Abstracts Vol. 1 [International Conference on AIDS (11th: 1996: Vancouver, Canada)]

Track C: Epidemiology and Public Health
Methods: We analyzed trends i PA-AIDS cassrepor ted through
ed fo rieprting delaty tedctoes rego:ted with ot riskk Icevatluat
ohorto, ADS so:rveiltne dti wetre modleled usirg'Wing pi ored,
inuaior d itibution aridrepoiiting delaty ResuIitsifrnmifhe Sui ye,
AV~n ittn IICW fi n /18) to 914 were(u0e0to calule(rn e.t,
n~rt(-Iy)with PA-AI[)S, Fy thu i r f rigneteirssof Alf
a mo dec]d teveloping AIDSrin!,,Ity:flfe (2 1()madi:n
f1in ~n 26 % fogxected ro. of iftrts wth PA-AIDS wes rrnp
AIDS incdeneryI fifhyi
Results: I hr igh Septenmlet 199i)94 A AILDS aiweweie 3 igp
'46i:199, 9a in r 93'andt 67 ir 199,1Theto f PAAIDSrci
ho was -0 / essi t 9(N --158) tht: it:I I:941(2141 ard 2r,
with mreurnn. rss00dii in eaoh qti of 191, declires inI t 35 err
yri(38~6it.nI Syrs (10%),itut nochilhren drat 6-l2 yrs
expected ino of infruts with PA-AIDS red rru SLBWuf moireled ft
ohuItintially less, gartirclarly her rhildier forr in 1993 arid 1994.

Tu.C.2594 - Tu.C.2598

td u t t r t:ir pro tls giohihit invaiv oe u:iteoi rig nudscalp sin p1ng forpH inorde: to
I)irthi 1 tat: ze fel exg ore trtmater nil blood and secretioirro Sirice 4/ I /91, we ether ed the
O Ic r-T (I7( rei /tofr ht egii tom ni r ip:t ton, itud neeinttal ZDIV to iii patients.Onl ry
I/1 7 womue: iefousedIZDV hor in acreptanre rato of 74I I I 'uer'a te oh getrinatil tr ansnri
Siu.) hf i ioh efr e 4/ it vi, as14.8%;(7/16) whileithetrateuhf t it rsor sot iuinr'the ACA 3D
endby Oi tg::etofhZI 2Vimprutoed to S.) /I!7)(fuR-fI.f18p.g0fIC.There wso i rtrelit
iO rte t onof set g iI o in thre tuants with nmte rual f3'I rr its to' fi 0ruutu (u/h),200-,deled S tt n 3hI '1 2),Sfhdtuun14.3% I 7).T ete waonrsgnifirtdhfferne it:U it
tu on nit ordeof deioery. CesarearsCcin mithe-27"'(3111);ni elovery
99): rtito ""Y ift eewis otu orrelaiontwith lergth of labor, ho:airon ofrt:urueh ueu
tyr of', o itor nfhr of seitnd ite.
pt ed Conclusion l hr I uopulatier:, ZDV ard crefuli ott parbtum irragenuent his Shad a yrnii
i:I sx it rirt i:ir inI:: Jr vsit perinatal HIVS transmison. The NY/- MC tpproach toi:rtegr it
Iwith the Ott:ai o 7 r t'Ot. it r i cre ovith urcii/ittyanduedhiitr icre enrorages high corpliarnce
It t t +cr awas yrith: prerratat isitud nay bereogentsile for our high irreptanoe raite nhof3V. For ther
stuihes' h Iud cotetanue to assess thue effectiveness of ZLDV rn clintical prairtice.

Isf.' ted (Li3e/or SCIhW'tO iamodiel)
I ri tO d AlIS r le e Wiry Mudel
Il it ~enc (')

he itoh liii th oh Int
2Sf If1 u20 I31
260 291 021 01
/ 'i,, +,

lita ion rraterna l D toue itnd PCfP g: ghiylto ire truromurlete;
inc ideriro huy bithtIyeair lot inhfants rhuatgodIlittle ho: birth crhhtst
Conclusions: PA-AIDS icide:nor ipgear-, to Ito derreastry in the Il
exelairu thisdeclite.:to ter'nal/nuoriatal ZDV is erdelay i sr ur ss
inreasisnggPpr ogpuylaxis indI tere:iutic rite:rvertt iricas
AlIS ciseitnd decreatc,,it theseno o hldrernhuor to IV neeI
frin nalsis).Pedi at:chIlV AIDS oarvye itncehis been revid od
inorto itr iH/IV testing? if itothersn ter iu Ineer it t ZDV u,
li:, t hIV exgoool ch id:en to ivutaitthe uipat of USPHS g
it PA AIDS rises.
Mi: yL u ii ndegrer, CDf, h00lfChtnRoil, MS F '17 Atit sif,-txttlt t 6ue-2029, entain'. MLItu aCIfIHIV It FM t DFit

