This rectangular panel depicts four sacred figures rendered in dark hues with passages of vibrant red against a gold background. The upper edge of the gilded frame bears the prayer known as the "Hail Mary" ("Ave Maria Gratia Plena Domin[us tecum]").
The Virgin Mary and the infant Christ occupy the center of this panel, which once served as an altarpiece. She holds the child in her right arm and bends her head toward him with lowered eyes, while Christ looks out toward the viewer and raises his right hand in a gesture of blessing. Behind Mary's left shoulder appears St. Thomas Aquinas with a book in his left hand and a sun in the palm of his right. Over her other shoulder stands a bishop saint wearing a mitre with his gloved hands clasped in prayer.