Sanford Mead was born December 20, 1803, in Fairfield, Connecticut. On February 25, 1833, he married Cynthia Husted (b. 1812), also of Connecticut, and they settled on a farm in Fairfield. They had five known children: Alexander (b. 1835), Hannah (b. 1837), Henry (1840-1862), Peter (1843-1845), and Mary (b. 1846). In 1861, Henry was mustered into service with Company I, 10th Connecticut Infantry. After fighting in the battles of Roanoke Island and Newbern, he died of typhoid fever in Newbern, North Carolina, on April 20, 1862.