Alexander Trimble (1726-1785) emigrated from Ireland to the United States in 1749. He and his wife, Sarah McClaughry, married in 1754 and had nine children: Isabella (b. 1755), John (b. 1757), George (b. 1760), William (b. 1763), Jane (b. 1765), Alexander (b. 1767), Elizabeth (b. 1770), Sarah (b. 1773), and Timothy (d. 1810). Isabella married Peter Hill; Jane married Andrew King; Elizabeth married Samuel Hunter; and Sarah married David Comfort.
Alexander Trimble and his wife, Agnes Burwell, had multiple children, including Chilion A. (1798-1862), George, Isabella, Adeline, Catherine, Elizabeth, and Mary. Isabella married Andrew N. Young of Montgomery, New York, and they had at least two daughters, Elizabeth and Adeline. Adeline married George Brown, Catherine married Stephen L. Lamson, Elizabeth married into the Murdock family, and Mary married into the Chandler family.
Chilion A. Trimble served as sheriff of Essex County, New York, from November 1843-November 1846. He married Frances Charlotte Stone (1818-1886), the daughter of Leonard Stone (1776-1826) and Betsy Elizabeth Leonard (1781-1848), on September 4, 1838. Their children included James K. (1839-1902), Sarah F., Elizabeth, Andrew Y., Agnes, Franklin S., Bell Y., Chilion, Edwin, Charlotte, and Carrie E. James K. Trimble and his wife, Agnes Chandler (1835-1914), had a daughter named Adeline.