Abstracts Vol. 1 [International Conference on AIDS (11th: 1996: Vancouver, Canada)]

M o.B. 1290 - M o.B. 1294

Monday. july 8. 1996

Conclusions: \/v'l eor r DO sIrio t boor pr evrrrsly repor ted inr[HIV rrhr
alhuhrrr o mulil iylrai HVaewl eoied a (()i H1V rssociaited rrye o ne is well swith -IV asoiated tyrrphorr is, [pr
to gorno ilteraitiosrad mrignr at tr rrrFor (natiers.Our p it etor wed n)r C
atont ho coure rf hiredisease hir been far iimore rygi e 'rye t1 )III N;rid
complete failur e toepond to id ii ibirro
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gececus I iii '\Ii i 2 Al1: -)) ul ti I '
fiter tth'(,,-'I Tt R1lfr In oIe t
orld lw n 1i svv or i ' Incfr d5'\7 F t ii I ) i,
forir it 0 r r(p" o it Q~1CfSln~fwn d y n ite iIII pu li ico ruinal )yI t ii t re I
hreted (ptt.A its aU I 9cr I'(cl tfo-, S i is If f< t i)l
ued iineonly oi t(4 )I',t, A so (n)It ottI (C~ tI~ ae c o i t is ct ((1 c ii al t o'n rlll
ar tlr do _ titer V/_r 0 t~ldfel cc~li ci ai,C Ii..1i

