Abstracts Vol. 1 [International Conference on AIDS (11th: 1996: Vancouver, Canada)]

Track B: Clinical Science

Mo.B.1395 - Mo.C.1402

Mo.B. 1395
SELENIUM DEFICIENCY IN HIV INFECTED PATIENTS
Bircur leanrPili )p.er F CMia B, Cr I ri d OArius G. Beep-G raude r B Dr iver site do
P1I e< - U ( Fr e PotsFRANE
Objectives: Selenium delfcicy(SF ))hsDeoftenFreorted in HIV inlected patiernts rrd
re tile tt ~ yry il Fassessthe [Oer ecetfSD rid associated fators, eeaosured
I'' m cii i i leels -i V iected F terlt
Methods: )noF F r de 1 ana1 trele c [[IinfecteFF1itsrr27/ females, 85 itl0s, mea n
wr- 1rere erroled i tis tuy.Eighty two patieets were sym ptomatFe
ncun AIDS pii ns.Fory ivewee o moBisea e,,~~n,35troexl,!,7 itra
senor 1r, ir r l 6tranuionFr rrpert h et reoleniumnleveFs were determincod
aFtin aii t - 'r rt i tcclique (ort: relrge:.60-80 prrL) Prtienittoth sotum
cii iiFc i s n5 pg/1- o erit i 2 direotionaFehoeardiography
Results: Frt ity 21 paitsttad Paiiorminlrseleriunt levels (>79p~g I ), 66F(59.9%
irlitit c _ t rrlevels '0-l9pg/L), itd 20 (17.8%) SD.0Of these 20 patierts, 6 died durig flFo Ft. Ninaof theI4uvittvs hard it echocriorarphry end 2 showed a loft venticiuFar
dysfuntion.1 i tatoniate t totSDttowev erghloss OR=7.295 Cl:.F5198.0), intra
venou I Ito us c)OR 4.4l)5(,FI.F2'.), itr f l (ORFF4.0:95%iCl: 1.2-1.0) Di
cli'r~,ia -u i ire ' 1FF= SD0;15 FlO.4189.1),toxoplrsmosrs (DR=11;95% Cl: 1.4 -'t 0), F'ntilbeoct 1nritl (ODR -F5; 9f).2-1714, ard ittree f 2 irtogobs
Fi)'l I t,R )1, 5% I: 7 18F
Conclusions: l taeprel imifindingcsrsuggest thit SL isIrequiert ir HIV patients. SD
IFx~r tiltFrherretdtoF o r prosirelnto pecific iniacharcteistisof HIlV dse~rc ~ pri~l fr s''7,at trs ndt v Flatnos

