspects the facility three times a year. The laboratory is prepared to house
singly-caged macaques under biosafety level "2+" conditions. The staff
members which will be responsible for veterinary care and experimental
procedures are experienced and highly skilled in various procedures in
primates. Work outlined by three different investigators involving SIV
infection of rhesus macaques over the proposed 5-year period will require
purchase of 170 animals. A review of animal requirements for the proposed
studies indicates that the animal requests are justified, and that the
facility is adequately prepared to assist with these projects.
A review of proposed primates to be purchased during the proposed 5-year
period of the project indicates that the projected expenses are moderate and
appropriate for the work outlined.
Human Subjects: code 10
Nomen and Minorities Representation: not applicable
Animal Welfare: code 30
Budget: The proposed budget is recommended for approval as requested.
IRG Action: This core was rated a p

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