CCR5 Ligands in HIV Vaccines

subject C3 PHA3
A 308 41935

A
B
B
C
C

702
8190
3217
197
101

42829
54889
59122
116534
96532

C6
344
479
10707
9670
235
593

391 531
1467 561
13177 11158
11104 '8349
167 143
439 137

585
509
3398
9606
21053
22479

1.09 66.35 0.398 0.236
0.677 64.42 0.044 0.195
29.35 93.24 15.75 26.21
33' 83.67 13.72 20.69
0.134 64.7 0.041 0.129
0.114 75.55 0.122 0.09

HIV6 P246 CAND6 MIPAC3 MIPAPHA MIPAC6 MIPAHIV MIPAP24 MIPACAND

0.204
0
13
14.83
0.036
0.038

1.21
4.32
28.8
28.15
5.84
8.48

MIPBC3 MIPBPHA MIPBC6
1.18 69.86 0.54
0.854 71.33 0.521
20 41.9 14.1
19.24 42.75 10.45
0.038 10 0
0.034 17.11 0.021

MIPBHIV MIPBP24 MIPBCAND
0.604 0.341 1.88
0.631 0.224 1.69
13.8 11.64 11.4
11.58 9 12.81
0.018 0 6.69
0 0 5.35

RANTC3
2.44
1.92
2.8
4.41
1.76
2.28

RANTPHA RANTC6 RANTHIV
34.59 0.934 0.396
36.55 0.311 0.415
12 1.37 1.56
28.5 3.12 2.8
6.75 0.868 0.737
13 1.52 0.856

RANTP24 RANTCAND
0.624 3.09
0.655 3.07
1.35 2.67
2.6 6.89
0.905 2.62
1.38 4.62

Table 1. Comparison of production of chemokine production and proliferations indices in cells from three
subjects at different time points. Proliferation: C3= control day 3.;C6=control Day 6; PHA3= PHA stimulation
at day 3 HW6= whole HIV day 6; P246= p24 antigen day 6; CAND6= candida antigen day 6. Chemokines:
MIPA= MIP-lo; MIPB=MIP-113; RANT= RANTES. Stimuli designation and days of incubation are the same
as above.