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Tu.C.2594
FACTORS INFLUENCING ACCEPTANCE AND ADHERENCE TC) ZIDOVUDINE
TREATMENT TO PREVENT VERTICAL TRANSMISSION OF HIV
Si':., LBriaF Flennessey, M Y -,Sowrell.1 R.'U CfAtlinti f~ 1
Ofriver ity, Atlantt, GA DSA; *"DUivtersty of Soith C itolina, Ccl,
Objective: toeidernthfy hi to: asoertted owith DIV efe ted wormen' r().ti
riea tel sd d/ten'to ordovutitre ZVD) treatinont rtevCotvex t u
Methods: We so:rveyed 181 HIVO weouenrppritcpatiny in a la:rgor it ' i
frpig'. Patrticpintos'were pimliirily Afrucan Americat (84iI ted r 'h;,.s nIi i i
itt go oh f.Pgrttiitunts rrac/ two d ffer erit scenaicivabouittthe v V ol eofrdadidctdterwlirns oacp tt t lrl,:1,;I oa
the l':ikeihrood/ 0f f: roin itrent u on taeoif 0 tot If f/The ' ' ', t l: cce
1the secunitios wore 1I trmeof init ipieot ronutairt (Ited I12 it ' r io
litegnanit, ani / rlibo: 1:2) otfectivenes if treaitmueo 1 hrfrom ~') t() ', I t
en'erteygruenso/ot the nothe:rtnd bby (/ffer ig: nmbertoftir t 'i tic ici
get hay); '1 siue effects for the tuoth etrrnd baiby (sume vetsus r ':' 1 h) rtooe towaitd treaitmlertnt Uorug iuportvetss oeedouts). Dr:>, I /, VI
experienc.e, ted scenaio ceuditiuns wetr':ucluded imulltIle Fr;ei-,:
Results: Sxty fhoe ue:rent of the womne 'itoited -t sortechf70 c: ' ' f~ ri ' I U
fcr: acceputatnce nd idhuere'nce te ZVD treaitmnut:eruly1Sid:5:1't (r t )I0Iorower For senr ioitn/rhich doctors "Id soureedoubt'' hbost tri i'r '''I'reorIc/up
poi: uuitd idhetr0e0nerlined.r/Livtng totito r/I itarea inc h Svir,",I iSi t'fig / t C I
iciat ito:irn/d/ctdereewheteais pt tecpe:ru ncttZVD i r t ' ' I sl
eft/f tooretatednterest in tictr ont by almostI30lpoits.
Conclusions: These tresults cygestthtI 0moetIwoeen a isk rIr ur i. ii! r
in irttetsto7VLD tieatmeCt. Prtcpion tinVDI treatmtOuti iti, ', ~
attitudos,ito hde:r rng the imrta ce: 00fcummunecat:onrou pu ' i. 1 10u
paie nto. Woenerviol:giit ot ubrr tr eu, ftavirg topatthftto:ry 7of t
i AIDS nmay reed rrotereassturanoe 0bcit the efficroy of/ZVt rnaF el DC10 lfo od aitpE4 ta tCih>
6396 614/3 FAX: "304 6f9-19 88 E-miitifFS3ref IDHIV 1FM CDt rit?
Tu.C.2595
THE IMPACT OF ZIDOVUDINE ON THE REDUCTION OF PERINATAL
TRANSMISSION IN NYC PARTURIENTS
bit d be: or Fller. McOuiinn'ess K, BRyger SDT/ueNew Yorh/[-I ~ ',lot
Ceten, New York, DSA
Objectives: Toevluatte hrtrpict of DS Public Helth cc':vi o, ''Did
I iur'JZLV) 0'use iothie pit ittaI trat nmiionrar t" uf IIV it:a it t!y _ (' ',se
at dsIcribo the mtieuhofcate provv/edtordito ti n7it t _r
Methods' A 'tiedr/idized/ itrt ue:nt wasusd or v0aoaotite' I D f Ii r:rHCCfo /19 23/5.Vralsaaye nldd; D
count s, ZDIV iso, o tI If IaIr; do:atiou of rutuired trernruho: it: i ' ~ e
stiyeof/ lbitSt' tirlysiswas erormredo tgI ycri rire to'et
sait ic ignf0catOO
Results:VVne orc rre/oto ti atAID1 in RpouIstove H/ie
n tit ohf HIV- otisttus. flI3 a i itdeicveredfdtty'ng;.I/IV
of ihr'renae wis ivi'e'o 3 mtr infat iitE,"of/L. w t
/HIV stitus prorto pregnttnco andI3It,we I greed tIih ' i' i _o
ntetitng 0/riogam.Paitetti e refer red frot rciourit 0)8nicdir,, i,dintr
rik centers.Linkag ry e too'eri o /r each wom nwitts D rt-hait t t 1. i ctl '500e
it tnordr oassurerrninigiprimaryt r h orthi/twomn ndto I fy I:: Y~r.1

