The Holme account book is particularly heterogeneous in its construction. It includes accounts of goods sold and services rendered to Philadelphia families in the 1680s and 1690s. However, the accounts appear to have been kept by several different members of the family. These include records of the sale of shoes, gun powder, grain, cloth, nails, and many other goods. Interspersed throughout the accounts are pages of calculations, numerous medicinal receipts, and receipts for various food preparations (including a large number relating to wine), most of which appear to have been recorded in the 1740s, though some are earlier.
John Holme, Sr., also appears to have used the "account book" to copy the laws of Pennsylvania (copied ca.1685), and he or a later Holme recorded the wills of Capt. Thomas Holme (1695; William Penn's Surveyor General), and of one of the John Holmes, probably John Holme, Jr. Finally, a poem and two religious songs have been included, the former perhaps written by one of the Holmes. It is tempting to attribute the poem to John Holme, Sr., whose poetry is among the earliest recorded as having been written in the province (see Pennsylvania Magazine of History and Biography, vols. 3 and 20).
Medicinal receipts are indexed under the term "Receipts" while those for foods are indexed as "Cookery." Additional indexing (e.g. for type of food or medicine) is highly selective. Similarly, only the primary names are indexed for the accounts.