[Letter to Bernadine Healy from Jon Cohen]

TO: DR. HEALY
FROM: JON COHEN
October 9, 1992
Dear Dr. Healy,
As promised, here are data from the Walter Reed trial with the
gpl60 therapeutic vaccine that have yet to be published. These
are copies of slides that Redfield presented in Amsterdam. (He
gave me these and I believe because they were publicly presented
they are public record.) In essence, they show that vaccinees had
drops in their peripheral blood viral burden as compared to
patients in natural history studies. Though these results are far
from conclusive--there are no matched controls here, the sample
size is small, who knows what the error bars or assay validations
are, peripheral blood and lymph node viral loads can vary
greatly--I think they do deserve the label "promising." For many
in the field, in fact, I think this data is the most persuasive
yet presented that the therapy is having positive results
(positive CD4 data as published in the June 1991 New England
Journal and discussed repeatedly at public forums has swayed few
researchers because of the vagaries of CD4 counts).
I'm also faxing a copy of my article that comes out today.
I look forward to hearing from you.
Sincerely,
Jon Cohen
3445 17th St. NW
Washington, DC 20010
202-332-9564

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