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Mo.B. 1290
HIV-ASSOCIATED THROMBOTIC DISEASE: PATHOGENIC ROLE OF
MICROVASCULAR ENDOTHELIAL CELL APOPTOSIS
Lauence, effre', Mitie i 0',Ste inor M"*,Starre F oioreIF ", JJfe F[.lDert IofN I eir
and "'Dept.of Surigor ytCiorell Driocrsity Mecficait Folege, New Yarki, NY bUSA
Objective: dontify riechiaiismore fJdir tf or icrorasr r i Jr Dir tdisorse tJ r iftic
thi omoec,O DFCic pID ii Di IiiJ P), oem ot iirer c yedrorerr (Ih-Ff ). e nd ci.rid i iia d
cec-ebrooasr cciidisorders c (,f(or witJ elevatseJ frirurnryireIHIV r rIii
MlethodsPlireaiiidIimite irtissesapesrNecoDtaie r o rnirilIIV Ie- iI l p cr1
wth TTPIIJIJS. ird fr omI IV- It+ Jhdreiiwwthiunexplared crdicfrrptiiitryyfi idol l it
cotl (E(-. ultureo wore estfiefid fir r i roce tin e of iHIV-thurerr crnrriousor
cvirebrali, doemalfhelDicrrrd Dciiioar y tis00urrnd roerraryevels EhoiJrr ie for iIopto
ors inductior in vitro wae oyJht by: rifhtscatter;DNA Jistogramsi sothficiunit ri e cf te
pre-G I A0 peak:; e idire cii rye reefDAPI staninry; rid err s e'ie, olectr ipfa ccii hof o
MW DNA Diet JNA stiineg ocr rood octf tisries hExpresseioofFasiIt DFlu <rJI Ftrii d,(rembD raroe piruterino isoociatoeI withiapopDoDiD s, oar ncel y 1 ypiPh if
Results: TThPrefdillS plasmeras, refd5 arne plasmirrafromerr I0carrd icpaieortI, r irc
apoptosi isi rer ci asua r bDiii ot rgei esyel00 1pi cci y F. Apoptoi iwasciniked Ioirirpi oy
laterofFahrtierited to icr rears ear F,rraciwrs indelperndent Iof F ralph.Ill oarsextor
sroe ir e LbfomJ r OD li, hraire in]dkIdrevy. but rIDsout ie hoer arid tirey PbID ii rile ii iareas
affected by1TVP hIUS in vitro.tier trier eifni-Fs arefifes, und t ertearoe ifi IIii iii ii iiir
carboexylic rcid (AlA, 0. I eM). 5Juppiesserf [Di see i medoJ itdoI ptoss.Funr I tt in i vo cr
relafes with, ti0000eii0areuder way
Conclusions: Firrov su~r ECii apop i ltosD ry er s of ID iff icrDioIcyic i~imotace inIihrer
botc disevi assi dafediwithr IIIV peritigfy rition if icidris fir paettoIgy tl
is consisfont with irthe Dlcko ift run lri ocrn i P I IIJS IlesioniinihIIlS+ and I INil
patriets. It cray 1obelcd by inti-his rcaentvifor biy i ifrihifrr rf cr I un pathwaso-ivIn
Pr ograicered cotlelcath,. 'uir IsiAFA, flirt hIieroeroouiDedI cliirelly.
JLaurene, M.D., beernellfUrivorsity Medicaii Foeleye'.41 'Fit[rt FhliS. Ness Y-)[, it
10021 USA telepone: 2 12 7th-2)881 eli 2 )-71601
Mo.B.1291
MULTICENTRIC CASTLEMAN'S DISEASE IN HIV INFECTION
A CLINICAL, PATHOLOGICAL AND MOLECULAR STUDY OF 20 PATIENTS
OkuonhoerdiecErc*, So ci or JVDerite M*,, Fin' ci II eecr, Ii',F ie viJ Ph F pr i ot'f
'Hp. Sf Loisr, Piaris:;i*Iop. Av cerie, Bohrgniy Frane.
Objective: Jo1o ec Joeicr aretrosecDOtior' 01dy.,reirsif or fri F rofiri iidisIase ofir U)1 in
HIV infetoe.
Patients: Thediaygnoeff"IFDOwns ofill ihdblymph D nudcel'pip ) )() IIIVrtintsl
All IDatientsohdlboornIIVifectellby 0exual0cDieaire At f ye i,I I1IV i fe' t rc. arte
terrafeiin 8 IDatorntsed KilD s' isarcomai(KS)sos re' r (, nIci."tern OSFD )11 reta
countf was 1S56(+99) xt06/I
Results: The patieento wore' referred wIrh a syrdiomre of Fe' vier n sp eocevy y0I%)r
periphel y iyph adeoaitt y (90)r rep foregvyly (70%, sever e weighet lss00(=71,cvpicrte
ry symoms e(65~"arnd edoe e5)Aeroir wiaerroesrice rid 7 (3%) ateon:s lireor tel
with parrteof Oia. Soierrm ccrccrsof irnftammDiDcc Iere pre0 cseent ccin otpati rent aIhri esol
oh FRP (90%), plOy I iD rIIIypc'cii cr ryl buI c1err cc 89 ) cud hypD D llirriri i56%)
The hisolgyeal pattern er e ilymiph indes cchae i rcr roe II rity cliii 'o yed e rriii
centecsorurrounidedIby corcenrtic lIyrys'cof erraitlyrephoiesovascular fryice rp c is rid
1 yc re zvd vessels, red acrye' ' efoha r sccheeooF IDisiv rell i Ve00pretent sowereocassiie'd
as picsma cvii type MrD, rid 1I S inecresclriplasmric c'lliiixedr) '01'.
Icero a ifn f ernetypic y frtIc'ies n ft) ccclc ar iilcys e f IlyV(t )] c'rier ngr rmeatI
fri 10) dcere nsr Iicld r Doly( Diil 8 e'l piecess olid ae ithc'ste~inori hir cc (FV
corld be errocrotrated I cin I Inoi I herrcIlly (I MI' Ir vI)hV-1)JryRA rin iu
hybrdzrtion (VBV~s (n-13 I.InJrcfi tr~ t NIA o eu' c' ofthe KS aso c it ri pe'sirri
were rempiFied using PFPcRin 3 ut oI Iiass.
[Rveissore was obtarened with lw Jose iidJusirally singl110gent I chmothorapipn 16
patients. Drring yfellow-ip, [Jill devloaedin2 patiecntsreid KS re I. A fatalrOutce i
occ.ur ore n1 atccetcs irh i cedicn ire.ialI f cercfont
Conclusions: Molt cenri re F Dt 0i a' disearoe aroeiatorI wiJr IIV rehfetreoris i Jrsticet clea
00-pathologeyetty.DI ty isvery scmtar tohfMV)D oor ved icr oni HIV refetod paitc
except for tho high prevareoc ofatpulmor cy syrinDfec icnd for lre' stirongyer isoerritior
with KS. Scerle igert e orethoray sowirhviillisfire is eff'ct rielicrmry pr bang our vivai. If
a crelationship betweencc IIV crepliretion, Fhe pr esence oFflehe KS issocifted Fbi Dc'sicus ccci
ittensse evyreholIceulac Ihyper DI cor iin lymo id ergniriscs ecideeed ias apossJute b0ifoi hr
the so eclledl Crotiere c's disceroe, theray chouldl roe t ccerti caiie F t e irifec tionr(s)ind
the involved refivated mhen ids cclpu ioners.. Okoevl endlec, ImnueDo-erafoloy o, IJ~pit ii Srinet-Iouis, I Ave FC.Ve'iief firei75 010 caris.
Vanceetel 33(1)42499690; VFix: 4(1(424994f72.
Mo.B.0%292 0

