John Scott, the first member of this branch of the Scott family to reside in North America, came to New York from Scotland in the early 18th century and commanded at Fort Hunter in the Mohawk Valley. His son, John Scott, married Marian Morin; their son, John Morin Scott (1730-1784), was a New York City lawyer, a founder of the New York Sons of Liberty, and state secretary for New York. He and his wife, Helena Rutgers, had a daughter, Mary Morin Scott (1753-1796), who married Revolutionary War surgeon Charles McKnight (1750-1791); and a son, Lewis Allaire Scott (1759-1798). Following John Morin Scott's death in 1796, Helena Scott married John Ray Myer (or Myers).
John Morin Scott, grandson of the first John Morin Scott, was born in New York City on October 25, 1789, the son of Lewis Allaire Scott and Juliana Sitgreaves. After his father's death, he moved to Philadelphia with his mother and sister. He graduated from the College of New Jersey (now Princeton University) around 1805 and became a lawyer in Philadelphia. During the War of 1812, he served in a cavalry regiment, and in 1815 he became a member of the Pennsylvania House of Representatives. After holding other local political offices, Scott became mayor of Philadelphia in 1841 and held the position for three years. He and his wife, Mary Emlen (1795-1881), married in 1817 and had 8 children: Sarah Emlen, Lewis Allaire, George Emlen, Maria Litchfield, Julia, Helen, John Morin, and Julianna. John Morin Scott died on April 3, 1858.