Fllecj. (It: lI "tert MD,FThe New York Hoespital-iornell Medical Center 525 F. 68th Street,
94 f tv, ':<_ NFI ) 1212-7'4f-1164 212-74h 8/h? (Fix) e rrnd hrnrirtI.redrernelc'hi
>4 Tu.C.2596
53 AGE AT FIRST POSITIVE HIV- I CULTURE IN PERINATALLY INFECTED INFANTS:
18% IMPLICATIONS FOR DETERMINING THE ROLES OF INTRAUTERINE AND
C INTRAPARTUM TRANSMISSION
/ r ~, -I I __' Or'I' ':J, Her 'hw R lellinger 8, Lancheon in S. bernJFPatanso MMoye J(fist
ther' W inn': /l it tnt FTraonmustern Study (WITS).t Flew Eyglamed ResetorchIn ostituites,
er > ~ )ito: ' 'a l fIt. Iitt:ion ml Institutes ohfI/ieith. Bethresdar MD, LISA
orFA Objectives, ito,,i i rti r: OCeI no iti tiiteoUr'ited Staitosperin ital cht.itI t
ii idth'' i,'blily I t:nHItV I cmture of peripheral hlood woil egposiyie flrtthe
pdc I firs nc. a,'' i/yof lifo'ifcoltreswer-e pe/5 rood dily' rid ()to '0 ssthe roles oh
xi 'trnt i oc III t ' rd r inapu tel IP) tramensmissionrs (FR).
oIs Methods Inc,,twas hetrered by tepresence oh twogsirtiye go:ripheral 0blo0dh 00
t~ae. tr_ 01,wi y hosdefinonre. infutsuhald(0itive coltuires.Altheough the ige at ohirot
IiJ!1ire a irfirst bo potiveiso t knoewne xactly itt any particulaitftoh,. t ittanbe
2051; I itar. eIc' i ter oi-vl betweeo the list negatiae culture ted the ftrst positive'ciltureC(it.
if he i-, cut _ f to ositivebetween' /irth ent the is' poitiv~e oulue).No~n-pamtric~'.
to r I oif fc, ' ': ml::?the distributioni oh timte to oeernt hrointrrervoil ceeso:01 drtm witr'
Results. LI ' r avatoirlmble hreorn atI34III lV- I peoreimI ay iteeted infirts fir etweeni
ii: 'try I'K)<l1 " I Spr il 99S whe were oleid in the WITS. The e itated prebblri
or i( }2 I tpoeitiov'ocslturetby Imys0, 2, 4.,lard 30daysof hie or-e 2/.,'%(t61,'
1 a r4 I0 'I0.0,10(+2.1,.1 7.9;x(:~22.5) (88.7n i(t7.S ( urod 89.2O(~7.1 %,ropertvi ticliyt t 'huttwithooutatesobirredernday 0eor-I of ltfethe proportions wthupst
f-HIV: o e,t ar - II % 1/7)od 17,'' 4/23), oespectioeoy
Conclusions It hi been suggestel thait.a pesise uliture duirng the first 48 houit oh life i
'edl-:indicatve:. i tIS 1 Ire 26% probfii1y of ill'ositar'ciulture clotiny the ftrs1 few o/mys oh hie
oh,nthesc daaI;it i i sistortith tie hypiothesistha t IPRiuuilly ecour dirg ire IP perirod.
tech I it 'o ' anil r I (i t or s loting the litter pit Iohthue hr st weeko rnake it diffirult te sperthya
I in cuiit[5 t t " 'cirtwo firila tieno tD vs. IP1 1) altheoigh by dry 9 neaitly mll fected/
reth i i nt st ii lI i tble te produce t pitaive oultur e. Dltierately nor e dcentive dehinititn
