CCR5 Ligands in HIV Vaccines

clinical phenotypes, defined racial backgrounds, and quantified risk. Mol Med 1997;3:23-36.AGD20. Quillent C, Oberlin E, Braun J, Rousset D, Gonzalez-Canali G, Metais P, Montagnier L, Virelizier JL, Arenzana-Seisdedos F, Beretta A. HIV-1 -resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene. Lancet 1998 351:14-18. 36. Schols D, Proost P, Struyf S, Wuyts A, De Meester I, Scharpe S, Van Damme J, De Clercq E. CD26-processed RANTES(3-68), but not intact RANTES, has potent antiHIV-1 activity. Antiviral Res. 1998 39:175-187. 37. Oravecz T, Pall M, Roderiquez G, Gorrell MD, Ditto M, Nguyen NY, Boykins R, Unsworth E, Norcross MA: Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV (CD26)-mediated cleavage. J Exp Med 186:1865-1872, 1997 38. Struyf S, De Meester I, Scharpe S, Lenaerts JP, Menten P, Wang JM, Proost P, Van Damme J: Natural truncation of RANTES abolishes signaling through the CC chemokine receptors CCR1 and CCR3, impairs its chemotactic potency and generates a CC chemokine inhibitor. Eur J Immunol 28:1262-1271, 1998 39. Proost P, De Meester I, Schols D, Struyf S, Lambeir AM, Wuyts A, Opdenakker G, De Clercq E, Scharpe S, Van Damme J: Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection. J Biol Chem 273:7222-7227, 1998. 40. Nibbs RJ, Yang J, Landau NR, Mao JH, Graham GJ: LD78beta, a non-allelic variant of human MIP-1 alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity. J Biol Chem, 274:17478-17483, 1999 41. Menten P, Struyf S, Schutyser E, Wuyts A, De Clercq E, Schols D, Proost P, Van Damme J. The LD78beta isoform of MIP-lalpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine. J Clin Invest. 1999 104:R1-R5. 42. Xin X, Shioda T, Kato A, Liu H, Sakai Y, Nagai Y. Enhanced anti-HIV-1 activity of CC-chemokine LD78beta, a non-allelic variant of MIP-lalpha/LD78alpha. FEBS Lett. 1999 457:219-222. 43. Aquaro S, Menten P, Struyf S, Proost P, Van Damme J, De Clercq E, Schols D. The ld78beta isoform of mip-lalpha is the most potent cc-chemokine in inhibiting ccr5 -dependent human immunodeficiency virus type 1 replication in human macrophages. J Virol. 2001 75:4402-4406. 44A NakaoMyomiyam -Shi-ada-K--trueM-s--huma-gene-g-a-g for cytokine LD78 and their expression. Mol Cell Biol. 1990 Jul; 10(7):3646-58 45. Garzino-Demo A, Gallo RC, Arya SK: Human immunodeficiency virus type 2 (HIV-2): packaging sigual and associated negative regulatory element. Hum Gene Ther 6:177-184, 1995. 46. Doherty PJ, Huesca-Contreras M, Dosch HM, Pan 5: Rapid amplification of complementary DNA from small amounts of unfractionated RNA. Anal Biochem 177:7-10, 1989. 13

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CCR5 Ligands in HIV Vaccines
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Garzino-Demo, Alfredo
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"CCR5 Ligands in HIV Vaccines." In the digital collection Jon Cohen AIDS Research Collection. https://name.umdl.umich.edu/5571095.0230.031. University of Michigan Library Digital Collections. Accessed May 11, 2025.
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