[Letter to unknown from Moises Agosto]

Dear Colleague,

This is the second mailing of antiretroviral therapy with protease inhibitors, a joint effort
of The Minority AIDS Council, Project Inform, AIDS Treatment Data Network, and Gay
Men's Health Crisis. This packet contains updated information about the use of protease
inhibitors in combination with nucleoside analogs.
Currently there are four protease inhibitors: Crixivan (indinavir), Invirase (saquinavir),
Norvir (ritonavir), and Nelfinavir (viracept), which are used in combination therapy with
five different nucleoside analogs: AZT, 3TC, d4T, ddC, ddl and with two non-nucleoside
reverse transcriptase inhibitors: Viramune (nevirapine) and Rescriptor (delavirdine). W.
do know that antiretroviral therapy with protease inhibitors is saving lives, but we still do
not know how to use these drugs most effectively. We do not yet know when is the best
time to start therapy, which combinations are best to use first, how long the effect of these
drugs can last, and what are the long-term side effects. Many people are working very
hard to answer all of these questions through continued clinical research, but this takes
time. Meanwhile, people with HIV are faced with having to make treatment decisions
today. Our organizations are collaborating in sending you this packet of treatment
information so that you and your doctor can make the best-informed decision about your
treatment.
We feel that the information we are providing you is very important and we are
committed to doing everything we can to keep you informed. We encourage you to
please make as many copies of this packet as you need. If you have any suggestions or
comments on this packet, please call any of our organizations. Thank you for your
support.
Yours truly,
Moises Agosto-National Minority AIDS Council
Pablo Colon-Gay Men's Health Crisis
Martin Delaney-Project Inform
Ken Fornataro-AIDS Treatment Data Network
5571095.0291.005