Abstracts Vol. 1 [International Conference on AIDS (11th: 1996: Vancouver, Canada)]

Tu.B.185 - Tu.B.193

Tuesday, July 9, 1996

Tu.B. 185
"ANTI-HBc ALONE" IS A FREQUENT MARKER OF CHRONIC HBV HEPATITIS IN
HIVINFECTED PATIENTS
Hofer, Mtrkus, )cyjavi,,,,jJolryFHI.' Jro 18'L thy. H, and the SwisHIIV Cohort
Study Dvisor o Ifcis se'sosrrd 'ClioralerrunoroyUriversty Hospitar
Zic0, Sw tzer rrn3
Objective:)7oear jib eHA IVofted atierrs witr rati-HP 00 o'' astheonoy seoe ca
ma keyr' ofHBV heprtitisfo r e eor'ofva DNA ir hr oen srurr rrrrre irnd Ifrthe
tim o urrse ofther m i r rand lab ratrt y paramer ters
Methods: Betwern1089 rrdI1)"t, 68 oh 2) par ticprnts of hrZurich prut ohthe Swis
HIV CohortStouiy oHitavailable epatitisseorgyyproeorted wt8 postvo arti-H~c, bit
nega irti-hIP HB artiger irnd rot i-IC VThe068 ratorntswore retrspectivoly
o es~e or teir- lnca re ard/iLl,/i res.hroze rumorarrrples pprox.oeper
year oer tdowhrlerfohow p)wrre rot rooed rd oxairane hor HPV PPRHPV s PCR,
deo roploxe 3118 rr a tryer, rrti-l1, rrnti-l l a I y / M, red rrti-HCV
Results: The m00nrrollw 'p wr,30 manrhs rarye: 0 0)wrth arnoareryge oh3.3 oxarme
rened frozrr sorrrer paltietMeliarr HI ymphocyte oart it Laoelroewai3 1S/pt(ranry
10-010) Durrg te whlerfolo antrrrHP c rorr-ielr heorly positavr oogcy
result(wth prrsitnggtr vey r tienrl nryrrrI rt -HPr i67 (98.5%)patornts.Howoer,
proserceof lrarticle ar forrdlhy IPV PCR ri81820 )by HBV-sPCR i59
(86.8!,rrn3 hy Ico l er IHP' rotigeoon r5 22.1%)p trert The orrlHACVscreerr
rng yr'dedrovt tertvresIuts yuingrI tiar lyenerrtior 'sts: however retetinywth r 3rd
generrttio ettctedpostoerrti-I lV it baseli r i38(55.9% prratt, with 2rddi
tioralprtetsor: orvr trplary gth l w up.
57 patentslradI comraetercinlr rndI atrrlryflowaup.Of thaseh5 wrtl postooe
HBV PCR, 2 1.2 hir lov~Itd ALTfIor Cemortlswithoutary other raornrthrr
ehrori rvrri ralhpi satir:r C.ALT eloaiowessigyre requerntarongryptets
wth cocr rrr'rn rrr or ( a /94a8%Ito rrrirnorosr t osirve HBV cPCRoaut
negrtivororti HCV(8/22) t Ieyitory wislireserr ir 29.' tiprtor
Conclusions: "Anti B lonr"rr asoinr88.2% irir rerf1hr r ad rba blryiolectioes
HBV freyprtrtisririirrir e dIc-ieortIpatrts irs detectod bypi true HPV-c8CR ir orrem.
