Program Supplement [International Conference on AIDS (14th: 2002: Barcelona, Spain)]

f LBPP2211
The epidemiological status of IDU and HIV infection in addict
cases submitted to HIV/STI/IDU Counseling and Care Center
in Kermanshah province
Alaei, Kamiar Alaei, Arash, Mansoori, Davood, Namdari Tabar,
Hengameh, Motamedi Heravi, Mitra, Komasi, Ali, Rangbar,
Heshmatalah (Islamic Republic of Iran)
Introduction: The assessment of The Kind of drug abuse and
the pattern of use and history of prison is very important for
evaluation of trend of HIV in the future.
Methods: In this study volunteer addicts were evaluated and
IDUs were tested for HIV.
Results: Of 731 volunteer addicts, 731 were male (97.5%) &18
female. 2cases<15y(years), 18 cases between15-25Y,423 cases
(57.9%) between 25-40 y and 187cases (25.5%) >40 y with mean
34.6y.(14-72 y).335 cases (45.9%) were single,286 (39.1%)
married,87 (11.9%) divorced 19 (2.6%) widow and 4 unknown.
506 cases (69.2%) had history of prison, with mean 29.7
months(1-36omonths). The recent method of abuse in 222
cases(3o.4%) was smoking, 90 cases (12.3%) snuff,314
cases(43%)injection,45 cases(6.1%) oral, 39 cases (5.3%) not
use and 21 cases(2.9%) was unknown. 105 cases (14.4%) used
morphine,599 cases (76.4%) Heroin and 27 cases (9.2%) other
substances.429 cases (58.6%) had history of IDU and 302
individuals (41.3%) had needle sharing, the mean of injection
during was 12.8 y. (1-52 y).19.2% of tested cases had HIV
infection. The most common infected cases age group was 15-25
y. 25% were divorced &16.9%single. The chance of HIV infection
in previous prisoners was 2 folds specially in 5-10o years (34%)
residency. 30% of oral addicts with previous injection history
had HIV infection. The primary (31.2%) and illiterate (28%) cases
had the most exposure of HIV infection. 55% of addicts with age
beginning <15y were injecting and 20% had HIV infection,
compare to 12.5% >40 y were injecting and nonHIV infection.
Discussion: Injection form(56.8%)& Needle sharing(41.3%)in
addicts of our province is very high.The heroin using is very
common (76.4%) which can be abuse IV. Most of the addicts
have low level of knowledge and more than half of them
started addiction before 20 y,so education of young people
with low level of knowledge is very important for prevention of
HIV infection, key words: addiction-prison-H IV-IDU (see Table).
Corresponding author: Alaei, Arash & Kamiar, No.72, Sarab
Ganbar St., Islamic Republic of Iran, Tel: [phone],
Fax: [phone], Email: [email protected]

[ LBPP2212 I
Phase I clinical trial to evaluate the safety, tolerance and
acceptability of the invisible condomTM when applied
intravaginally to healthy female subjects
Trottier, SVIvie Omar, Rabeea, Desormeaux, Andre, Gagnon,
Marie-Therese, Vezina, Francine, Guilbert, Edith, Bergeron,
Michel (Canada)
Background: We have developed a topical microbicide gel
formulation containing sodium lauryl sulfate (SLS), called the
Invisible CondomTM that can provide both a physical and a
chemical barrier to prevent STDs including HIV/AIDS. We
showed that SLS is a potent inhibitor of various HIV and HSV
strains. We also showed that vaginal pretreatment of mice with
the gel containing SLS completely protected animals against
the lethal vaginal HSV-2 infection and that the gel was well
tolerated after repeated vaginal applications to rabbits.
Methods: We have conducted phase I clinical trial to evaluate
the safety & acceptability of the Invisible CondomTM when
applied vaginally once or twice daily for 14 days to healthy
female subjects and their male sexual partners, when
applicable. All 47 female subjects and 23 male sexual partners
completed product exposure. Women were divided into 3
groups: sexually abstinent, sexually active with tubal ligation,
and on oral contraceptive. An applicator specifically designed to
distribute the gel uniformly throughout the vagina and cervix
was used. Nugent score, pH, general & genital adverse events
were evaluated. Gynecologic and colposcopic examinations were
done at baseline and after the last gel application.
Results: The gel persisted 4 to 8 hours after its vaginal application.
Vaginal flora were not significantly altered as assessed by Nugent
score. The vaginal pH did not change over the product exposure
period (pH before, during and after gel applications ranged from
4.4 to 5.4). Minor symptoms (mild or moderate) possibly related to
the product use were observed in about one third of subjects. The
most common events were erythema, itching, burning sensation,
vaginal discharge and vaginal dryness. No genital ulceration or
lesions were seen during gel use.
Conclusion: Both the gel formulation and the applicator were
acceptable by most of the subjects. The Invisible CondomTM
was found to be generally well tolerated.
Corresponding author: Omar, Rabeea, Infectious Diseases
Research Center, CHUQ, CHUL, 2705 boul. Laurier, Ste-Foy,
Quebec, Canada GIV 4G2, Canada, Tel: [phone],
Fax: [phone], Email: [email protected]

Age of beginning addiction Number
<15 69
15-20 288
20-30 294
30-40 44
40-50 8
>50 5
unknown 23
Total 731

percent
9.3
39.2
40.21
6.oi
1.o8
0.67
3.1
o100

HIV+
9
27
20
o0
o0
o0
5
61

HIV35
136
126
13
3
5
12
327

incidence
20%
16.6%
13.8%
o0
0
o0
33.3%
15.7%

recent addiction IV%
55%
46%
41.8%
31.8%
12.5%
0
4
17.3%

smoking
20
78
94
21
5
4
0
222

not use
3
21
15
0
o0
o0
0
39

oral
2
16
22
3
1
1
0
45

snuff
6
39
38
6
1
o
0
90

HIV&addiction

HIV&prison

Residency
in prison
<1 years
1-2
2-5
5-10
>10
unknown
Total

number
268
60o
99
49
21
9
506

percent
52.9
11.8
19.5
9.7
4.3
1.8
o100

H IV+
17
9
18
11
2
5
62

H IV127
26
49
21
9
4
236

incidence %
11.8
25.7
27
34
18
50.5
20.8

Education level number
illiterate 51
primary 151
elementary 213
diploma 131
genious 15
licentiate 8
unknown 162
Total 731
HIV&education level

percent
7
21
29
17.9
2.05
1.1
22
100

HIV+
7
25
21
5
o0
o0
4
62

HIV18
55
95
61
10
7
77
322

incidence %
28
31.2
15.9
6.1
o
o
5
19.3

XIV International AIDS Conference BARCELONA - JULY 7-12

33