nutrition, in previous studies, rehich increased 70- 100% as ftt): (3) LBMNcem be grened, with
little recreate in fat whet the gai' is poetarreous; (4)HIV-positive owmer n maytart with
higher ret red fat, red chtarge tote slorely rt orast early in the disoerse; (5) Testoster one i
extrenmely vrriablo in men, perhrps socondary to chrnges inret. Thus, AI[)S is chirt ercod
fry strikeng termporaIl hdtrogeneity for, nutritiornal aed Itoatmerit iF t
Rebec rh IdoF, Dept of Muttit intl Sciences, 119 Morgan arl, FUnivesotyp 1Fraliori,
IerkeleyCA )4720-3 101. Tel 4l5-176-3669, FAX SF0 642-0535;
emima.nrich Uaeatur eber keloy.edu
IMo.C. 1400
DIGITAL OPTICAL DATA BASE AND ANALYSIS OF WESTERN BLOTS FOR HIV I
FOR THE PROVINCE OF SASKATCHEWAN, CANADA
Sheirr Bar lur do*m, Alfonso jurrde#*, Greg Hor seman"0. #Dep rtment of Medicine
RUFH, Saskrtoon, Sarskatcherean, *AIDS Prograrm, College of Medicine, U of 5, 5rskaton,
Saskatcherean, FCanada, i)'Saskatcherean Health Lashotrtor y and Diserse Contri
Services BraInch
lssue:The toarsive storarge red rnrlysis of~lesteir Blot )VVB) diaignorsis of IfIV irfeclion Itoe0
considfer ante diffculties as birds fade toith tree anldcomplex muoltiple banoing partterns occuii.
Objectives: 1. Creaing r permariernt Digitralnmage Dati Base for alIls/B ftrti
Sasklatcewaeer, 5since 197.
Materials and Methods: 1, 139 diagnostics tests tooteecerrired out by Bier id reel F)pot
diagnostic kits froct 199/ to Jamuatry 1992, and Srom Feb rar y, 1992 to the pieeon'. WB
-tip reer e errnred and stored by comnputer in rn optical SCSI per ipheral F.2 GB disk.
Softwreefor rntern~alizatiott, processtry, ard irnlysis tots Adobe Photosl op 3.0 RFLP 2,01
PAUP PHYI 1F CL USTAL red SPSS respectivy
Results: A digitl datbase has ben successfully comrpleted. FolowirngFiAtP iter i, 50%t
I166 cases) of set opesitives grouped at the gp I160, gp I120, p65, p55, p51, p4 F, p32, p24, red
a 98 recognition clusterI12% (10 erses) grouped in the ff 160, gp 120, p65, p5. 1, 4, p32,
and p I8B Four other groups of ten cases reer e also presenf.it rddrtr iin,'3 other breding
riatterns, rangirgyffonm03% to 2.9% of the populatron wre erontified. A yraphic representaroe tots obt treed by Phylip and CLUSTAL methods.
Conclusion: 0Our results tmry represent the spectirurerof reatitvity of the North American
2pidetoteTh s techrology llores fto r ssve WBstorage ted atelysi.0o ur- knoreledge,
this is the first tenor t of ar compolete Drgital Analysis ohfyB lotra defrned geogirophicrl
regior, ir Carnada red abroad.

1)r JF I I ',,ii ~

-Nout to Irtern(ci Mridie lrloeticuses C-fDPoitters, BP577

Mo.B. 1396
THE METABOLIC STATUS OF ASYMPTOMATIC HIV-SEROPOSITIVE WOMEN
51 rp. it r, P f~terrtryFIt elit hi', "Gizzird B. Depart ments IfdIV/GULM
an it I I I' (t- tiea rnirtstmtinstiei F l ill!
Background:Fr cr c ireotdlit onthceleet oI FIV orneretboismrrin asyeptorrrtie DIVft re~ivc v rile cue nI cx ilerene c' tin Itdy 11om0oitorhe 1i-mnlsttus ard
i(ld(.hmr rut ayhave iifItretometaic risp-ise tote irrsannttonal
and t1' r pc-t,t Itcitmaydiffer i r i tthele rx olho lV-ser positive subect.
Patients and methods. Fr t t ymtot ii eIV7 r Iersit ye torenor rere toatched toith tee
'rir~t,;it tome co i f trt F ort ii iroupt Ecuionr rerirreere ri ADS drrgros
Ar-itIF tir itr'F -n nil bdr reit' i at reir,Dirrilc orfever (vet

IS,

Sherry Brjit de, AIDS Pr ogram FDept. of Mir iobiology Rm. A235, H. Sc. Bldg
iiggins Rd., Saska toor SK S7N 5F5 [phone] (306) 966-131 1 fax

oh S. 107

Results: f'
nV )it P 1 1it
Fitx

iti It
I 'let

sti ''totr eC' i,it ) Fh a Fyllcoxitetitfir
di rts or F i itrl All ibt i-irid rsitsroent ofter
'Fit t ridbody coposliti(ftlfreerimass[FfF'
in~u~ klttl ire 'it,AppI]I by durlenrergy xray
CDF cubeF t tsrrne rom 18598 elsrnm3. C
eld for eht, we'Iigt ad ire' four reomen Fad no histbctof-I sae(CCI)furhdoahiyluk
IFClCt IVi 2, inet litycirard oneliryskit (CDC Is/F
INf Mkr ) Fir A1D1Dkg) REF (kcal/
FFM/dr
When 39.t3~I13 3 1 -F 8.91 6.' +./ 353141 0
8.9+3IF6 I3)'r76 6/r-1.7 35.1~3.4 0.
id iIr f 11 kt ii 1 yI tcitt 07itio

