Abstracts Vol. 1 [International Conference on AIDS (11th: 1996: Vancouver, Canada)]

Mo.C.1676 - Mo.D.1684

Monday, July 8, 1996

Mo.C.1676
PREVALENCE OF HCV AND HTLV-I AMONG HIV-I-SEROPOSITIVE PATIENTS IN
MOSCOW REGION, RUSSIA
Bobkova M.&, Sankov M.', Padjulkov L&, Bobkov A. Ladnaya N.N.*, Buravtsova E.V**
1 he D.I. vminivsky Instit-te of Virology Moscow. Federal AIDS Centre, & The I.I.
M-lchnikov Institute for Va cines arid Sera, Moscow Russi.
Objective: To estimate the prevalence of HCV and HTLV- I among HIV- I seropositive indi
viduals in Moscowv pgion, Russia.
Methods: Ih- sierum samples derived frorn 86 patlents with the confirmed diagnosis HIV I
infe tion were tested for antibodies against HCV and H LV I by ELISA. Most individuals
stdied were infected via seuai route of trnsmsson In 1992 1995.
Results: In general, the prevlence of anti HCV among HIV infected persons was found to
be a reaas 19.5%. Moreover the prevalence of HCV in homosexual men was equal to
the occurene ofnt-HCV antibodies in heterosexuals (I 7.6% and 21.0%, respectively;
pO.001 I( None of the sera was found to be -ITLV I positive.
Conclusion: hese da Ii demonstrate high prevalence of HCV -infection among HIVIseropositive Individudls in Moscow refion.
M.R.Bobkova, 5 M.Kaizyonny Pereulok, Moscow, 103064 Russia Telephone, fax [phone]
Mo.C.1677
SPREADING OF HTLV-II AMONG IDUs IN SPAIN: EVIDENCE FOR PRISONS ACTING
AS SHOOTING GALLERIES
Soano V G.ut errez M, Esparza B, Dronda F Tuset C, Menrino F,Vallejo A, Ortiz de Lejarazu
R. Gonzalez-Lah oz.The H-lTLV Spanish Study Group. Coordination: CIC, Instituto Salud
Clarlos III, Madrld, Spin.
Background HTLV II has recently been associated with the genesis of some subacute neurologicali syndromes and, rarely with atypical T-lymphoid malignancies.The virus is endemic in
some Amerindian and Afriran tribes, and among IDUs in North America and Europe. Given
that HTLVII is tranrsmitted by the same routes as other human retroviruses, the screening
of antiodies to H TLVII in blood donors has became a msatter of controversy,n some
courtr e par ticla y since more than i half of HTLV-reactive sera in the US seems to corresponrds to HTLV II instead of HTLVI.
Patients and methods: In Spain, a national serosurveillance is provided by the HTLVI/II
S)prnirs Studly rGmrol since 1990. Up to I1992 less than 20 cases of HTLV II infection had
been identlified. Subsequently the reported cases increased rapidly namely after testing samples Jrom IUs i njail from different Spanish cities. Up to January 1996, 147 individuals with
HTl LVII infection have been found in Spain. Herein, we describe their clinical, epidemiologial and viroloc altfeatures.
Results: Most of them (129/17; 88%) were male, nred all but seven were natives. Four were
Air ic rent, lhvng in Madrid and 3 were from other European countries. All but ive
sbesvre inlect rdr ug uvsers (IDUs); sexual transmission of HTLV-II and transfusion of
contar iritedI blood were nvolved in five and one individual, respectively I 26 (86.6%) of
the HfIV I IIDUs were co infected by HIV I. More tlhan half of IDUs were in prisons
when they were dignosed as H T LV Il. II nical manifestations potentially linked to HTLV-II
tweresent, althu i nca HllV coinfiedr IILDU developed a severe non-inflammatory
proxin/,iJ yop,ih ty.
Conclusion HFTI V II infec ron m ipresent in Spin, mainly among IDUs, with a growing ncden ice it uie tover ll prewvlencv of 2.0%. However in prisons the current prevalence
seer to [,(2 ~)und 1I 3
Dr J. 5on/ le,' thaoz. CIC, Insttuto de S ud Car los Il, C/ Sineslo Delgado 10, 28029 -Madrd, Spainr. Pone (31 -1 14 0807. Fax [phone].
Mo.C. 1678
IMPACT OF THE HIV EPIDEMIC ON MORTALITY FROM OPPORTUNISTIC
INFECTIONS (01) IN THE UNITED STATES
Sceik, Rc rd M. Karor J. War d J. Center s for Disease Control and Prevention. Atlanta, GA,
hntr cd StateObjective: To rne i u ti lhe effect of the HIV -pidemic on national rates of death from
sele( ted (-).
Methods: IJr rultiple cisc- dta fron death ccrtificrtces for I1970-1992, we calculated
ianni, iaeadj sted rates of death from vrious OI. We compared rates observed in 1992
with rate- ip rdicted in 1992 fr omr model of rtes fora 1970- 1980 or I 979- I 98 I as available. Increa es above riiducted rates were assumed attributable to HIV infection. We also
sesied reporting of HIV infect ion arnong deaths from OI.
Results: Cor p ison of observed ind predicted rates of death (per -million population)
from 0 1 n 1992:

