The Nairobi Declaration: An African Appeal for an HIV Vaccine

E. Principles:

The African Strategy for an HIV Vaccine will:
1. Include all countries in the African region (although not all countries in the region
will need to conduct vaccine trials, it is essential that all are fully informed and
supportive of the overall effort).
2. Be coordinated with other ongoing national and regional HIV prevention efforts,
and with the International Partnership Against AIDS in Africa (IPAA).
3. Serve as a transparent collaborative process, with equitable participation of
multiple partners from the public and private sectors, from countries in the region
and from the international community.
4. Be developed as a long-term and sustainable effort, based on capacity building.
5. Promote research with the utmost respect for human rights.
6. Aspire to the highest ethical and scientific standards.
7. Ensure full community participation.
8. Promote parallel development and evaluation of different candidate vaccines,
focusing on those deemed more appropriate for the region
9. Contribute to the development of HIV vaccines, consistent with the concept of an
international public good.
F. Strategic milestones:
The African Strategy for an HIV Vaccine will fast track HIV vaccine development
by advocating and working towards ensuring that by:
1. 2002 - Appropriate preventive candidate vaccines based on virus subtypes
prevalent in different regions in Africa are available.
2. 2003 - At least four Phase I/II (safety and immunogenicity) trials are completed.
3. 2004 - At least one Phase III (efficacy) trial is initiated.
4. 2006 - Specific plans to make a future HIV vaccine available in Africa are
developed.
5. 2007 - At least one Phase III trial is completed.
Promising candidate vaccines being developed and evaluated elsewhere could be
considered for adaptation to African subtypes, especially after successful completion
of efficacy trials. Fast-tracking such candidate vaccines could reduce the timeframe
described above.
G. Activities Framework:
To achieve the above strategic milestones a number of activities will be implemented
in the following areas (as defined by the WHO-UNAIDS Global HIV Vaccine
Strategy):
1. Advocacy, Information and Education:
* Adopt a multisectorial approach, targeting national, regional and international
stakeholders, in both the public and private sectors, including international
organisations and bilateral donor agencies and countries.