-o ysterri discerse Mo.C. I1401I
stirg enrer gy expends- SPACE-TIME ANALYSIS OF MORTALITY FROM AIDS IN DIFFERENT PROVINCES OF
1], per cci t ge ftt CANADA: I1982- 1992
y Ibsorptotri Ghiadirir Prviz',Thouoir (P -, Dube P***, Bedsor IP**". *Researcli Cer te, Dotel-Diecr
aces and conrols de Montreal, DeparItent of Muttriton Drivetrsity of Nontiroal, QC, Canada. 'DepDrtmoent
or y of sign~s or of Geography, Dniversity of Nore al, QC, Cinada. ** Departmentt of FUtbIatnDStudires
-pl thu r or a histr y of UQAM (Derver site dir Quebec arMneitreal), QC, Canada.
Objective: To deterenino AIDS-relrted mortality associated reith spaice arnd tome (sersons).
Methods: Daitt on tottality (roto AIDS, from pirevinces of British ColumrbiaI (BC), Ontario
fit ox CH 00 ird Quebec front 1982 to 1992 reere analysed (1.965 cases: 1,701 totes and 26-F feearles)
NortIality rates reore calculaited based on populatior census of 199 F The o iritosreereo
05~0.02 0.1 +0.02 comrpared wuthmto alty irn t'e oeall Canadirr populationc for the stoe perrId oftire.
06~0.02 C. 1-004 Results: It tots found that the mDortility rate froto AIDS tots highest m~org emale itt BC,
folloreed by Oratario and Quebec. Fhe rate for fetiDa:es tots ighest ir Quebec. Orico toas
the second i rank folloreed by BC. Cotobirred araly-sis shovwed highrer trtatity ratot for
mnor DIV etopo ltive males aged 30-51 years, rehile the rate rea highest for ferrates in the 20-51 year go group.
In respect to the effect of seasons or mortarlity ftromD AIDS, the highesFtIrIto occur red i
(fthe asyreptormatic sprung rehile renter shoreed the lorest rate for- both sexes.
Conclusion: Mortality from AlIS s highest imong roales it BC, reile Quebec hais the
8000. errr i. highest rttality rite among femalesThese rates ire very hugh inriorgtDanrd lore int renter.
Flhe r'tltiito th e prosslelo'associatror of geograp1h iavaritions air IesonOrlrIeffects
on mtlDiyfro6mDDAIDS inth11eFstdy togiors.
Parviz GIDadurrae, Ph.D. Reserch Center, [piderorology Resorch FUrt, Dito-Diee of
ALn ANI MTA Montreal, 3850 St Drbin, Montreal (Quobec) D2W ITB

ft,Iv,% tt' I i i FIcxt 1 D I t r it)PE11
to Dit I end ' It
ConclusioaNut rd iecr yNJr-u I t
I IV sit Ft hr l t