Ahter 00xclrsiono theretotoires rrdIof1courrent fII Vlepratts, 36.4%of prtornt wth
*rrti-~ H alrne" resenlt ihALTevtio frlr'-Cerths
DrMilCtOpavl,I a ofIfr or[o r ee, UrersityI opita,809 1ZurhSwitzerlrod
To1 ' 1 1 2,2fry332 2: ax 'III))5-4 9, r rr r oI err I r. icrzh c
Tu. B. 186
A CASE-CONTROL STUDY OF RISK FACTORS FOR CRYPTOCOCCOSIS IN
HIVINFECTED PERSONS
Hr iroC...B, Stephens HD-'r Baurrmrr V,Prt rIA+,P ltr ack ) rjaitwaryr' '
Scuhahrt A", Prinnor 18'. - 1 rri3demry JriversityAl rr t r rod the VWsterr
Cncrterr for PI~ hlr-relh a r Er rr 135/iS.
Objective:YTo et. rrr ro rirlerdentrt I Ifi tr Ifr rypt rcoss((-)aonrHIV+ persos
Methods: roasoro erireifiedtroig popultioh-baed rtivo survellroceornAtarta to)
Srr trnic SI) dir:'19)2)34./casewrasoleflt y irltioneoCryjloc r I err
Ir rem r orra r sorilr 1it rn 0HIV +-aperson wh rslde aroe of tho arvoeIreane
areFor F onicci or lr'idtfed13 crtrolrrmatchely CD4coerr rrd preary physirea.
Dtrreraysi sdca doa olgitrir r rsro 0
Results:VWeoor ol6158cae prtiortsAtata:i 8,1 ird15. 71rrd 425 onto-a pterrts
MastCCyratorts wererrol (931% rrraflh[ICD (unsi 00' 89). Hr err terrrayroroldetedemltleroiskfatrrr-, ncudig l cC rr orinectinruIrryure,oryrroette seokiny
ardsve rrr'rrvironrrer'r exosuer,rraprorec'vs fctrs ruihrarprevioue nrrrvrrrr
thertly arIprophyci rodicrtiorserrn ltiritotoriy rrconr oygfr CD4couats,
CC pietslwer irgnoriirlyemore lkeyCo. h0vo Leernrin wireouse wthirtheyirei'drn t oy d raitf rro1 (O1 )1 2,, b hC orfdene oIotervrl ( I).26-6.76] or have a history
Ifsxa -our ntacI withlarrirectin r triser(CR 21023 5%CII.09-371).Persoesowho
received la r rzole vithrntem ittLi-Ieforrrenroet wore syrrhfirrtly loss lky te
develap 0 (irleirstoOR 0P3'195%"-l.C6-072)
Discussion:pirs isthe farrtel crr cotro tudy ofiskfctors for C rnHV + persn.Preiussuveanrcer' rerod hir res fOCO rrrrg raks. 'lefhdrygsay'ger
raprronl rareorelto')ddffererces rraytoe do' t o'vironmeetaiexposueo rod difheretia
ueelf rio etarophyroti etsrr.1 oir -ire slon ica radrtr, oer stedy f ord syrnifirteffi
cayIffa ro a' oelfrreio of',-(.Avoa'c I irrs where pig0n rdo ppinysrac0
omelrte (e..,w ir 'I re rrayialio rodue rkofrCI

