Samuel Brimblecom was born in Lynn, Massachusetts, on February 11, 1799, and received theology degrees from Harvard in 1817 (A.B.) and 1820 (A.M.). Following his ordination, Brimblecom led Unitarian congregations throughout Massachusetts and Maine and also assisted in establishing the Westbrook Seminary in Westbrook, Maine. During the later years of his life, he lived in Barre, Massachusetts, and he died in Haverhill on June 14, 1879. On October 22, 1822, he married Harriet Buttrick (1798-1878), with whom he had ten surviving children. The couple's eldest son, Samuel A. Brimblecom (b. November 2, 1823), joined the merchant marine and traveled to India and China on several voyages in the mid-1840s. Following his marine career, he moved to California with his wife, Sarah Holden, and became a merchant and lumberman. He died on April 10, 1897.