copoition bettor

\, ) 111!s to neF -;
eD ~ i1(f lllS~

Iu ci ForIre. F) hitIlmtRotiFdtIoFedor Te 0191 716:E

Mo.B. 1397
SPONTANEOUS CHANGES IN BODY COMPOSITION, HORMON

IIo lilbt- I t'rewfrd A e lrteur MR. (University of Criforna at Srn Franireo,CA,
itd 1 (Fr r 'r I Calfr1iaI iFBerkelr'y, CA, USA.
Thr nt r Ir itra us icri - I urnrmetaboicptarieters rershollreedir59DHIV-infected
iile lt-F rot. 1Fewret).Bodytweght rt,bodyecrrpoition(learhbodytrss [IBM]
Mi ift) Iyr ti cunr too try isrt pi meti y (DEXA) ird CD1 count wore measured seni
tFll eerr, 2 weeiF ticnriolloreuprwa' 13.3 86rronth (menoa + SD.) (range 2536
i~tt a n rl ut-uuS-tntIntosterore,ID-,IFSI,echolesteFotrugycerudo - ird stable isotope
kintc ti - I I it (. p..u'e ) weueo to'asureod in subsets. At hasoFire, t = 69.0~ 10kg,
bod nI~ t -itoe (BMI) 27.1+2./1, usualret =91 ~8, %Ift(DFXA) = 6.5+6.3,
I 11BF r12 ~1.I ~F -cD 19718,ftge =32 I~yi Durng lollore-up, 99% 1fmen hard ore
ormoe Ii d" f->"g reF el ii'0' (tota 1 l)5 re eores t gfir, 5episodo' loss). Averige'
tot is owl&to oprmisrug or ins n.8gBhM atO I Ih/ry tt(53% tat);
avI t i t ret Ie' o etas 3. 9 -- ruwthl.8.91<g LBM, 1.9~+1.8kg fait (52% fit).
By DI >A -0 poF eIt FMtdGait toot' or vod (+3.0+ I.0kg LBM, -0.8~ 3.01g fmt) vs 37
ru r' II NILB I (3. 226kv7LBNM a-+J9g fit).Fr roenrhaselnet= 79~16kg,
II )11_1-6,rus re t F 14 6: lit =31+9,1CD1 =235+ 157, rge 42+8yr. fewer
eIoe, Fr' wtFret LBM ith-gewere obc-uvdclovetrI uoterufollowup (6rD rths),For
riot nt-r to Ichangeduiegobsertinrod[tos -21kg-vt (3%ret)with.2kgFLBM;
fo woen to r-u Fc rt, 2kg FBM Setumiestctoslt ee wtoremarkahly varribe itDeno
su iol vrage' chaInre (10,olte vIe) 61-:1108 0g/dl or squenialales(n22
rutg gi' Fl 8267 /dl)(ipoeei in contirstwas highly rpoptdeuible over 6-12 weeks
fa w pIll 18 1)
Conclusions: I) LUpsturd Iownit Dwrt nI LBM rue vetrycoromon even in tsns rce of net
cf<Ig i) th 'isII prl Itt ur, reth ret Iass episodos double the requency of episodo' rf ginF
() S C istunFgin rr forof- weight s rlouthf LBM, half frt (ir contrttDartficil

Mo.C. 1402
MIGRATION PATTERNS OF PERSONS WITH AIDS IN CANADA FROM TIME OF
INDEX AIDS DIAGNOSIS TO DEATH
Mg, Fdward, Whitehead J, DogFF5, Ricketts N, Lalornde P Fain-N., be T, Schaechter; MT
Dealth Statistics Division, Statistics Canada, Ottatwa, Ontario; Bureau of DIV/AIDS & STDs,
Dealth Canada, Ottawa, Ontario: BC Cere for Fxcellence' in DIV/AIDS, Van~couve, BC:
Objective: To characterize migration patterrnsir persroes with AIDS in Cmiiada rFrom the
time of AIDS index diagnosis to death using AIDS ease and death reportFr.
Methods: Hfealth Canada's AIDS Case Reporting Survyeilance System (ACRSS) up to
Septeme~hr 11914 wit linked to deaths in the Canaidian Mlortality Database (CMDB) at
Startisties Cinardr. ProcabliFrtue rinFrye was hared coa the folloreing ovetapioneg variaibles: inials, date of hbirth, date of doetla, birFteplice, geogiriphic Iocation, rid diagnosis of death The
prierary end poett exined tots the chinge in isual residence between AIDS diagnosis
and death. Rates of toiyraitoe wetro calculated stratifed by province or territory and comtounity cie of the area of residerce. Residences were classifed lay region: British Columhia
(BC,- Ortarito, Quebec, and the rest of Carnda.: arnd by commiety size (CSIZF orcerus
toetropolitan areas red census aggloereations of >500,000, 100,00(1-99,000 and
<100,000 people (the latter including stoallen- towns and r ur al tiers).
Results: A total of 5,755 AIDS caiset reported in ACRSS were lrnked to deaths in the
CMDB, ofwhich 1,586 (80%o) had rvailabe information on the provirce or ternitary at
AIDS diagross and 4,1 23 (72'%) hid data on the CSIZF at AIDS diagynosis (toisting were
mainly from Ontario). Of the 4,586 deaths where the region of diagnosis tort known, 1,605
(35%) were from Quebec, 1,416 (31 %) fram Ontario, 1,018 from BC (22"),(ard 517
(12) f romr the retofelCanadi. Only 119 (3.2'%) ofcaersehlar changed their province or
ternitotry of residence Ft deaith. BC tre the yreoatest ret yin rid thne rest of Canaida sire

124