ACTG Highlights

A phase I/I trial of hyperimmune IVIG vs AZT for proven infected infants
under three months of age.
Phase I trial of CD4-IgG in pregnant women and their newborns.
Phase I trials of CD4-IgG in HIV-infected infants and children.
Dose deposition study of aerosolized pentamidine.
Infections

Opportunistic

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The research strategy for opportunistic infections focuses on:
(1) expansior; of the number of active agents or combinations available to clinicians,
including validation of licensed agents for new indications;
(2) substitution of oral agents or parenteral agents with long half-lives for those
requiring frequent intravenous dosing;
(3) developing prophylactic approaches.
New Studies Planned for 1990
Compare 3 all-oral regimens for the outpatient management of mild PCP.
Dose-ranging study of oral ganciclovir in patients shedding CMV.
Study of Schering 39304 for cryptococcal meningitis.
Clindamycin/pyrimethamine vs sulfadiazine/pyrimethamine for acute toxoplasmic
encephalitis.
Clindamycin/pyramethamine vs sulfadiazine/pyramethamine maintenance for
toxoplasmic encephalitis.
Phase I study of recombinant human interferon gamma plus pyrimethamine and
sulfadiazine for toxoplasmic encephatitis.
Randomized, comparative study of rifampin, ciprofloxacin, clofazamine,
ethambutol with and without amikacin for the treament of disseminated M.A.I.
Itraconazole for acute disseminated histoplasmosis.
Foscarnet vs ganciclovir for CMV retinitis.
Pharmacokinetics of foscarnet.
Intravitreal ganciclovir for salvage therapy of CMV retinitis.

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