Morbidity and Mortality Weekly Report Vol. 41, no. 36

Vol. 41 / No. 36 MMWR 681 Vol. 41 / No. 36 MMWR 681 Seroconversion to SIV - Continued The frequency of exposures in SIV research laboratories and the risk of seroconversion in SIV laboratory and animal-care workers have not been well defined. Approximately 200-300 persons are working with these agents in U.S. laboratories. CDC has investigated two other persons with percutaneous exposures involving cuts with scalpels during necropsies on SIV-infected animals. Neither have shown any evidence of seroconversion up to 6 months after the incidents. CDC, in collaboration with the National Institutes of Health, is conducting a serosurvey of workers in federally funded SIV research facilities to estimate the prevalence of such seroreactivity in persons with potential exposure to SIV. References 1. Letvin NL. Animal models for AIDS. Immunol Today 1990;11:322-6. 2. CDC. Guidelines to prevent simian immunodeficiency virus infection in laboratory workers and animal handlers. MMWR 1988;37:693-4,699-704. 3. Khabbaz RF, Rowe T, Murphey-Corb M, et al. Simian immunodeficiency virus needlestick accident in a laboratory worker. Lancet 1992;340:271-3. 4. Villinger F, Powell JD, Jehuda-Cohen T, et al. Detection of occult simian immunodeficiency virus SlVsmm infection in asymptomatic seronegative nonhuman primates and evidence for variation in SIV gag sequence between in vivo- and in vitro-propagated virus. J Virol 1991;65:1855-62. 5. Allan JS, Short M, Taylor ME, et al. Species-specific diversity among simian immunodeficiency viruses from African green monkeys. J Virol 1991;65:2816-28. 6. Daniel MD, Letvin NL, King NW, et al. Isolation of T-cell tropic HTLV-ill-like retrovirus from macaques. Science 1985;228:1201-4. 7. Fultz PN, McClure HM, Anderson DC, Swenson RB, Anand R, Srinivasan A. Isolation of T-lymphotropic retrovirus from naturally infected sooty monkeys (Cercocebusatys). Proc Nati Acad Sci USA 1986;83:6286-90. 8. Hirsch VM, Zack PM, Vogel AP, Johnson PR. Simian immunodeficiency virus infection of macaques: end-stage disease is characterized by widespread distribution of proviral DNA in tissues. J Infect Dis 1988;163:976-88. 9. Gao F, Yue L, White AT, et al. Human infection by genetically diverse SIVsm-related HIV-2 in West Africa. Nature 1992;358:495-9. 10. CDC. 1988 Agent summary statement for human immunodeficiency virus and report on laboratory-acquired infection with human immunodeficiency virus. MMWR 1988;37(S-4).

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Title
Morbidity and Mortality Weekly Report Vol. 41, no. 36
Author
Centers for Disease Control and Prevention (U.S.)
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Page 681
Publication
1992-09-11
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newsletters
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newsletters

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"Morbidity and Mortality Weekly Report Vol. 41, no. 36." In the digital collection Jon Cohen AIDS Research Collection. https://name.umdl.umich.edu/5571095.0245.015. University of Michigan Library Digital Collections. Accessed May 11, 2025.
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