Abstracts Vol. 1 [International Conference on AIDS (11th: 1996: Vancouver, Canada)]

Tu.B.541 - Tu.C.121

Tuesday, July 9, 1996

Tu.B.541
QUALITY OF LIFE OF GAY MEN LIVING IN THE HIV SPECTRUM: INTEGRATING
ILLNESS EXPERIENCE WITH THE LIFE STORY
Blooro F C enter for AIDS Intrveotion Rosent ch (1 AIR1,1Medri al ('2: ~f\ I cn 0n,
Depir tweet ot Psychiatr y aodtBehavioral1Medi cine, NdMi n ri e, AWrscorin15!S.r
Objective: To crier stand Ihow'a sample tfsiayoe irving II iifro t:' c l~rtO n
work, to proserve or improve thre qua lity ofthe iivs
Methods: fthnograiphir ob~seti tosanIrdelpthrlife story irnterr ews.ss isobtairedIfronm
twernt/ Anglo-Ameicain p p men attenrirng in HIV li ric. A mearoirg-cererdI' antihiropological appr oachwars sed to oni lyze datiahryJrdrntifyingcrpornt oilondric ain t rtpsychocultural themes presented inliteostoryinarsrives. rI her i Pi'nais.vsrihancd i denti
fyirog idditional asportsof life story nrrntivrssuch sb styiicr rintatiorn,o
apprrsarchiiiplife after draprssrs is'1 IV1\/nfectio. Fhcres, tlers 'Iid othels( i lct of tte
life storyp we:re exainred to:r irplicit anrd evl icit refroenrcc to pe reptirons ifdlit! of life.
Results: Analysif tie daia resulted in irintiriction ot thou: s. fur l:d:Is) orserrroming obsstrcles irndt onirorng phaiirdships,2) reioc~ity irk I iIp::ii Irincainup foiothe:s,3)a
heightened ivwirenessrod arerialiar: ot ifeis a airect is' it ot Lciis vsIll / Ri stier,
and '1) oraintairingipa life tIhat is a:neventtul, tstbe andost e i ti rll, unchainped desite infectior
witshHIV. farh hIlemre deiesir'syi sti cr ien:aion: i approaci np lf ter e r in rsto e
I lIV,perti rt: r.I ifestory pasriesseridr) aeto I: t thes'dercofnitsch I:rnyvi 51 iulisralat
meeciated eapectations of the liteo i seviis ivoitaifac torafctigpc':idctqisoitpy o e
Conclusions: Re:reiord rqualty oflilfr'.(i50iven mean50g throug1 tIeCir tet oa ntfrtais
expressed throcugt:nraiiisofat her ic0or:: I ~ pIsl rheie r it. rid hituis 5xpicrtations.
sNar ratiovssist these lifto tries revealsowrithIe'miini p riti 1 ipin th:i resirIhOsvslouto
and work to tarservsoor iits:rcvi'tfhepiulity/ofsthetiir lives Shtdysir tiripantisc-s ii::vie too::
qua lily of life irn terms Of t[isynchrIonii5of rvrydaypsifeI i::)ents trrs vtprineitilscultiii
allp coed:itt e xta5tirori',crrilt::: ivalIs, 1 ms 0tyle',vinI oilhsr fcti 5 I tfe Its'
stor, Tisose mn orkatoI inrt HI ePa:1e Isemis and:) crI' neino then' roigoirag
ife sto:rp as aresir rofmirsnutaIi i rts:r im ripg their: aityCosIlite.
