Recommendations of the U.S. Public Health Service Task Force on the Use of Zidovudine to Reduce Perinatal Transmission of Human Immuno deficiency Virus

MMWR

August 5, 1994

Executive Committee and
U.S. Public Health Service Task Force
On June 6, 1994, the U.S. Public Health Service convened a workshop in Bethesda,
Maryland, to develop recommendations for the use of zidovudine to reduce the risk
for perinatal transmission of human immunodeficiency virus (HIV). The recent results
of AIDS Clinical Trials Group Protocol 076, a controlled clinical trial sponsored by the
National Institutes of Health in collaboration with the National Institute of Health and
Medical Research and the National Agency of Research on AIDS in France, indicate
that zidovudine administered to a selected group of HIV-infected women and their
infants can reduce the risk for perinatal transmission of HIV by approximately twothirds. The implications of these results for use of zidovudine in HIV-infected pregnant
women and neonates were discussed at the workshop. The following persons participated in the workshop and either served as the Executive Committee writing group
that developed the recommendations or were members of the U.S. Public Health
Service Task Force on the Use of Zidovudine to Reduce Perinatal HIV Transmission.
Executive Committee

Howard L. Minkoff, M.D. (co-chair)
State University of New York
Brooklyn, NY
Arlene D. Bardeguez, M.D.
New Jersey Medical School
Newark, NJ
Yvonne J. Bryson, M.D.
University of California at Los Angeles
Los Angeles, CA
Isaac Delke, M.D.
University of Florida College of
Medicine
Jacksonville, FL
Clemente Diaz, M.D.
University of Puerto Rico
School of Medicine
San Juan, PR
Joep M.A. Lange, M.D.
World Health Organization
Geneva, Switzerland
Michael K. Lindsay, M.D., M.P.H.
Emory University
Atlanta, GA

Wade Parks, M.D. (co-chair)
New York University School of
Medicine
New York, NY
Paul Meier, Ph.D.
Columbia University
New York, NY
Angus Nicoll, M.D.
Communicable Disease Surveillance
Centre
London, England
Mary J. O'Sullivan, M.D.
University of Miami
Miami, FL
Sallie M. Perryman
New York State Department of Health
New York, NY
Gwendolyn B. Scott, M.D.
University of Miami School of Medicine
Miami, FL
Diane W. Wara, M.D.
University of California at
San Francisco
San Francisco, CA