-ett ianI iao~t sr y'l:<eoh eeth ods for- distiygis/i ny betwe'en H modIP FR aweIlIse needed.
Ie (-,troe /. r,15im a. FnglamReIsPt-rch Instittes,9 GaenStreet, Watetoan, MA 0 7
I-at- Vr0 ir t 11/x250tFaxo. 0 7)')'682,16f(rtirnil: le 6 tiotiatti nloil i
0 0) Tu.C.2597
EFFECT OF MATERNAL VIRAL LOAD ON PERINATAL TRANSMISSION
2 cac A. eaJ,10I ustin L. Rother 0.. RtsI cod SChame I. LosA:ngele 6'uityIversity o
Objective: 1 io' mte:,~~aiofvrl odwith gotremt - I trainmi'stoo.
Methods: I- UIlls fitiiinat.s ii ha''i beriprospectivlyenoll. i tot!ice -miln
'a oI'ain' /IaIdtlood wis eole tellfor HIVculture, Pal. ICD P21 itnI H/IV Pt-A i-vt'1;
Ri c a gpi ted betweer f-12 hours sirng -t:ndird FHO) I-LYPAQDI
is 0 rfs t.I ll RNA leoos were Irterruiraed tigh AB oh ~
ili ic A-rft iwn ilso teste'd usingRNA PrR RDCHL(.
Results: F0 i!f met 'with known outcoerne.21 were HtV rr'fected/and 96 were eot.tRNA
lei 'ick neernttred it Iisti:rrmoster on in deliver:y for 18 enethors.fGtomuetio near
1111 PRAA lvelsare lhighercotenm itters (-'thnifoinln roenrnseite:s (N-T's)(22,596
cisu i 1 3 in rs/nrf. p (1-.25). Horwevaer there ris0overlain i:RNA IcvelsIbetween the 1's
it i the' N I 26" of T's vons0s514 ohfIlT's hid RNA levels yreotter thin 1011100
It.2L' it a/d3 ef T's vetsus 28% oh NF'shid RNA leve'ls essifirn 11.000(p=.758)l T'e
or t t t ott h,,-,ne. of RNA wts net ais ociated wIthtrn smissioe (p=.06). Irnta]tmtl tm
iiit i ay ' osbset oh 5)9tinthirs, piresene o f iefectious vi:ris. plasmam on::trd P24
Ial t ir n ' I ee _uird teeassoeirued itiStraesmison(p=.022,Ip.011) CII P21 wis cot
ltildto eho itodwith trmismonei(p=.662).
Ldou Conclusion: NotiCnIii:ramute:r con idequaitelypiedici vetrtilinransnmissino of I IIV.T iv.
to: ce ii ci 'ed ti iatn c1ithiLdeorud noteo these with Sigh RNA levels wonuddrnit rcapture tll
a':o t n IJ
od it Andra oi l i Fl [D.1912/ Zenal Avenue, Cab0B Ie.s ArnyrlesCA 901113ISA.Tef I21)
-E0(-'8 ' [ I! 3)2f-8162.:eemtail:iovrose )Ii us~edit
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I U.C.25Y8
DESIGN AND DEMOGRAPHIC, IMMUNOLOGICAND CLINICAL PROFILE IN THE
TRIAL OF VITAMINS IN HIV INFECTION,TANZANIA
fi, '. O.'h/rt t ID, SI ' eno' nan tDl.'M inn o in 'IMw ui r'i' FS M ~rifhI.,
hi:,n~ ( tI ira-d cieol of PtblricD lunniB ostoMA USAMui n r Unv.L llege If
Ili S r t;c I in 'cshSlamtr,Tirzuruir
Objectives: 11!.r: nut tent suppleent tion nitainbe innimportait innsciitl it 01htyl tot i d
tio' tmit i lyle: forltV ser ge ot osepec illy those irudeoct og otri 'A few
c~srvion: i i tics i/nit extrneelisquostioo exis.We ire orpienrtree.it itradomied