FroeerckR. BloorrrPh.D.,12,19 Nt Frair his 'I i Itl irs'. v, A/i sii:5320r2,IISA,
Telephtone.:'114-PP65tt820, tie- 1114- 765 8823t, c-rs I. ft a~cit i a: r eIs
Tu.B.542
EFFECTS OF COMBINATION THERAPY WITH SAQUINAVIR, ZIDOVLJDINE AND
ZALCITABINE ON QUALITY OF LIFE
'estai Mircia A*, LersderissoLWR CFrschrI- 1, eI-K'I tDA, '1''UI lur i A(l 4,'1.to: tire
AIDS flinricalTIi ii CGr oup (AC TG "Hi:rvrr d Scisoslof Rutlic 1: ltb, I) ii s:0 FMesdiral
Schoolitoston IA: F' l otliti in toaRorhrNuatley, NJ'' Rift) t At5Inltr~io 1
Arlington VA: H*"bUii.sotf Washrrngton Sschool of FMcdrsic', Sraitile. VA
Objective: TirdsterimnoeIhe diriprelatect qtualitp ot ift'eeftts I(QI i) ntfsq ini i(SAQ),
a Pr otease inihibtolr,;ps ii rsrirbinaion awitt: idviu cut r(PV), indI /fV inst s citibine
(ddC).lcomrbine'd, scat reli5i d to ZDV/ddC rd::l:nuc:esidsetir pp
Methods: Two [rand:red ands ninrotyseen t IV inftectedI paient':,with ts leas tiourimott: at
Preisus ZDVther appysind (ADtcounts I et soon 50-10(1 ce1l is s::3wo:sre'enrled in:
AC] H Proto~col 229, wore ranrdrorr:ed I 'totser SAQ 8100 is: t ID,)ddC 0J5 rWig IIDor
bothr at ttese'agerntscosmofiner thbZ/VNP20)0 ip TIC)fots2: st' ksisitnd sr' i liialc'
for ansalysis. Assessmenrtsa o: eceived, an: lion:1.mad pyalicsl ihieaith,,to: I/soriialirole
fuinrtioning arid symptomi srsos sore 181tioeI it vssos'f 0 isnd120. C)4 1:orntsiind
adver'e event s /re rrnalpzed is the pr imary peficacy or:id saretp isu res
Results: Paiiets t:reatcd ewits thei'ple1)1'SAQ/ddst:/DtV r egimenrihfd a sigrn:fisanil) great:':
iriovemerit in I 04 I rollscounria unsider tthe cirve as c sir iied Ino'aAf/f)V (p 02)
irnd ddC'/Z[DV t(is'.00 1).irs sirnitisicr tdiltersecsisthre raits' ssf:1::ini r i i t iis
adve:rso ceaction,; wer on a:s wso-hrsdsert fiy>pa'v tie:tsi(86.f%) ctrompilete 101
data t week 20. An asnI':'oitvsianciie of raiws scorecarf e i op' ii: i corn iso rabfctional thealthctharnpes (scale rangi'0Oto 100) for SAQ/DV (-1P /:rsd SAQ/dclC/ZDV (1.6)
as cormpared to,?DV/ddf -8. 1), p '=.05,taut norithefItic'et:::duoenons.55AnisaIpsis rof the
'inked scores also strewed a trend in tavrr of tisple rrmnsat1:iiothorap op t r Ic' pereved
health, pspchological red war lsoriirtfunfiresn:co mpissite a c iis rrie o crralI somnsioes
(p =O0). No 'rgnifirant ireatmeneeldiferenre s efound oird:sirrt cidistress.
Conclusions: The' etficarcp benictssof tiplo sr hbis ai: si:einotiafflected by ceitic': idditive
or spriergistrc side-ettects of triple comsb isation isntiviral tic':apspwischrtsirpl 1itariot qu laty
of life. On tthe contrarptrove dita siapportI 'lbs tr errisc tithe iisad11:1ifs i ' ints:: to
Z[DV/ddC' comriatithe raii':ilP i poae rt.cass: el risriQOs
W.R.I erider kinrp Pt:as 2 Techno lopies, Inc. 2(0 W:1::Sireeii,5PWc'ir' Jr liy,11: tP
Tel. [phone]: Fax. [phone].