Mo.C.1679
HEPATITIS B MARKERS INDICATE HIV RISK REDUCTION AMONG DRUG INJECTORS
Marmor Michael*, Alcabes P*, loffe D*, Krasinski K. M.Vogle-. Des J iinis D" 'New York
University School of Medicine, *'Beth Israel Mediil "eNto, York. NY
Objective: To investigate temporal trends in HI ckireductionsef.)rtmongrc rat iru necto
by analyzing trends in hepatitis B markers
Methods: Sera from the initial research visit, o'99 drugi nletor were teted t>y enzyme
immunoassay for antibodies to HBV core and, ace ar tger Subjects were selected by
stratified random sampling with strata defined by HIV set rpostv i red vs-r otirt
(1990 - 1995).
Results: HBcAb prevalence fell from 87.5% n 1990 to a2.'%,n I 1 HBsAb prevalence
remained essentially constant at 35%. Prevalence of ether HBV rker-nreased snfcn -
ly as year of injection initiation became more remot i., onc those beginning riec
tion in 1990 or later, 61.3% in the 1984-89 initiation cohort. /.0 iin the 1978 83 cohort
and 91.1% in the 1970-77 cohort. By multipic logistic riceresson ri i of rr ctiorr initiaion
and HIV seropositivity were strongly related to odds of h-ivi any HBV -arkei H IV
seropositivity conferred a 2.3-fold increase in adjusted odd, of HBV se opostivity; each sac
cessively later era of injection initiation sgrficantly reduced ttese dds (Iy -6 td 20
fold, respectively, compared to the 1970-77 antar or rohort aher noldrsy IllS trotu con
stant; duration of injlection career had no effect on odds of having ian HBV mar tker after
conitrolling the initiation-cohort effect. Results were unchanged by deletion of Iu ects
with HBsAb in the absence of HBcAb.
Conclusions: These results are consistent with reports that fIBV rnfectis cci occur rapidly
after initiation of drug injection.The results also sugest that equ ipment shirnt among new
initiates to injection has decreased over- trre, resultny ir liowr prns lences o fHBV mark
ers with successive initiation cohorts and a waning prevalence o-f hepatitis riarkers,r rng
newly contacted inlectors.
Michael Marmor, NYU Medical Center 341 E. 25th Street, New York, NY 10010 2598
Telephone: [phone] Fax: 212-263- I1095, email: mch,.el.mrrmoirhvccmail.med.nyu.edu
Mo.C.1680
HTLV 1/11I HETEROSEXUAL TRANSMISSION IN COUPLES WITH HIGH RISK OF HIV
INFECTION IN BUENOS AIRES.ARGENTINA.
Vazquez, Anibal O *, Santucho E **, Deluchi ', CanizA',stoR Benetuc '
*Laboratorio de Retrovirus, * Sala 17 Hosrpital Murz, Buenos Air s, Argent.
Objective:To study the heterosexual transmission of H T V I/I r, ouples in which or o
the partners was HIV (+) and IDU, in Buenos Aires Argentirn.
Methods: After an interview in wich we dicard iany kind of other r behavor, we select 87
couples All serum samples were tested for H[ELV antibodiets t> AP (Seroda, Fulribo) and
ELISA (HTLV, Organon,Teknika) as screening Ractives r samples werecorfirr(by IF(i
house). IFA rectives were tested by a modified Wester /ot i-fV / Bhut LDB) order
to distinguish between both types of HTLV
Results:
COUPLE I HIV IDU HTLV I COUPLE 2 HIV IDU HTLV I COUPLE 3 HIV IDU HTLV I
MAN + + + MAN - - - MAN + + +
WOMAN + WOMAN + + + WOMAN +
COUPLE 5 HIV IDU HTLV I COUPLE 5 HIV IDU HTLV I COUPLE 6 HIV IDU HTLV I
MAN + + + MAN + + + MAN + + +
WOMAN - - + WOMAN - - WOMAN + +
We detected 6 couples n which at least one of the p, rtr;rc i ItrLV 'i I/87 W
obtained no HTLV II reactive sample. In two cases we detected H T I'V I sexua trrrnrrssor.
in one of tiem exclusively HTLV I.
Conclusions: We can assure that the heterosexual transnmisrionr between prtersr n
heterosexuals couples with high risk behaviour to HIV were ris-m rkable. 0 despite o the
relatively low number of couples studied.
J.G.Deluchi, Rodriguez Pena I 385 3~C, 1021 Buenos A res. Arentcti
Telephone: [phone] FAX: [phone]
Mo.D. 1684
PERSONAL DYNAMICS OF WOMEN WHO RISK UNPROTECTED SEX WITH HIV
INFECTED PARTNERS
PinelArletty. GENOS Internacional, Sao Paulo, Brazl
Objectives: To assess intrapersonal dynamics ilirt froc-itate unprote.'cd seul,/ractice,,,m ath +.i In............ I.... In.....,th II\//A ir c

