The collection, which was received in two accessions, contains papers and photographs documenting Guthe's work at the University of Michigan, including the 1922 expedition to the Philippines and other expeditions and materials relating to his teaching and administrative activities. The collection is organized into eight series: Philippine Expedition Papers, University Files, Philippine Expediting Photographs, Journals, Writings, Clippings, Other, and Correspondence. The 1944 accession includes the series Philippine Expedition Papers, University Files, Philippine Expedition Photographs, and Correspondence. The 2006 addition includes the series Journals, Correspondence, Writings, Clippings, Other, and Photographs. .