Tu.B.543
CHANGES IN QUALITY OF LIFE (QOL) INDICES BY TREATMENT GROUP FOR
DELTA TRIAL PARTICIPANTS BEGINNING HIV THERAPY
Hooker MalicrainsNether:rp A,Nonne A5,tisiko: At"-,iar esA' ^,Caitolais) s! so
*-i a tsr ie -L. i. rP\A t IV P1\ i sir 1_T__.i': I r. _ H b i iCr I 0 c i //u is is.vsor -iro

change is scre isobasetinsre ma' zero or clsose to Li'ero. iesr: oss igspoi or of any
significant henfc ii (-rIvse etfect by tiete rntdgroupthuv far VA scrlse A rave: 8 sweeks
the mirumsirhccii;e 's dalsoycore wais a drop of 0.99 (IQR -8. I to 4.36) for ALT A-dcl,
zero far A/I f ire scsiroaALT a ddC.
Conclusion: Pa: s sr's It hiss~m oal scares Issw no c ideusre atfsi lieu esccss 1 orveer Ireat1
msenot groups. Lonps imeussr isd coparisons and alternaive scales will Is piresntesl
N IlookerFIRc HIV hIC'nc ii Trials: Centre, Martlinen Mi:ket Centre (off apper St)
Lonodon WC I E AHTel 0171 380 9991 1tFixO0171 380 99/2/3
Tu.C.120
UPDATE ON EUROPEAN UNION (EU) MULTICENTER STUDY OF OCCUPATIONAL
EXPOSURE TO HIV IN HEALTH CARE WORKERS
Do Andres Rafirltrerez I Ccsntrer as GH the PErapean CallaifciivyrSstdyisruspir
Accidental Expsur to 111/ P NBC R. Instituto do Salsid Carlos III. 28220 1 Ilo idils 5di
(Matdrid), Spaiso
Objectives: t1 s Is aic'- 111thes'rislkrftI IV tronsis snfol 5r515 ifs sr~tirs itxfoisurev t
health carer'waore I-h(i/s) us: Furoape, nalize thse c ncrre'tsnce eltetd s ntes cre epa
sstres, mcIdson sir pisr'rention soldcersated in the stiffs':eout cocrotries.
Methods: A mulctticente':p prpctive stuidy isi occuion1:01lIexposo:e to F tie int1. =2,.s
begunoin 1991, irn:nced feyite Eli.Fist:ry requarremoents inclisdecspe cifcextpsssic'tisrI - r zr
HIV-caotaminaritess:urcrnegitive baiseline senralapyirnd fc Ia r sp testingat1.5. 3 6anist I2
msonths. Prevenonissis c' cus nside ippliod in the differentt rants ore r'riesented.
Results:Thrropgh Jusre 199526cdocurmuent definte acriupaionaly acquiredt fitn fctous
cases siaso seen repor terIds innuape (France- 1JOSpan=-41 JR)K4, saly=-3,Be p iris=2,
Germsaiy -2,mud Sweasrc:lansc= I) cant of 79 mrs the was d Thse 005rill In in,isIsiO: rats
Coend is)/3/91Ious soc utaneaus (0.23%) troslI /I1206 foa s cocltsne a 5 cxp Dir mc
(0.08 %0).F ailue f % rf-;eO ire prophylaxi swith ziud nroccurred in 4 cse i " n
= 10). Irsaisamrpule' of 't477casres (27.3% xunoscutneouslasnrd 7 I. I56 per ciiiarieous ex)(
sciresrmostlyp ro sstusksp InrnmSpain (269),HK( I140), Crrece (40) rnd LDernusark (281
mast either knewv (53.lxI~0 or suspectsct (I 0.7~0x) thse IV statu ca t hemouarsie pahrien.Isn
Europe, here s it least I nosn dCVV rise of HIVPtInss:ioun at rams' whale cus::
people livings itllsAIDtS
Conclusions: t hurtransrn S~on mole irs tis stiudyips coisnItenrt wills sluos' fous inmu otheu
lirge prospecsive studriesiI indicates a greater- iik for a tserctcneo us (pasticul:rly
ceedleshuck)thtameftr naenmnccuaneaus expsuren. Fhere s nra way for mccie icco
roendatia on te xpuareo prophylaxis ssiths zudovurhure. (tO site applicatisor of pro erumio
palicues needs lt e betesr ncccn:aled, nclunding tiraining needrvwifhldCi' feedbasrk active
pa:rticipations ic sesinarid imptlementation.IFnrthoer- investigation us needed an pmatiul
waps to reduce r redlestucks inuriensrinlding the develapentoof newtsmoodicail devices nsd
sifer techniques. Reporting systems to docsumentol ccrupatiornalexpaosure shsoculdhr eansd
ed 50 thaitmr reRio: c'risk factors, suschsas lailuresme 'he our silo proeveti:osepolcius cur
bse identified. Focusoarmis mrattr- n voslurleers of theronrsstatutor y sectnor usri5snomiy
members when rsangcupis ilso a ineed to pip attention.