rto irryrsiswore: lyephocytecounet'< 1So 19[L Cl.0 b ematcrt'.0 p=.04),P2M
>29eyg1 p=0.301 ),NP"> h no/mwIp<0. 0 IroyregtieeP17/iL (p-0.8).I
Co model, 7omphpas ep=C.02)and h0/ P2M (=.00 ) "weae the'olyondepedent
prodictorsof proyressior. AIDS ostime ogressi0oerites it 9 yells n11IV-ifected diray
ad)icts with or asithoet lyopvee r rod higylPaM wore 92,tornd35%sp10ctOively
Conclusions: AIDS proyresioniamonrymyptomei HIVielectoo dirygadicts1was '44 rt
it yets.lyraphyroa and hyghoermlveor fP2M wre t basli00'ioyogcae mrkers
indepordently assoited with a yreater progreonrtI AIDS.CrGradsuport:hI' s93/16h
& 96/070

HM Mrro Infectroes Dioe Clont.)Hopital irri Vi
Prorio It+34+3+277i5586Fix: Iota-34+3+227z54

inoel 170, 836PBrce or Spair
aI eml r oortoee raues

Tu.B. 191
PREDICTORS OF TIME TO DEATH IN PATIENTS WITH AIDS
Martire Marerr A1,C o PH~, Peck CK*' '"Cooler- for- AIDS Research rod Edvrtio
(CARE),DCLCA Medical Cetrs ors'Aogeles, CA, CS/i,"Harlor= UCA Meialerror,
Tor raroo, CA, DSA
Objective: To deterrinre therti00s6ip 1betweren mdooftheorttocire syslemenory ' ln
vs hosptral)d'rrre toderth forpieter'PT s"ihAIDS and'odeterme teo'rre
froa AIDS defirray diryeoss(ADD) rod oseedAIDS defrarryilless es ADI) toIerthli
rr indyoent popalationof AIDS Pts
Methods: A retrospectivecharrt reveo i rgroup of HIV+- PPswOho'tereaIre ea0ltt
rare systemorfrapliospitrl iohLs Angylesoutrrinarorryear p0eri hr('6-89).
Selectorrciteirwere:() leygtuial r in rthe HIl n ohr tleast3rmoth,; 2) derll
1rnor to Jiaury 935 whileorder the ocare'of therHDV co, road I(3)ertl rtlriLuted t
the rrr hleaI Or ofAIDS. Subsequenly,2)'rS Iarts were oseered forronli.Subject
weoe srtfe odtgroupas: p 1 onry orheral th car yre i'e,theo 'faierrHIV
ciri (CLIN rod (2 eory via adaionto the osfiraoreaorieyeoo 1HOP P
Results: Hear rye rt derth oa 37.5 yr.There wire 88 ralres.38% wore whito rod the
remrrinodor were persors f olor The fhrst AIDS defining diayrss AD[)7foI- 6SoI PTs
wrs the dovelopmeert of r AIDS defininOill00s ADI),vh ie for toe remranrny 35~, the
(ADD) was aCCD4ll ol arlaf <200roes.PCP washr ost craeorADD (39.6~))
frheioentime frmADD72todeatf wa 21.53emonllsTherclaote frori ADI dry:os
to derth for- PTs with MAC wrs 7.92 aorths: CMV diseh687ramohs.arnd oraphomor
6.24mornrths. For- thac129t55%)CLIN PT,theleaorrtraelrom 001:t1 erace to derth
was 230rraonaths, while the 1ICC(450) H SP PFls0hid rrantourviva C 9 67amoth.
Conclusions: Sever alpredcsodIftet oo e ilatsr're ientifed irca3drngALDD72ADI 11a
a Jo f eotry tothe hearth crroeytor ChIN P1s lved 34eoth lngrye: o rato
thar HOSP PT.rCotrbutyfrctors tOhisoefrrrry betheoerier ontitionof Irrlrovirl an in raphylrotictheraip oirnCLIN P3s
MA. Mairtin, C.APRE. PBH 4 12 HS), UCLA Medichooeter; 0833 he Colte Are,
Io Arrtele CA, DSA 90095. Tol:(310)825-361 CiFx: (10206-331
Tu.B. 192
PROGRESSION OF HIV DISEASE IN A SEROINCIDENT COHORT:A STUDY OF
256 CASES IN BUENOS AIRES.
S sto AoicCahneP Surorre iM,.Lrttoer (JOchO le, ucrrr fl.PerK. -He potr
FoernardezPBuesAresAryertrina
Objective: To tudynoteral history of HIV dosaer on0licofoit ofsetoo ovor Icr
Methods: VWe 'trudy a cahrr of 256ratironts00 )wiOh Ceowrior estomaled datro e foronver-sr EDS wth arrear folIwaupof 14.5 moths (ro)[[72 wis alulatediasthe
wrapoi01 Letweeora lst HIV (-)rod first HIV (4 Paltentswith mre rtharo 30 iothsLoreswocr
HIV teotI wore eor adod.ap in-Mooer rre0h'd wis us0)1o redo AIDS rod death.
Results: Proyreon00to AIDS was seer or '5 p0:13PhP 13 tabe:cul oris(38,.Ko i ss
cown (KS,'5orytoco cosi l(CRY,S5CMV retrnitrs, 4 C IilI gel cn1111 CsO,2 dis
serinaruleHrpei' plart DhIS.2 progressrye a 01 l err oreli falarthy PML,2AIDS
dementiar eplex(ADC),2 atypicto ry liater isi MA ) dIof erho -o lao 7ryr
phomaa(NHL), 1 I presos s HIS) n rol raolpr] ioisCR72,11 4.II ps i ed.

