Department of Health and Human Services Public Health Service, Grant Application

GG Principal Investigator/Program Director (Last, first4 middle): Duesberg, Peter H.
Name *Peter H. Duesberg Active Pendng X None
a Source and identifying no. National Institutes of Health 5 R35 CA39915 P.I. Peter H. Duesberg
Title Retroviral Onc Genes and Cellular Proto Onc Genes (supplement)
b. Your role on project Principal Investigator % Effort 5%
c. Dates and costs of entire project 09/01/93 - 12/31/93 $ 22,425 total costs
d Dates and costs of current year 09/01/93 - 12/31/93 $ 22,425 total costs
e. Specific aims of project Determination of the structural and functional relationship between retroviral oncogenes
and cellular proto-oncogenes. Are mutated cellular proto-oncogenes carcinogenic?
f. Describe scientific and budgetary overlap None: award periods would not overlap
g. Describe adjustments you will make if the present application is funded (budget, % effort, aims, etc.) None
Name Ruhong Li Active X Perdng None
a Source and identifying no. Council for Tobacco Research -- USA, Inc. #3057 P.I. Peter H. Duesberg
Title Retroviral Onc Genes and Cellular Proto Onc Genes
b. Your role on project Postdoctoral Researcher % Effort 50%
c. Dates and costs of entire project 07/01/93 - 06/30/96 $ 208,695 total costs
d Dates and costs of current year 07/01/93 - 06/30/94 $ 69,565 total costs
e. Specific aims of project Structural and functional relationships between retroviral oncogenes and correspondina
cellular proto-oncogenes: Are mutated ("activated") proto-oncogenes carcinogenic? Generation of retroviral
oncogenes from proto-oncogenes and non-oncogenic retroviruses.
t Describe scientific and budgetary overlap Scientifically, the CTR and the interim NIH explore different aspects of the
same general topic. For instance, viral transduction of proto-onc gene-sequences and functional tests of mutated
proto-onc genes. There is no scientific overlap between them and the present application.
g. Describe adjustments you will make if the present application is funded (budget, % effort, aims, etc.) Should the present application be
funded, Ruhong Li's effort on the CTR would be reduced to 0%, and we would hire a replacement postdoctoral
on the CTR at 50% to perform the duties originally designated for him.

PH_98(ev i9)(or agJ) ae A9O

PHS 398 (Rev. 9,91)

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