R De Asnds, CI 18CRIn:titutmalde Salud Caohs III, 28220 N r odator 5 f1flisdl Spin.i
Telepharne: (1)16-"882115 Faix- (I) 6388206
Tu.C.121
DEVELOPMENT OF A NEW NATIONAL SURVEILLANCE SYSTEM FOR
OCCUPATIONAL SEROCONVERSIONS TO HIV IN CANADA
Robullard Pir're". Royrp'F (opal M M o ~ntreal Diroction of Publu:iIc'sealh,1 1 5C 1
Hnivenrsit, School oft Occuptiuonal IHealth
Objectives:Toaimprtanve Isospitllparteicipatiosno theI oInadoiansunryeJlirce syrtem s:or cupatioally icquired Htdlifectono and to evpanrdthe system n to oilhen blohodtb1rnei
pathogensrapilolt prct wsas hold mcnI14 ocrute care hrrspitlIs of a Cu:adiii: p 110inct
doesclop anelist in mntzr tod srvellancivsy stel ous a acupatrss:nil eaposures 5 5b1oodis)c]
body fluids (88km sirtn sensconsersians to H-IVIHIBV arid IIPCV.
Methods: A use r-finrlyp comspueized programs was developed with LPIINFC, sohtware
usung modified veon onf bPiNet questionnaires an BBF exposures and a:0e pRoa inr
post-exposure follos'sup.Idospitals were recruited through a convenionce samsple this
included venmi-ruralssall c onmunity and large urtan hospitals. Dati Nose ccolected Liy
oniplopee healthi services (May 22 Ort. 21, 1995) and included type and car cutsstanc's sof
expasrrues, devices incaolrid ins exposures. infectious status of saure patient, ob title of
heraltth core warkrsi(I h~swork unit ran ripysits of soposor s sandItostIres'l55 I
HCWs exposed to infected psatients.
Results: S5I7 BBF expasursnes (449 taos rnsanreous, 68 miscocutaneosus) vieesopor le Iduanussu
the 6nmoanth-study. Of thieve 'tO(7.7%0) wera'Ir t oreted sauccc paiernts:IV 21 139;';)
FICV 14 (2.7vv), 1lBV/9(I7l including 3 (0.6%) lICiNs exposed to patinrts no-inected
with HIV ind1 138 /50 %a of FHIV expoisures occursred to nunse's, I5%vtorus iients asd I0It%
to clinicil lob tehoisccess. PS% of DIV erpo sure wore' reedlestucks Isut only St1)0af thme
nseedless sad visiblelo'dhin sia:there even though all hr d Ieecnisect ourpaiet as iA iltrio sopr
seed~rle frono IVIon,' 0s' 27vv) mod rapping ((Ovv) cne the 27 ins t 'fr'snt rnia satfHI\V

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