YEAR Ph -PT78. 185 CRY CMV
I 2 6 2
2 5 2 1
3 2 2 2
4 2 1 1 2 2

)H11 PML ADC M/It NHLIHHS (Rd

RA. hajolCD3C~ DPMD lIS A- 13,60Clift onRa, AtlartIi CA 30333,.USA.
-1r1 4)010-31568 Eux: 44 16C31)4380err r - rfh5(a ddhd eriro),00
Tu. B. 190
NATURAL HISTORY OF HIV-INFECTION IN DRUG ADDICTS:A LONGITUDINAL
FOLLOW-UP OF 171 CASES DURING 10 YEARS.
Miro JoeM, Azoa' E,.Pcdr CJarciarFSerranrJLozaro L, Mr Is i (,elraX, GlC,
Cute) JM,Puolet~iuAM, SorianoF. Hospitllino rPovlrinilPBr elooi. Sparr.
Objective: oidecnrifytho01bioogicl mrrs p red itnrres'i0n00oAIDS ir ryraptc
ric IiIIVui' ritd dryg dil I
Methods: LngytrcdrIa8 y f!71ryraipl rr idruad13ts whoselHIVrrfetioewa
diagnedot i-86t7.O'aiats'res''aai,t asy oll d anallyuntl auary O.The fC

I
oin g ury t81rmrr a0ionr ca
eve lo rrf2rr I a' I
al Ii ' le oi o - c cur
P21 iaesie o L 1,-erari
3987 L7CDC riAIDS
tahlewore coma predI ly
evaleute indoeaor IctrIae(
Results: Moda10 1olltwat
dove _pod AIIDS, IC 27%

re tare rfredit bseie: RPC,V'2PC redlplatrlet olssereor
uin P12M,r e abc nNP,ltraor 10:rolisrator (TNE ard ol
e"sII-218, ar o dos ryantroreOhpronsp1 7 Pr17-AL ro
' )IV hl arti nrAIDS dryrnosiswi performwed accordirytI
prayre sr ratos wre etmated uairylifetarle rorlysis.CLfeIte logrrnktetoIACox propo1rtinlhazardode wiseued tr
dIr r f prygerro.
ofthe 171drug rdd itwiascouyer.ED>tysx patients(33%
= ied rod II(trua ddcts C%)wore lrayterri r I ptoyress

'C 2
MedrnItie t frst deiringdrseaewias rlnhs,:PCP,TP 19, KS24. C 27,CRY 2,
CMV '48. Mediantomtro IAIDS wa s 68, with areoetrmated it 80 rr.of50%for AILDS
to) 76%Iior survivil it 80 moths.
Conclusions: Majorty of HIV +I pt l ria10 free ol disese dol 17 theffrst. 6 yours fter
sera orverr o, tt 3.60 eveo p AIDS aro edu r rinay ohiperrod.PCP 10daTB were
therrost freuet and early 31crnod disores,L oth ireoiLe oproph>ai. Health cire
systerrmu111mrioverrlydetectioand treatmentlofIHIV patoien
Arici S tat r an 79 (I1 81) LeoAresAryortri aP1on00 Sir 3 81 828
Fax: SI 1 983-7;174
Tu.B. 193
EVALUATION OF VIROLOGIC PARAMETERS AS POTENTIAL PREDICTORS OF
ADVANCED DISEASE IN HIV-INFECTED CANADIAN CHILDREN
C. Mar shill', P. Coray,..Aller J.ForbesN. Cupote, S. PeadS. Mo. nP. C: Ib,
Cr I, [72. Moore J(CGlmwoa:, 1.8011 a ss,J].Tob, rho Cnodito PodatricAIDS Resear
Groupp. Pr itis8 1oaurila Coore for [xcellercein HIV/ AI[S, Varcouei, BPC 101anId
Objective: To eslauto urd crrelate v ir y I a:ame010s 0nHIV ofe red urnudianrorldrer.
Methods:Arnatio-wde studywasrcodicted1t001x 10ore oelaiosletweeolr n)il viral
lord, cell-1s0ocitld vitralodviralpherotype ardlZD7V resiarceour) urroyato urd ctoi
caltrkers f pediatric HIV diorsasproyresi on.HIV+ podiatricputt11were 10cruited

C

ICTNI r(aymiptomI a bor p at nslh >500 [At pLdurrrg8yer
ma tecd r ater'f proyr esion to AIDS or. -, 5, 7 iana 9 years were 2%
II% respectveylyrigniirt arc')cto:sof illmorrapid progresor to

offolo wap Tle eti
tO 10,22",.33> rod
oAIDS io the uarir
233