Thomas Bradford, Jr., a descendant of Philadelphia printer William Bradford (1663-1752), was born on September 11, 1781, and attended the University of Pennsylvania. He studied law with William Todd and was admitted to the bar in October 1802. He subsequently became a prestigious lawyer in the Philadelphia area. He and his wife, Elizabeth Loockerman (1779-1842) of Dover, Delaware, were married on May 8, 1805, and had five children: Vincent L. (b. 1808), Elizabeth L., Benjamin Rush, William, and Thomas Budd (1816-1871). Thomas Bradford, Jr., died on October 25, 1851. Vincent became a lawyer and married Juliet S. Ray. They lived in Niles, Michigan, and Vincent was elected to the State Senate in 1837, before returning to Philadelphia in the 1840s. Thomas Budd Bradford graduated from Williams College in 1833 and became a Presbyterian minister, moving temporarily to Michigan. In 1840, he returned to the Philadelphia area, where he presided over a congregation until moving to the Loockerman family estate in Dover, Delaware, in 1850. He had no children with his first wife, Henrietta Singer (d. 1851), and had four surviving children with his second wife, Lucinda Porter: Thomas Budd, Lucinda Hall, Robert, and William Hall. Elizabeth L. Bradford married Reverend William T. Dwight of Portland, Maine, and they had several children, including Henry E. Dwight.
Samuel Bradford, Jr. (1803-1885) worked with several Philadelphia-based railroad companies throughout the 19th century. He and his wife, Elizabeth Ann Wood of Newburyport, Massachusetts, had two surviving daughters: Elizabeth and Annie. His relationship to the Thomas Bradford family is unclear.