HIV-Inhibiting Chemokines: Critical Host Factors in AIDS

SUSAN F. PLAEGER, PH.D. SUMMARY STATEMENT
301-402-9444 (Privileged Communication)
[email protected]
Application Number: 1 RO1 AI48384-01A1
AARR-2
Review Group: AIDS & RELATED RESEARCH 2 AIDS - EXP
Meeting Dates: IRG: JUNE 2000 COUNCIL: SEPT/OCT 2000 A26
Requested Start Date: 12/01/2000
PA98-091
GARZINO-DEMO, ALFREDO, PHD
UNIV OF MARYLAND BIOTECH INST
INST OF HUMAN VIROLOGY
725 WEST LOMBARD STREET
BALTIMORE, MD 21201
Project Title: HIV-INHIBITING CHEMOKINES: CRITICAL HOST FACTORS IN AIDS.IRG Action: **
Human Subjects: 30-HS INV-NO IRG CONCERNS/COMMENTS
Animal Subjects: 10-NO LIVE VERTEBRATE ANIMALS INVOLVED
PROJECT DIRECT COSTS
YEAR REQUESTED
01A. 200,000
02 200,000
03 200,000
04 200,000
05 200,000
TOTAL 1,000,000
NOTE TO APPLICANT FOLLOWS SUMMARY STATEMENT.
CRITIQUE 1:
Significance: This is a resubmitted application from a new investigator which
was first reviewed in Feb/Mar 2000 and returned without a score for amendment.
This and the earlier application propose a longitudinal study (using the
Baltimore MACS cohort) on the effect of beta-chemokines on HIV disease
progression. Given our current understanding of beta-chemokines and HIV
coreceptor usage (significant parts of which were taught to us by the
Investigator), such a longitudinal study is important in the sense that it
might illuminate the effect that beta-chemokines can have on HIV disease
progression and shftsin vihra1 phenotype-n--v-ivo. in-so-doing, data-from s-ucha study might also provide insights about the composition and timing of
therapeutic strategies using beta-chemokines in HIV disease.
In the previous review of this application, concerns were raised in the
following areas: (a) that the Preliminary Data did not clearly show a

definitive correlation between beta-chemokine production and HIV infection; (b)
that it may be difficult to interpret data about "disease progression" in the
setting of HAART (currently administered to many if not all of the prospective
subjects to be evaluated longitudinally); (c) that it would be useful to study
Date released: 08/01/00 Date Printed: 08/01/00