Summary Statement: ADARC Program Project on HIV/SIV Vaccine Development

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1 P01 AI43042-01 24 SEP
Ho, David D.
three individual research projects will utilize the Primate Core's essential
services and facilities, so that the existence of the core is well justified.
The available resources are more than adequate to conduct the proposed
research, and the investigators and key personnel are well qualified and
experienced in primate SIV and SHIV work. The currently ongoing transfer of
ownership of the LEMSIP facilities should have no appreciable effect on the
successful completion of these projects, so that funding of this core is
entirely appropriate.
The core leader have a lengthy history of utilizing this core as part of
ongoing.primate projects, and possess the expertise, experience and
qualifications to successfully complete this work. The key staff members at
LEMSIP are equally well -experienced and skilled and are fully
equipped to carry out the proposed research.
The ADARC has had an active Primate Laboratory at LEMSIP for a number of
years. The facilities are more than adequate to perform the services required
by these projects.
The recommendation for this core is appropriate.
REVIENER B: The Primate Core is the largest facility among three central
cores in this application. The Primate Core is designed to both carry out
independent research and provide support and resources for the investigators
of this Program Project to study HIV/SIV vaccine development. The Primate
Core facility is located at the Laboratory for Experimental Medicine and
Surgery in Primates (LEMSIP) in Tuxedo, NY. LEMSIP is a USDA-inspected and
approved primate research facility. It is in compliance with federal
guidelines for animal care. The research protocol for the use of animals is
reviewed and approved by the IACUC of LEMSIP. The Primate Core will provide
the resources and facility to investigators of this application for their
SIV/SHIV studies in macaques. Approximately 1533 sq. ft. of the Infectious
Wing is used for housing of singly-caged macaques under biosafety level "2+"
conditions. Animal care and veterinary services are provided by the full-time
staff consisting of 15 animal technicians and two veterinarians. The
administrative staff of the Primate Core consists of the Principal
Investigator, Dr. Marx (15 percent effort) for coordination and oversight of
research and core services, an experienced Senior Primate Technician (40
percent effort) for support of animal studies, and a "To-be-Named" Research
Technician (100 percent) for research support.
The Principal Investigator of this core, Dr. P. Marx is an exceptionally well
qualified simian retrovirologist, scientist, and administrator. The Primate
Core ac~itty at LEISTIF (M wel established research environment) is rated as
excellent. The Primate Core has established macaque models with SIV and SHIV
infections, and virus stocks of SIVac, SHIV, and heterologous primary SIVs
for challenge studies proposed by the investigators.

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