Final Program and Oral Abstracts [International Conference on AIDS (8th: 1992: Amsterdam, Netherlands)]

TUESDAY, 21 JULY 1992 TuC 0572
TuC 0572 HEALTHY LONG-TERM POSITIVES: MEN INFECTED WITH HIV FOR MORE NOTES
THAN 10 YEARS WITH CD4 COUNTS > 500 CELLS. Buchbinder, Susan P..;
Katz, M.*; Hessol, N.'; O'Malley, P.'; Bamrnhart, J.*; Holmberg, S.t *AIDS Office,
San Francisco, CA; tCenters for Disease Control, Atlanta, GA, USA.
Obiectives: To determine the time from HIV seroconversion (SC) to the development of AIDS and death
in homosexual men in the San Francisco City Clinic Cohort (SFCCC) and to describe immunologic
parameters of a subsample of men infected over 10 years who remain healthy.
Methods: We identified 562 men with well-defined SC dates among 6704 men enrolled in the SFCCC
from 1978-80. We obtained clinical data and CD4 counts at biannual visits, and ascertained AIDS and
death from crossmatches with national AIDS and death registries. Using Kaplan-Meier (KM) techniques,
we determined time from SC to AIDS and death. We defined healthy long-term positives (HLPs) as men
HIV infected > 10 years without AIDS with CD4 counts > 500 cells. We evaluated change in CD4 count
over 3 years for HLPs with CD4 counts performed at the same laboratory from 1989-91.
Results: By 12.5 years, 69% of the men developed AIDS Prression to AIDS/Death
(95% CI 64-74%) and 65% died (95% CI 60-70%). Of 100
115 men with >10 years of infection and no AIDS, 39%
had CD4 counts > 500 in 1991. These HLPs had a me- 80 -dian change of only -11 CD4 cells/year for the 3 years 8AIDS
from 1989-91; 73% of these men had never taken AZT. 60
~60 -Conclusions: Although the cumulative proportion of men
developing AIDS continues to increase up to 14 years 40 -
after HIV infection, a minority of men have stable or in-, 'Death
creasing CD4 counts. This represents a subgroup of HIV 20 -
infected persons who may not develop disease. We are
currently investigating immunologic and genetic factors 0
which may be responsible for slowed or arrested HIV 0 2 4 6 8 10 12 14
disease progression. N=562 Years after HIV Seroconverslon
Buchbinder, Susan, AIDS Office, 25 Van Ness Avenue, Suite 500, San Francisco,
CA, 94102, USA. Telephone: [phone]; FAX: [phone].
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