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wtr stabUle partiner s knrown to be l iving w Hi cIV S
)tfe,,-re 'Methods: Forty-seven women who were infected witl HIV knorw lay Irby theirt, prt
nerts were interviewed twice using a semi s ctured r-1 t-ussr-lr hat f 0 e 1 it xa
'ved & and reproductive behavior and emotional expectations/Ink t.o thernr at tn VV nr who. yrf p~ecJi~t twere IV drug users or commercial sex workers were c vfdesot Irt ie- study,i vrci to In r e t Results: Patterns of coping that influernced women 's decisonto /unprotctwe c, -to
d obsc ed wit IV their partners were tentatively classified as follows: Destructive: wormen who rmanifnlested
100 96 their anger in aggression towards herself and/or other s:Syrubotc: womecn who itiblshed
g.4 99 A4 a relationship of total dependence with partner; Submissive women who resigned ther
j 9)4 86 selves to their partners wishes for fear of his reaction: Romantic women who ersthbisc-d
I /4 HI 4 4 unreahlistic and ingenuous expectations of love, where dy Ip ykir)vi' hid ael trust ra\)
16 94 A tation; Mystic: women who wished to give birt h to a child thinkrng that he/she would have
I 4 H i 8/ the magical powers to restore his/her parents health; Fa ist. wormen who beieved in pre
5. f85 6/ determination of life where control was on a divine being who could Iways change the
} /9 I9 end; Penitent: women who attributed the infection to a divine punrisrrtont: Gambler
women whose inadequate behavior was related to the pleasure of risk taking; Denial:
ates of death from several O. women who denied the seriousness of the situation or their role determrnirng the out
omparison of the last two come; Apathetic: women whose prolonged depression interfered in taking onstructive attdeaths from these OI are report- tudes; Victim: women who constantly cornplained but never too k any constrccctiv desion.
Conclusions: Not all women wish to protect themselves: r icst th'r partrer'ns reior.
anta, GA 30333, USA Telephone: The reasons include personal and soaal influences..cdc.gov A Pinel, Av. Paulista I 499 L1. 3 1, CEP 01311 -928 Sao P ulo. B.r z Tel5 1 2,,"t7
Fax: [phone]

Conclusions: The HIV epidemic has yreatly increased the r
Most deaths from these O are caused by HIV infection. C
co/inirs suggests that omost IIV infections responsible for
cd on death certfidcates.
RM Selik, DHAR CDC. Mail Stop E4/, 1600 Clfton Rd., Ath
104 69 4495. Fax: [phone] e,email: rms 'rcidhiv I.em

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