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crse rcc's ox
rels o(r7=1)1 n
pneu o ices 'r)n
ranficcced fi she
Joe IowcruseeJr
notr AIM) ~
is (aye' HIV
cc _to
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2 (29)1 VItO
( 2,11 IV r)I
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MoB. 1293
THROMBOCYTOPENIA IN HIV INFECT[ED CHILDREN
Sinio D M r yl', Vaio 1 KI I r>lccswJ, ~ w iI1rn il1,FlhSkn, kyY D pt fP da! icIr1 i ifs Jr Jr 10(
Objective 10A VJun PIntle Clricr rrn i 1nIre 'Icrrn'cec'-)fInnrat11
nfce c hilrear n.
Methods:VTwo111101 Jots ieelf/r I co n,,ti AIMhave itoe't 'I ol ~
Twencty devr'eonedJ Inu 'rID ayh pei,: >c0 n ls n'cn Flu ln i
cd onerinfc tedfbych fd p cs. Ssrlet c'cn Jue l l daru eDla
7d-nnuI. St-ive cr5,, wereclaifiedii sB, I s -Ind
oboor vaini ccc ft ly
Results: Becaure 0Ithi' sofJIVhrdurunghumhe/ ea'r,,i c,
Io oserveofo dfhc'' r ef!_- I ciper Ihend stcc n1,I).
eenoed VII ind J1ic en I e.())2 Oein' 1 2 1. c,111,1",;
rule o = rr. )(), <1u -p llr. i ' u 1 I III, i f c u n 1 T ' 1
fth r p cc;e i hny s I c'th'e111 n o' I 'r) ii r., I,I( vil 1
chidrec roofhi cetlru F ont icr thchIn i ' i;tIncur,i
os h) Jul I F ei o e ecI 5 cn 0 r ulis ric sl n Iniihis Sy!c ria
desthsechoseyurelatefto I eding indflu ml oftpours In &Fechc
I sh o cd rn r ur n s' uii Fin i' r n OfIlvi n r n i!n e1 n 1 ic
tsp nitaeus 5c~ilorr i ( tdern'",c ' i Iri, 'vrd. tin, Iap I I
to ccmpine ftho prece ein ccr fe t r,> rl n Iccr c i' t(I' hr
cseofIVIFG, waelevart (F iserec nt, 1 tld.oiMer'0H6)i tr
jess nuffiusdfo is Isufilciftto afirm in, lterclll ip
Conclusion: Vhe a crgen curt of HIlV assoitch t rn 'uly (-fr
tie pcflrcpay eolgy i no s ell andeJ ond In. i l ud rn' o
seeii eiVIrln iin /un,F/ 'JI! nr
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Phinur'55-1 1 26 i')

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c ) II, en

Mo.B. 1294
OXIDATIVE STRESS AND THROMBIN GENERATION DURING HIV INFECTION
7rcettith., Rotdardnc''t H.,'hBr- IuIl,' Src sA. f, l <>i. I i I.''1 'In:IrI,1.'II
['[nil F.V, ''IIRLB (-S 1it rlic n,'tfn it 1le thr. '!' I 1 u ''
VJoOI.Divecoity Fof avia, f Ie
Objective: houdien itfr<s n one n I ge fun it iii Inr ''%d ou
rcimuodedociecy virus(iI iV eplic if i c irIdicn uI c i i cin Ilieupc Jr
Liocrcnd DflA fin in ionfolio)ed'Il.FOterscw d uc J,ut i I Iin ii ~ <v,
trin Iiare been Ishont on II Dte' Ii ccl in i l ~ nincu I (cI' i I,i n h
anourcclitie0 d Duld r hin I uilute' o i s I c u r ' i I fI V r cc c ritnn (,
up a study Icoddoit) ennhsine bydront i h.Ic 1~('Ju.1 trui'f' -. c
coaagult ieroncrnJtir on rnygIIV infeters.
Methods: We evauatsed noun i dir Joy le(fntV), a.s iIrendex oftI I ron'ififr'et i Jr
damage, enrytferoayte glint af one per exuda e ctiit y (OSlI Pc, 1teii r crllprc e agei/nt
against the hrluaact refer rFueradcas, pc fIhi eD J i n Fraed'I,(F I i ID
dier in 22 HIV patientse(I0t"t, 1I. colgedt+hI) c,5tIn III)r
2lD0x b6sLrland n20 utrsufeod htorth y 'nlo
Resuits.TJho index of laerucrida or 1Vt1)A (7.51.280h or cI1 vs 1 ' i n,1
meeen~SD) cod the refiox Idnrt rare eculoeFrSl-I F(26061_7.'9'0 D 1 0 cii 'I }.I Ulf
Hlb, p<0.00()ocere sigrifirtly irceased ie fleAIDPS putiec ts As a Inn ithrhn ccl 0 Ou
lien no conceened, areo F +2 (1.35~0.49 nMalL[vs 079+0.27 ol/I, p<0F00 us and1
dimere(1.07~0.05 pg/eeL vs 0.28~0.12 pg ccL pi00b ) weroecnr edinrAIDS paterts
MereoseeraIodcorelat inbetween SlIP" nellD inner r -.>,".05,r'.IsI.I)(I

105